Magnetic nanoparticles

The current study developed an innovative design for the production of smart multifunctional core-double shell superparamagnetic nanoparticles (NPs) with a focus on the development of a pH-responsive drug delivery system tailored for the controlled release of Phenytoin, accompanied by real-time monitoring capabilities. In this regard, the ultra-small superparamagnetic iron oxide@silica NPs (IO@Si MNPs) were synthesized and then coated with a layer of gelatin containing Phenytoin as an antiepileptic drug. The precise saturation magnetization value for the resultant NPs was established at 26 emu g-1 ...

The re-bridging of the deficient nerve is the main problem to be solved after the functional impairment of the peripheral nerve. In this study, a directionally aligned polycaprolactone/triiron tetraoxide (PCL/Fe3 O4 ) fiber scaffolds were firstly prepared by electrospinning technique, and further then grafted with IKVAV peptide for regulating DRG growth and axon extension in peripheral nerve regeneration. The results showed that oriented aligned magnetic PCL/Fe3 O4 composite scaffolds were successfully prepared by electrospinning technique and possessed good mechanical properties and magnetic responsiveness...

Glioblastoma (GBM) is the most aggressive primary brain tumor with low survival rate. Currently, temozolomide (TMZ) is the first-line drug for GBM treatment of which efficacy is unfortunately hindered by short circulation time and drug resistance associated to hypoxia and redox tumor microenvironment. Herein, a dual-targeted and multi-responsive nanoplatform is developed by loading TMZ in hollow manganese dioxide nanoparticles functionalized by polydopamine and targeting ligands RAP12 for photothermal and receptor-mediated dual-targeted delivery, respectively...

HYPOTHESIS: Magnetic particles are widely used in many adsorption and removal processes. Among the many types of magnetic colloids, magnetic Janus particles offer significant possibilities for the effective removal of several components from aqueous solutions. Nevertheless, the synthesis of structures integrating different types of materials requires scalable fabrication processes to overcome the limitations of the available methodologies. Herein, we hypothesized a fabrication process for dual-surface functionalized magnetic Janus particles...

Anabolic steroids and β-agonists are commonly prohibited substances found in doping control studies; therefore, the determination of anabolic substances in biological samples is crucial. To analyze the anabolic compounds in urine, an adsorbent, polyethylene glycol (PEG)-grafted magnetic nanoparticle material (Fe3 O4 @SiO2 -PEG), with low toxicity and strong biocompatibility was prepared in this investigation. Compared to those of Fe3 O4 and Fe3 O4 @SiO2 , the grafted PEG chains (approximately 5.4 wt.%) on the magnetic nanoparticles improved the extraction efficiencies by factors of 3...

HYPOTHESIS: Multicore flower-like iron oxide nanoparticles (IONPs) are among the best candidates for magnetic hyperthermia applications against cancers. However, they are rarely investigated in physiological environments and their efficacy against cancer cells has been even less studied. The combination of magnetic hyperthermia, using multicore IONPs, with selected bioactive molecules should lead to an enhanced activity against cancer cells. EXPERIMENTS: Multicore IONPs were synthesized by a seeded-growth thermal decomposition approach...

Maghemite nanoparticles functionalised with Co(II) coordination complexes at their surface show a significant increase of their magnetic anisotropy, leading to a doubling of the blocking temperature and a sixfold increase of the coercive field. Magnetometric studies suggest an enhancement that is not related to surface disordering, and point to a molecular effect involving magnetic exchange interactions mediated by the oxygen atoms at the interface as its source. Field- and temperature-dependent X-ray absorption spectroscopy (XAS) and X-ray magnetic circular dichroism (XMCD) studies show that the magnetic anisotropy enhancement is not limited to surface atoms and involves the core of the nanoparticle...

A major contributing cause to breast cancer related death is metastasis. Moreover, breast cancer metastasis often shows little symptoms until a large area of the organs is occupied by metastatic cancer cells. Breast cancer multimodal imaging is attractive since it integrates advantages from several modalities, enabling more accurate cancer detection. Glycoprotein CD44 is overexpressed on most breast cancer cells and is the primary cell surface receptor for hyaluronan (HA). To facilitate breast cancer diagnosis, we report an indocyanine green (ICG) and HA conjugated iron oxide nanoparticle (NP-ICG-HA), which enabled active targeting to breast cancer by HA-CD44 interaction and detected metastasis with magnetic particle imaging (MPI) and near-infrared fluorescence imaging (NIR-FI)...

Staphylococcus aureus ( S. aureus ), a commensal organism found on the human skin, is commonly associated with nosocomial infections and exhibits virulence mediated by toxins and resistance to antibiotics. The global threat of antibiotic resistance has necessitated antimicrobial stewardship to improve the safe and appropriate use of antimicrobials; hence, there is an urgent demand for the advanced, cost-effective, and rapid detection of specific bacteria. In this regard, we aimed to selectively detect S. aureus using surface molecularly imprinted magnetic nanoparticles templated with a well-known biomarker protein A, specific to S...

Numerous pollutants endanger the safety and purity of water, making water pollution a major worldwide concern. The health of people and aquatic ecosystems are at risk from these contaminants, which include hazardous microbes, industrial waste, and agricultural runoff. Fortunately, there appears to be a viable option to address this problem with adsorptive water treatment techniques. The present study presents a magnetic adsorbent (MMIP) based on molecularly imprinted polyaniline and magnetite nanoparticles for the solid-phase extraction of diclofenac, an anti-inflammatory medication, from industrial wastewater...

