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JOURNAL ARTICLE
Yunna Li, Yiming Wang, Liang Kou, Sijia Yin, Xiaosa Chi, Yadi Sun, Jiawei Wu, Zongjie Jin, Qiulu Zhou, Wenkai Zou, Tao Wang, Yun Xia
INTRODUCTION: Microglia are the main phagocytes in the brain and can induce neuroinflammation. Moreover, they are critical to alpha-synuclein (α-syn) aggregation and propagation. Plasma exosomes derived from patients diagnosed with Parkinson's disease (PD-exo) reportedly evoked α-syn aggregation and inflammation in microglia. In turn, microglia internalized and released exosomal α-syn, enhancing α-syn propagation. However, the specific mechanism through which PD-exo influences α-syn degradation remains unknown...
May 2024: CNS Neuroscience & Therapeutics
#2
JOURNAL ARTICLE
Ren Zhou, Fei Chen, Lei Zhang, Yu Sun, Rong Hu, Jia Yan, Hong Jiang
BACKGROUND: High salt intake has been proposed as a risk factor for dementia. However, causal relationship between salt intake and dementia remains uncertain. PURPOSE: The aim of this study was to employ a mendelian randomization (MR) design to investigate the causal impact of salt intake on the risk of dementia. METHODS: Genome-wide association study (GWAS) data of exposures and outcomes (any dementia, cognitive performance, different types of dementia, Alzheimer's disease [AD], and Parkinson's disease) were obtained from the IEU database...
May 2024: Brain and Behavior
#3
JOURNAL ARTICLE
Guanyu Zhang, Jinghong Ma, Piu Chan, Zheng Ye
PURPOSE: Sequential working memory is the ability to maintain and manipulate sequential information at a second time scale. Patients with progressive supranuclear palsy (PSP) or Parkinson's disease (PD) perform poorly in tests that require the flexible arrangement of thoughts or actions. This study investigated whether sequential working memory is differently impaired in patients with PSP versus PD. METHOD: Twenty-nine patients with PSP Richardson's syndrome (PSP-RS), 36 patients with PD, and 36 healthy controls (HC) completed 3 well-established neuropsychological tests, including digit span forward (DST-F), digit span backward (DST-B), and adaptive digit ordering tests (DOT-A)...
May 2024: Brain and Behavior
#4
JOURNAL ARTICLE
Sofiya Maltseva, Daniel Kerr, Miah Turke, Erin J Adams, Ka Yee C Lee
Lipid binding properties of α-synuclein play a central role in protein aggregation and progression of Parkinson's Disease (PD). α-Synuclein, an intrinsically disordered protein, binds to lipid membranes through the formation of two amphipathic helices that insert into the lipid bilayer. All disease-associated single point mutations have been identified to be within these helical regions of α-synuclein: V15A, A30P, E46K, H50Q, G51D, A53T, and A53V. However, the effects of these mutations on the bound states of the two α-helices of the protein have yet to be fully characterized...
May 2, 2024: Biophysical Journal
#5
JOURNAL ARTICLE
Joseph Mifsud, Kyle R Embry, Rebecca Macaluso, Luca Lonini, R James Cotton, Tanya Simuni, Arun Jayaraman
BACKGROUND: Neurodegenerative diseases, such as Parkinson's disease (PD), necessitate frequent clinical visits and monitoring to identify changes in motor symptoms and provide appropriate care. By applying machine learning techniques to video data, automated video analysis has emerged as a promising approach to track and analyze motor symptoms, which could facilitate more timely intervention. However, existing solutions often rely on specialized equipment and recording procedures, which limits their usability in unstructured settings like the home...
