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JOURNAL ARTICLE
Nanying Wang, Thaís Floriano Marcelino, Carina Ade, Stefan Pendlmayr, Miguel A Ramos Docampo, Brigitte Städler
Nano/micromotors outperform Brownian motion due to their self-propulsive capabilities and hold promise as carriers for drug delivery across biological barriers such as the extracellular matrix. This study employs poly(2-(diethylamino)ethyl methacrylate) polymer brushes to enhance the collagenase-loading capacity of silica particle-based motors with the aim to systematically investigate the impact of gelatine viscosity, motors' size, and morphology on their propulsion velocity. Notably, 500 nm and 1 μm motors achieve similar speeds as high as ∼15 μm s-1 in stiff gelatine-based hydrogels when triggered with calcium...
May 1, 2024: Nanoscale
#2
JOURNAL ARTICLE
Maria Sirenko, Elsa Bernard, Maria Creignou, Dylan Domenico, Andrea Farina, Juan Esteban Arango Ossa, Olivier Kosmider, Robert P Hasserjian, Martin Jädersten, Ulrich Germing, Guillermo F Sanz, Arjan A van de Loosdrecht, Carmelo Gurnari, Matilde Y Follo, Felicitas R Thol, Lurdes Zamora, Andrea Pellagatti, Harold Kunal Elias, Detlef Thomas Haase, Birgitta Sander, Elisa Orna, Katharina Zoldan, Lea Naomi Eder, Wolfgang R Sperr, Renate Thalhammer, Christina Ganster, Lionel Adès, Magnus Tobiasson, Laura Palomo, Matteo Giovanni Della Porta, Kety H Huberman, Pierre Fenaux, Monika Belickova, Michael R Savona, Virginia Klimek, Fabio P S Santos, Jacqueline Boultwood, Ioannis Kotsianidis, Valeria Santini, Francesc Sole, Uwe Platzbecker, Michael Heuser, Peter Valent, Carlo Finelli, Maria Teresa Voso, Lee Yung Shih, Seishi Ogawa, Michaela Fontenay, Joop H Jansen, José Cervera, Benjamin L Ebert, Rafael Bejar, Peter L Greenberg, Norbert Gattermann, Luca Malcovati, Mario Cazzola, David B Beck, Eva S Hellstrom-Lindberg, Elli Papaemmanuil, Ronald Feitosa Pinheiro
Mutations in UBA1, which are disease-defining for VEXAS syndrome, have been reported in patients diagnosed with myelodysplastic syndromes (MDS). Here, we define the prevalence and clinical associations of UBA1 mutations in a representative cohort of patients with MDS. Digital droplet PCR profiling of a selected cohort of 375 male patients lacking MDS disease-defining mutations or established WHO disease classification identified 28 patients (7%) with UBA1 p.M41T/V/L mutations. Using targeted sequencing of UBA1 in a representative MDS cohort (n=2,027), we identified an additional 27 variants in 26 patients (1%), which we classified as likely/pathogenic (n=12) and unknown significance (n=15)...
April 30, 2024: Blood
#3
JOURNAL ARTICLE
Yong He, Lilin Zhong, Hailing Yan, Maria Luisa Virata, Lu Deng, Ashish K Mishra, Evi Struble, Dorothy Scott, Pei Zhang
Human immunoglobulin preparations contain a diverse range of polyclonal antibodies that reflect past immune responses against pathogens encountered by the blood donor population. In this study, we examined a panel of intravenous immunoglobulins (IGIVs) manufactured over the past two decades (1998-2020) for their capacity to neutralize or enhance Zika virus (ZIKV) infection in vitro . These IGIVs were selected specifically based on their production dates in relation to the occurrences of two flavivirus outbreaks in the U...
April 30, 2024: Microbiology Spectrum
#4
JOURNAL ARTICLE
Jing Wang, Guowen Feng, Dan Li, Xiaodan Zhou, Jia Chen, Fengdie Wang, Li Chen
OBJECTIVE: To investigate adverse events(ADEs) associated with the use of paracetamol and ibuprofen in people under 18 years of age. BACKGROUND: The use of NSAIDs reached a peak as a result of the spread of COVID-19 in previous years. Minors, as a special population, need to pay more attention to the use of corresponding drugs and the occurrence of adverse events (ADEs). METHODS: The population was divided into four age groups: infant group, preschool group, children group, and adolescent group...
