Alisa A Nevskaya, Rosa Purgatorio, Tatiana N Borisova, Alexey V Varlamov, Lada V Anikina, Arina Yu Obydennik, Elena Yu Nevskaya, Mauro Niso, Nicola A Colabufo, Antonio Carrieri, Marco Catto, Modesto de Candia, Leonid G Voskressensky, Cosimo D Altomare
Previous studies have shown that some lamellarin-resembling annelated azaheterocyclic carbaldehydes and related imino adducts, sharing the 1-phenyl-5,6-dihydropyrrolo[2,1- a ]isoquinoline (1-Ph-DHPIQ) scaffold, are cytotoxic in some tumor cells and may reverse multidrug resistance (MDR) mediated by P-glycoprotein (P-gp). Herein, several novel substituted 1-Ph-DHPIQ derivatives were synthesized which carry carboxylate groups (COOH, COOEt), nitrile (CN) and Mannich bases (namely, morpholinomethyl derivatives) in the C2 position, as replacements of the already reported aldehyde group...
April 22, 2024: Pharmaceuticals