May 3, 2024: Journal of Neuroengineering and Rehabilitation
#6
JOURNAL ARTICLE
Aleš Holfeld, Dina Schuster, Fabian Sesterhenn, Alison K Gillingham, Patrick Stalder, Walther Haenseler, Inigo Barrio-Hernandez, Dhiman Ghosh, Jane Vowles, Sally A Cowley, Luise Nagel, Basavraj Khanppnavar, Tetiana Serdiuk, Pedro Beltrao, Volodymyr M Korkhov, Sean Munro, Roland Riek, Natalie de Souza, Paola Picotti
The physical interactome of a protein can be altered upon perturbation, modulating cell physiology and contributing to disease. Identifying interactome differences of normal and disease states of proteins could help understand disease mechanisms, but current methods do not pinpoint structure-specific PPIs and interaction interfaces proteome-wide. We used limited proteolysis-mass spectrometry (LiP-MS) to screen for structure-specific PPIs by probing for protease susceptibility changes of proteins in cellular extracts upon treatment with specific structural states of a protein...
May 3, 2024: Molecular Systems Biology
#7
JOURNAL ARTICLE
Yang Yang, Xiaoying Tian, Pengfei Sun, Xiaoli Zhao, Jintian Hu, Bo Pan
The main objective of this study was to investigate the incidence and characteristics of electrocardiographic abnormalities in patients with microtia, and to explore cardiac maldevelopment associated with microtia. This retrospective study analyzed a large cohort of microtia patients admitted to Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, from September 2017 to August 2022. The routine electrocardiographic reports of these patients were reviewed to assess the incidence and characteristics of abnormalities...
May 3, 2024: Scientific Reports
#8
JOURNAL ARTICLE
Thomas F Tropea, Whitney Hartstone, Noor Amari, Dylan Baum, Jacqueline Rick, Eunran Suh, Hanwen Zhang, Rachel A Paul, Noah Han, Rebecca Zack, Eliza M Brody, Isabela Albuja, Justin James, Meredith Spindler, Andres Deik, Whitley W Aamodt, Nabila Dahodwala, Ali Hamedani, Aaron Lasker, Howard Hurtig, Matthew Stern, Daniel Weintraub, Pavan Vaswani, Allison W Willis, Andrew Siderowf, Sharon X Xie, Vivianna Van Deerlin, Alice S Chen-Plotkin
Observational studies in Parkinson's disease (PD) deeply characterize relatively small numbers of participants. The Molecular Integration in Neurological Diagnosis Initiative seeks to characterize molecular and clinical features of every PD patient at the University of Pennsylvania (UPenn). The objectives of this study are to determine the feasibility of genetic characterization in PD and assess clinical features by sex and GBA1/LRRK2 status on a clinic-wide scale. All PD patients with clinical visits at the UPenn PD Center between 9/2018 and 12/2022 were eligible...
May 3, 2024: NPJ Parkinson's Disease
#9
JOURNAL ARTICLE
Michele Matarazzo, Alexandra Pérez-Soriano, Nasim Vafai, Elham Shahinfard, Kevin Ju-Chieh Cheng, Jessamyn McKenzie, Nicole Neilson, Qing Miao, Paul Schaffer, Hitoshi Shinotoh, Jeffrey H Kordower, Vesna Sossi, A Jon Stoessl
Parkinson's disease (PD) is associated with aggregation of misfolded α-synuclein and other proteins, including tau. We designed a cross-sectional study to quantify the brain binding of [11 C]PBB3 (a ligand known to bind to misfolded tau and possibly α-synuclein) as a proxy of misfolded protein aggregation in Parkinson's disease (PD) subjects with and without cognitive impairment and healthy controls (HC). In this cross-sectional study, nineteen cognitively normal PD subjects (CN-PD), thirteen cognitively impaired PD subjects (CI-PD) and ten HC underwent [11 C]PBB3 PET...
