Yvonne L Latour, Kara M McNamara, Margaret M Allaman, Daniel P Barry, Thaddeus M Smith, Mohammad Asim, Kamery J Williams, Caroline V Hawkins, Justin Jacobse, Jeremy A Goettel, Alberto G Delgado, M Blanca Piazuelo, M Kay Washington, Alain P Gobert, Keith T Wilson
The intestinal immune response is crucial in maintaining a healthy gut, but the enhanced migration of macrophages in response to pathogens is a major contributor to disease pathogenesis. Integrins are ubiquitously expressed cellular receptors that are highly involved in immune cell adhesion to endothelial cells while in the circulation and help facilitate extravasation into tissues. Here we show that specific deletion of the Tln1 gene encoding the protein talin-1, an integrin-activating scaffold protein, from cells of the myeloid lineage using the Lyz2-cre driver mouse reduces epithelial damage, attenuates colitis, downregulates the expression of macrophage markers, decreases the number of differentiated colonic mucosal macrophages, and diminishes the presence of CD68-positive cells in the colonic mucosa of mice infected with the enteric pathogen Citrobacter rodentium...
December 15, 2023: Scientific Reports