April 30, 2024: Expert Opinion on Drug Safety
#5
JOURNAL ARTICLE
Mikaël de Lorenzi-Tognon, Jacques Schrenzel
Antimicrobial/antibiotic de-escalation (ADE) is a key feature of antimicrobial stewardship programs (ASP) that relies mainly on individual panels for determining ADE events based on subjective ranking of antibiotics' spectrum activity. The lack of consensus among ASP experts leads to reproducibility issues in the measure of this clinical outcome, making difficult to assess its real impact on patient care. The S3 score (Simplified Spectrum Score) app was developed to allow an objective ranking of antibiotics...
April 29, 2024: Scientific Reports
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JOURNAL ARTICLE
María Del Rocío Hernández-Morales, Jorge Manuel Ramírez-Sánchez, Eleazar Mancilla-Hernández, Norma Lara-Dávalos, Samara Nazarala-Sanchez, Margarita Aguirre-Barbosa
OBJECTIVE: To determine prevalence, causes and risk factors of ADE in hospitalized patients. METHODS: Analytical, observational, case-control study of patients with ADE. For statistical analysis, the following were calculated: percentages, frequencies, averages; odds ratio, χ2 test and multiple binary logistic regression. Data analysis was carried out with the Statistical Package, for the Social Sciences 23 program. RESULTS: A 132 patients were registered: 66 cases (26 EM and 40 RAM) and 66 controls; with average age of 35 years (SD 17...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#7
JOURNAL ARTICLE
Swapna Thomas, Maria K Smatti, Haya Alsulaiti, Hadeel T Zedan, Ali H Eid, Ali A Hssain, Laith J Abu Raddad, Giusy Gentilcore, Allal Ouhtit, Asmaa A Althani, Gheyath K Nasrallah, Jean-Charles Grivel, Hadi M Yassine
This study evaluated the potential for antibody-dependent enhancement (ADE) in serum samples from patients exposed to Middle East respiratory syndrome coronavirus (MERS-CoV). Furthermore, we evaluated the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination on ADE in individuals with a MERS infection history. We performed ADE assay in sera from MERS recovered and SARS-CoV-2-vaccinated individuals using BHK cells expressing FcgRIIa, SARS-CoV-2, and MERS-CoV pseudoviruses (PVs). Further, we analyzed the association of ADE to serum IgG levels and neutralization...
May 2024: Journal of Medical Virology
#8
JOURNAL ARTICLE
YuBin He, Xin Guan, YaYun Zhang, Zixiong Zhu, YanHui Zhang, Yue Feng, Xuewen Li
BACKGROUND: our study aimed to identify inclisiran-related adverse events(AEs) for primary hypercholesterolemia and arteriosclerotic cardiovascular disease(ASCVD) from the US FDA Adverse Event Reporting System (FAERS) database, analyzing its links to AEs in the overall patient population and sex-specific subgroups to improve medication safety. METHODS: We analyzed inclisiran-related AEs signals by using statistical methods like Reporting Odds Ratio (ROR), Proportional Reporting Ratios (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-item Gamma-Poisson Shrinker (MGPS)...
April 27, 2024: Expert Opinion on Drug Safety
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JOURNAL ARTICLE
Eliseo Vano, Roberto M Sanchez Casanueva, Jose M Fernandez Soto, Jose I Ten Moron
Occupational protection could be improved in interventional radiology. The monthly personal dosimetry cannot alert on some occupational doses with anomalous values for certain procedures. Active electronic personal dosimeters linked wireless to a dose management system (DMS), allow for the measurement of occupational doses per procedure, integrating this information with patient dose indicators and with technical and geometrical conditions of the procedures. We analysed around 3100 occupational dose values for individual procedures collected during the last two years, in an interventional radiology laboratory of a University Hospital and two groups, with patient doses higher than 100 Gy...