May 3, 2024: NPJ Parkinson's Disease
#10
JOURNAL ARTICLE
Sara Bohid, Lara Kamal Ali, Cesar Ramon Romero-Leguizamón, Annette E Langkilde, Altair Brito Dos Santos, Kristi A Kohlmeier
Parkinson's Disease (PD) patients experience sleeping disorders in addition to the disease-defining symptomology of movement dysfunctions. The prevalence of PD is sex-based and presence of sleeping disorders in PD also shows sex bias with a stronger phenotype in males. In addition to loss of dopamine-containing neurons in the striatum, arousal-related, orexin-containing neurons in the lateral hypothalamus (LH) are lost in PD, which could contribute to state-related disorders. As orexin has been shown to be involved in sleeping disorders and to have neuroprotective effects, we asked whether orexin could protect sleep-related LH neurons from damage putatively from the protein α-synuclein (α-syn), which is found at high levels in the PD brain and that we have shown is associated with putatively excitotoxic rises in intracellular calcium in brainstem sleep-controlling nuclei, especially in males...
May 1, 2024: Molecular and Cellular Neurosciences
#11
JOURNAL ARTICLE
Fatemeh Tabari, Celeste Patron, Hope Cryer, Karim Johari
The supplementary motor area (SMA) is implicated in planning, execution, and control of speech production and limb movement. The SMA is among putative generators of pre-movement EEG activity which is thought to be neural markers of motor planning. In neurological conditions such as Parkinson's disease, abnormal pre-movement neural activity within the SMA has been reported during speech production and limb movement. Therefore, this region can be a potential target for non-invasive brain stimulation for both speech and limb movement...
May 1, 2024: International Journal of Psychophysiology
#12
JOURNAL ARTICLE
Ruth Chia, Anindita Ray, Zalak Shah, Jinhui Ding, Paola Ruffo, Masashi Fujita, Vilas Menon, Sara Saez-Atienzar, Paolo Reho, Karri Kaivola, Ronald L Walton, Regina H Reynolds, Ramita Karra, Shaimaa Sait, Fulya Akcimen, Monica Diez-Fairen, Ignacio Alvarez, Alessandra Fanciulli, Nadia Stefanova, Klaus Seppi, Susanne Duerr, Fabian Leys, Florian Krismer, Victoria Sidoroff, Alexander Zimprich, Walter Pirker, Olivier Rascol, Alexandra Foubert-Samier, Wassilios G Meissner, François Tison, Anne Pavy-Le Traon, Maria Teresa Pellecchia, Paolo Barone, Maria Claudia Russillo, Juan Marín-Lahoz, Jaime Kulisevsky, Soraya Torres, Pablo Mir, Maria Teresa Periñán, Christos Proukakis, Viorica Chelban, Lesley Wu, Yee Y Goh, Laura Parkkinen, Michele T Hu, Christopher Kobylecki, Jennifer A Saxon, Sara Rollinson, Emily Garland, Italo Biaggioni, Irene Litvan, Ileana Rubio, Roy N Alcalay, Kimberly T Kwei, Steven J Lubbe, Qinwen Mao, Margaret E Flanagan, Rudolph J Castellani, Vikram Khurana, Alain Ndayisaba, Andrea Calvo, Gabriele Mora, Antonio Canosa, Gianluca Floris, Ryan C Bohannan, Anni Moore, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma, Horacio Kaufmann, Changyoun Kim, Michiyo Iba, Eliezer Masliah, Ted M Dawson, Liana S Rosenthal, Alexander Pantelyat, Marilyn S Albert, Olga Pletnikova, Juan C Troncoso, Jon Infante, Carmen Lage, Pascual Sánchez-Juan, Geidy E Serrano, Thomas G Beach, Pau Pastor, Huw R Morris, Diego Albani, Jordi Clarimon, Gregor K Wenning, John A Hardy, Mina Ryten, Eric Topol, Ali Torkamani, Adriano Chiò, David A Bennett, Philip L De Jager, Philip A Low, Wolfgang Singer, William P Cheshire, Zbigniew K Wszolek, Dennis W Dickson, Bryan J Traynor, J Raphael Gibbs, Clifton L Dalgard, Owen A Ross, Henry Houlden, Sonja W Scholz
Multiple system atrophy (MSA) is an adult-onset, sporadic synucleinopathy characterized by parkinsonism, cerebellar ataxia, and dysautonomia. The genetic architecture of MSA is poorly understood, and treatments are limited to supportive measures. Here, we performed a comprehensive analysis of whole genome sequence data from 888 European-ancestry MSA cases and 7,128 controls to systematically investigate the genetic underpinnings of this understudied neurodegenerative disease. We identified four significantly associated risk loci using a genome-wide association study approach...