Within a kinetic theory, the linear magnetic response of uniaxial single-domain particles suspended in a fluid is analyzed. The main qualitatively different types of frequency dependence of the longitudinal dynamic magnetic susceptibility of such particles are described. It is shown that superparamagnetic (related to orientation thermal fluctuations of the magnetic moment inside a particle) peculiarities of the response of a particle to a probing magnetic field are not fully determined by the ratio of anisotropy energy to thermal energy when a stationary bias field is applied...

Bio-inspired magnetic-responsive hydrogel is confined in exceedingly narrow spaces for soft robots and biomedicine in either gel state or magnetofluidic sol state. However, the motion of the gel state magnetic hydrogel will be inhibited in various irregular spaces due to the fixed shape and size and the sol-state magnetofluid gel might bring unpredictable residues in the confined narrow space. Inspired by the dynamic liquid lubricating mechanism of biological systems, novel magnetic-responsive semi-convertible hydrogel (MSCH) was developed through imbedding magnetic-responsive gelatin and amino-modified Fe3 O4 nanoparticles network into the covalent network of polyvinyl alcohol, which can be switched between gel state and gel-sol state in response to magnetic stimuli...

This review focuses on the green synthesis methods, challenges, and applications of manganese oxide (Mn3O4) nanoparticles investigated in the past five years. Mn3O4 nanoparticles offer some unique properties that are attributed in part to the presence of mixed oxidation states of manganese (i.e., +2 and +3) in the particle, which can be utilized in a wide range of redox-sensitive applications, such as in developing supercapacitive energy storage materials. In addition, the green synthesis of Mn3O4 nanoparticles through plant extracts has potential uses in sustainable nanotechnology...

The immobilization of metal ions on inorganic supports has garnered significant attention due to its wide range of applications. These immobilized metal ions serve as catalysts for chemical reactions and as probes for studying biological processes. In this study, we successfully prepared Fe3 O4 @SiO2 @Mn-complex by immobilizing manganese onto the surface of magnetic Fe3 O4 @SiO2 nanoparticles through a layer-by-layer assembly technique. The structure of these hybrid nanoparticles was characterized by various analytical techniques, including Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), and inductively coupled plasma-optical emission spectrometry (ICP-OES)...

Embedding nanoparticles with different functionalities into soft substrates is a convenient tool to realize technologically significant multifunctional materials. This study focuses on incorporating bimetallic plasmonic nanoparticles into soft crystals made of cetyltrimethylammonium bromide-iodide. We observed the emergence of a novel symmetry-lowered cetrimonium crystal polymorph that enables the realization of strong interparticle plasmonic coupling in these composite materials. The observed crystal polymorph exhibits a triclinic structure with significantly reduced unit cell volume compared to standard CTAB...

The integration of preclinical magnetic resonance imaging (MRI) and computed tomography (CT) methods has significantly enhanced the area of therapy and imaging of targeted nanomedicine. Nanotheranostics, which make use of nanoparticles, are a significant advancement in MRI and CT imaging. In addition to giving high-resolution anatomical features and functional information simultaneously, these multifunctional agents improve contrast when used. In addition to enabling early disease detection, precise localization, and personalised therapy monitoring, they also enable early disease detection...

Sustainable development has become an inevitable trend in the world's green chemical industry for a generation or more. In this study, a monodisperse magnetic polystyrene mesoporous composite microsphere (MPPS) composed of Fe3 O4 nanoparticles loaded on polystyrene mesoporous microspheres is introduced. These microspheres serve as effective adsorbents for the swift removal of cationic dyes. The fabrication of the wastewater adsorbent, with its simple operation and economic practicality, involved a combination of dispersion polymerization, a sulfonation reaction, two-step swelling polymerization, and in situ alkaline oxidation technology...

Janus structure plays a crucial role in achieving chemically driven nanomotors with exceptional motion performance. However, Janus-structured chemically driven nanomotors with magnetic responsiveness are commonly fabricated by sputtering metal films. In the study, a self-assembly technique is employed to asymmetrically modify the surfaces of magnetic silica (SiO2 @Fe3 O4 ) nanoparticles with platinum nanoparticles, resulting in the formation of this kind nanomotors. Compared to platinum film, platinum nanoparticles exhibit a larger surface area and a higher catalytic activity...

Gambogic acid is a natural compound with anticancer properties and is effective for many tumors. But its low water solubility and dose-dependent side effects limit its clinical application. This study aims to develop a novel drug delivery system for intratumoral delivery of gambogic acid. In our experimental study, we propose a new method for encapsulating gambogic acid nanoparticles using a manganese composite hyaluronic acid hydrogel as a carrier, designed for targeted drug delivery to tumors. The hydrogel delivery system is synthesized through the coordination of hyaluronic acid-dopamine (HA-DOPA) and manganese ions...

Polymers are extensively used for the realization of drug delivery systems across multiple scales, from nanomedicines to microparticles and macroscopic implantable devices, for their favorable biodegradation profiles and tunable physicochemical features. The accurate quantification of the polymer content is key to finely controlling drug loading and release and ensuring reproducibility, yet it continues to be a major challenge in the design and development of delivery systems. In this study, we introduce a novel protocol based on the PULCON technique to quantify, with a routine NMR spectroscopy analysis, the precise concentration of polymers in various delivery systems...