April 25, 2024: Physica Medica: PM
#10
JOURNAL ARTICLE
Yaxuan Wu, Ming Tan, Yanling Gao, Na Geng, Weibin Zhong, Hairong Sun, Zhenguang Li, Chenxi Wu, Xuemei Li, Jinbiao Zhang
BACKGROUND: The complement system plays crucial roles in cognitive impairment and acute ischemic stroke (AIS). High levels of complement proteins in plasma astrocyte-derived exosomes (ADEs) were proven to be associated with Alzheimer's disease. We aimed to investigate the relationship of complement proteins in serum ADEs with poststroke cognitive impairment in type 2 diabetes mellitus (T2DM) patients. METHODS: This study analyzed 197 T2DM patients who suffered AIS...
April 19, 2024: Journal of Alzheimer's Disease: JAD
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REVIEW
Eloisa Sofia Tanzarella, Salvatore Lucio Cutuli, Gianmarco Lombardi, Fabiola Cammarota, Alessandro Caroli, Emanuele Franchini, Elena Sancho Ferrando, Domenico Luca Grieco, Massimo Antonelli, Gennaro De Pascale
Antimicrobial de-escalation (ADE) is defined as the discontinuation of one or more antimicrobials in empirical therapy, or the replacement of a broad-spectrum antimicrobial with a narrower-spectrum antimicrobial. The aim of this review is to provide an overview of the available literature on the effectiveness and safety of ADE in critically ill patients, with a focus on special conditions such as anti-fungal therapy and high-risk categories. Although it is widely considered a safe strategy for antimicrobial stewardship (AMS), to date, there has been no assessment of the effect of de-escalation on the development of resistance...
April 19, 2024: Antibiotics
#12
JOURNAL ARTICLE
Marisa Dwi Ariani, Ade Zuhrotun, Panagiotis Manesiotis, Aliya Nur Hasanah
Kaempferia galanga rhizome is traditionally used as a treatment for various diseases. Ethyl p -methoxycinnamate (EPMC), which constitutes up to 31.77% of the total essential oil, is the main/marker compound. EPMC is responsible for various pharmacological activities of Kaempferia galanga rhizome. According to the existing research, the isolation yield of EPMC is still meager, namely 0.50-2.50%; thus, a new EPMC isolation method is needed to produce better results. In this study, after determining the association constant and obtaining the Jobs plot between methacrylate derivative monomers and EPMC, a molecularly imprinted polymer for solid phase extraction (MI-SPE) was synthesized through bulk polymerization with EPMC as a template, methacrylic acid as a monomer, TRIM/EDGMA as a crosslinker in a ratio of 1 : 4 : 20 (MIP1) or 1 : 7 : 20 (MIP2)...
April 22, 2024: RSC Advances
#13
JOURNAL ARTICLE
Hammad Hussain, Guillaume Dutilleux
Sine sweeps are widely used as test signals in the experimental characterisation of linear and non-linear acoustical systems' responses. One of the reasons for their popularity is that their immunity against time variance is assumed to be superior to that of other types of test signals. This paper explores and quantifies the consequences of linear time variance on the characterisation of acoustical systems with linear sweeps. The first result is a novel compact closed-form expression for the spectrum of a linear sweep...
April 1, 2024: Journal of the Acoustical Society of America
#14
JOURNAL ARTICLE
Eiman Eltayeb M Ibrahim, Safaa Badi, Bashir A Yousef, LutzBashir A Elsayed, Habab K Elkheir
BACKGROUND: Anti-retroviral therapy-related adverse drug events are accounted as a main cause of anti-retroviral therapy non-adherence. In Sudan, pharmacovigilance studies are relatively rare and obstructed by the problem of under-reporting. It is a well-defined issue worldwide and is highly reported in developing countries. This study aimed to evaluate the prevalence of adverse events associated with anti-retroviral therapy among adult patients with immunodeficiency virus at Omdurman Voluntary Counselling and Testing and Anti-retroviral Therapy Center...
2024: HIV/AIDS: Research and Palliative Care
#15
REVIEW
Elena Figuero, Mervi Gürsoy, Virginie Monnet-Corti, Margarita Iniesta, Angeline Antezack, Ines Kapferer-Seebacher, Christian Graetz, Yuval Vered, Andreas Stavropoulos, Asaf Wilensky, Peter Eickholz, Mariano Sanz
AIM: This review is intended to adapt the current conceptual framework in dental education based on four domains to propose a set of competences, learning outcomes and methods of teaching, learning and assessment for undergraduate education in periodontology. REVIEW: Based on the current framework of competences and learning outcomes recommended by the Association for Dental Education in Europe (ADEE), undergraduate education in periodontology has been updated using the classification and clinical practice guidelines for the diagnosis and treatment of periodontal and peri-implant diseases...