April 24, 2024: Neuron
#13
JOURNAL ARTICLE
Dorian Vogel, Teresa Nordin, Stefanie Feiler, Karin Wardell, Jérôme Coste, Jean-Jacques Lemaire, Simone Hemm-Ode
Deep brain stimulation (DBS) is a therapy for Parkinson's disease (PD) and essential tremor (ET). The mechanism of action of DBS is still incompletely understood. Retrospective group analysis of intra-operative data recorded from ET patients implanted in the ventral intermediate nucleus of the thalamus (Vim) is rare. Intra-operative stimulation tests generate rich data and their use in group analysis has not yet been explored. 

Objective: To implement, evaluate, and apply a group analysis workflow to generate probabilistic stimulation maps (PSM) using intra-operative stimulation data from ET patients implanted in Vim...
May 3, 2024: Journal of Neural Engineering
#14
JOURNAL ARTICLE
Chiara Longo, Daniele Luigi Romano, Maria Pennacchio, Maria Chiara Malaguti, Raffaella Di Giacopo, Bruno Giometto, Costanza Papagno
BACKGROUND: Mild cognitive impairment in Parkinson's disease (PD-MCI) includes deficits in different cognitive domains, and one domain to explore for neurocognitive impairment following the DSM-V is social cognition. However, this domain is not included in current criteria for PD-MCI diagnosis. Moreover, tests vary across studies. It is, therefore, crucial to optimize cognitive assessment in PD-MCI. We aimed to do so by using Machine Learning. METHODS: 275 PD patients were included...
April 30, 2024: Parkinsonism & related Disorders
#15
JOURNAL ARTICLE
Yoya Ono, Koh Tadokoro, Taijun Yunoki, Toru Yamashita, Daisuke Sato, Hiroyasu Sato, Shintaro Akamatsu, Heisuke Mizukami, Yasuyuki Ohta, Yoshihisa Yamano, Akio Kimura, Shimohata Takayoshi
INTRODUCTION: Anti-immunoglobulin-like cell adhesion molecule 5 (IgLON5) disease is a rare autoimmune encephalitis that can mimic progressive supranuclear palsy or corticobasal syndrome. Moreover, anti-IgLON5 disease can present with symptoms characteristic of multiple system atrophy (MSA), such as cerebellar ataxia and autonomic dysfunction. However, the clinical features of anti-IgLON5 disease resembling MSA have not been well established. METHODS: We enrolled 35 patients with suspected MSA for whom anti-IgLON5 antibody tests were requested...
April 30, 2024: Parkinsonism & related Disorders
#16
JOURNAL ARTICLE
Bowen Chang, Jiaming Mei, Chen Ni, Peng Chen, Yuge Jiang, Chaoshi Niu
BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder that is predominantly known for its motor symptoms but is also accompanied by non-motor symptoms, including anxiety. OBJECTIVE: The underlying neurobiological substrates and brain network changes associated with comorbid anxiety in PD require further exploration. METHODS: An analysis of oscillation-specific nodal properties in patients with and without anxiety was conducted using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory...
April 29, 2024: Journal of Parkinson's Disease
#17
JOURNAL ARTICLE
Marie-Louise Zeissler, Nikul Bakshi, Michèle Bartlett, Amit Batla, David Byrom, Rebecca Chapman, Sally Collins, Elaine Cowd, Eric Deeson, Romy Ellis-Doyle, Jodie Forbes, Cristina Gonzalez-Robles, Anna Jewell, Emma L Lane, Nancy R LaPelle, Keith Martin, Helen Matthews, Laurel Miller, Georgia Mills, Antony Morgan, Miriam Parry, Kuhan Pushparatnam, Natasha Ratcliffe, Dorothy Salathiel, Paula Scurfield, Carroll Siu, Sue Whipps, Sheila Wonnacott, Thomas Foltynie, Camille B Carroll, Kevin McFarthing
BACKGROUND: Patient and public involvement and engagement (PPIE) in the design of trials is important, as participant experience critically impacts delivery. The Edmond J Safra Accelerating Clinical Trials in PD (EJS ACT-PD) initiative is a UK consortium designing a platform trial for disease modifying therapies in PD. OBJECTIVE: The integration of PPIE in all aspects of trial design and its evaluation throughout the project. METHODS: PwP and care partners were recruited to a PPIE working group (WG) via UK Parkinson's charities, investigator patient groups and participants of a Delphi study on trial design...
April 27, 2024: Journal of Parkinson's Disease
#18
JOURNAL ARTICLE
Carmen Lage, Antonio Sánchez-Rodríguez, María Rivera-Sánchez, María Sierra, Isabel González-Aramburu, Jorge Madera, Manuel Delgado-Alvarado, Sara López-García, Francisco Martínez-Dubarbie, Marta Fernández-Matarrubia, Néstor Martínez-Amador, Isabel Martínez-Rodríguez, Alberto Calvo-Córdoba, Eloy Rodríguez-Rodríguez, Cecilia García-Cena, Pascual Sánchez-Juan, Jon Infante
BACKGROUND: Video-oculography constitutes a highly-sensitive method of characterizing ocular movements, which could detect subtle premotor changes and contribute to the early diagnosis of Parkinson's disease (PD). OBJECTIVE: To investigate potential oculomotor differences between idiopathic PD (iPD) and PD associated with the G2019S variant of LRRK2 (L2PD), as well as to evaluate oculomotor function in asymptomatic carriers of the G2019S variant of LRRK2. METHODS: The study enrolled 129 subjects: 30 PD (16 iPD, 14 L2PD), 23 asymptomatic carriers, 13 non-carrier relatives of L2PD patients, and 63 unrelated HCs...
May 2, 2024: Journal of Parkinson's Disease
#19
JOURNAL ARTICLE
Annie Bane, Lorraine Wilson, Jill Jumper, Lindsay Spindler, Pricilla Wyatt, Darryn Willoughby
BACKGROUND: Autonomic dysfunction precedes endothelial dysfunction in Parkinson's disease (PD) and causes blood pressure and circulation abnormalities that are highly disruptive to one's quality of life. While exercise interventions have proven helpful for motor symptoms of PD, improving associated non-motor symptoms is limited. Low-intensity resistance training with blood flow restriction (LIRT-BFR) improves autonomic dysfunction in non-PD patients and high-intensity resistance training (HIRT) is recommended for motor symptom improvements for people with PD (PwPD)...
April 27, 2024: Journal of Parkinson's Disease
#20
JOURNAL ARTICLE
Murumulla Lokesh, Lakshmi Jaya Madhuri Bandaru, Ajumeera Rajanna, Virendra Singh Dhayal, Suresh Challa
Neurodegeneration in conditions like Alzheimer's and Parkinson's disease is influenced by genetic and environmental factors. This study explores the potential neurodegenerative effects of lead (Pb) toxicity and amyloid beta peptides (Aβp 1-40 and Aβp 25-35) by promoting M1 polarization in microglial cells. To this end, we investigated and observed that IC50 concentrations of Pb (22.8 μM) and Aβp 25-35(29.6 μM). Our results demonstrated significant Pb uptake (31.13% at 25 μM Pb) and increased intracellular ROS levels (77...
May 3, 2024: Environmental Toxicology
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