April 24, 2024: Journal of Clinical Periodontology
#16
JOURNAL ARTICLE
Yunyan Pan, Yu Wang, Yifan Zheng, Jie Chen, Jia Li
BACKGROUND: Ticagrelor is a commonly used antiplatelet agent, but due to the stringent criteria for trial population inclusion and the limited sample size, its safety profile has not been fully elucidated. METHOD: We utilized OpenVigil 2.1 to query the FDA Adverse Event Reporting System database and retrieved reports by the generic name "ticagrelor" published between 1 October 2010 and 31 March 2023. Adverse drug events (ADEs) were classified and described according to the preferred terms and system organ classes in the Medical Dictionary of Regulatory Activity...
2024: Frontiers in Pharmacology
#17
JOURNAL ARTICLE
Daniel Thoresen, Kenta Matsuda, Akane Urakami, Mya Myat Ngwe Tun, Takushi Nomura, Meng Ling Moi, Yuri Watanabe, Momoko Ishikawa, Trang Thi Thu Hau, Hiroyuki Yamamoto, Yuriko Suzaki, Yasushi Ami, Jonathan F Smith, Tetsuro Matano, Kouichi Morita, Wataru Akahata
Dengue virus (DENV) represents a significant global health burden, with 50% of the world's population at risk of infection, and there is an urgent need for next-generation vaccines. Virus-like particle (VLP)-based vaccines, which mimic the antigenic structure of the virus but lack the viral genome, are an attractive approach. Here, we describe a dengue VLP (DENVLP) vaccine which generates a neutralizing antibody response against all four DENV serotypes in 100% of immunized non-human primates for up to 1 year...
April 22, 2024: Journal of Virology
#18
JOURNAL ARTICLE
Zhi-Liang Duan, Wei-Wei Zou, Dong Chen, Jia-Yang Zhu, Jin-Sheng Wen
Zika virus (ZIKV) and Japanese encephalitis virus (JEV) are antigenically related flaviviruses that co-circulate in many countries/territories. The interaction between the two viruses needs to be determined. Recent findings by ourselves and other labs showed that JEV-elicited antibodies (Abs) and CD8+ T cells exacerbate and protect against subsequent ZIKV infection, respectively. However, the impact of JEV envelope (E) protein domain III (EDIII)-induced immune responses on ZIKV infection is unclear. We show here that sera from JEV-EDIII-vaccinated mice cross-react with ZIKV-EDIII in vitro, and transfer of the same sera to mice significantly decreases death upon lethal ZIKV infection at a dose-dependent manner...
April 19, 2024: Virus Research
#19
JOURNAL ARTICLE
Mariska Snelleman, Myrthe Wessel, Adee Schoon
Detection dogs are frequently tested for their ability to detect a variety of targets. It is crucial to comprehend the processes for odour learning and the consequences of training on an expanding set of target scents on performance. To properly evaluate their ability to identify the target, the only true measure is the dogs' initial response to novel sources, since this excludes learning effects. In this study, we evaluated the individual learning processes of three detection dogs that were pre-trained to differentially respond to a faecal sample of a mare in oestrus (S+) and a faecal sample of the same mare in di-oestrus (S-)...
April 16, 2024: Behavioural Processes
#20
JOURNAL ARTICLE
Achmad Faturrahman Jundi, M Dlorifun Naqiyyun, Bisma Barron Patrianesha, Intan A S Mu'minah, Ade Riana, Deni Hardiansyah
PURPOSE: Calculation of the uncertainty of the individual time-integrated activity coefficient (TIACs) is desirable in molecular radiotherapy. However, the calculation of TIAC's uncertainty in single-time-point (STP) method has never been reported in the literature. This study presents a method based on the Bayesian fitting (BF) to calculate the standard deviation (SD) of individual TIACs in the STP dosimetry. METHODS: Biokinetic data of 177 Lu-DOTATATE in kidneys were obtained from PMID33443063...
May 2024: Nuclear Medicine and Molecular Imaging
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