Martin K Himmelbauer, Bekim Bajrami, Rebecca Basile, Andrew Capacci, TeYu Chen, Colin K Choi, Rab Gilfillan, Felix Gonzalez-Lopez de Turiso, Chungang Gu, Marc Hoemberger, Douglas S Johnson, J Howard Jones, Ekta Kadakia, Melissa Kirkland, Edward Y Lin, Ying Liu, Bin Ma, Tom Magee, Srinivasa Mantena, Isaac E Marx, Claire M Metrick, Michael Mingueneau, Paramasivam Murugan, Cathy A Muste, Prasad Nadella, Marta Nevalainen, Chelsea R Parker Harp, Vatee Pattaropong, Alicia Pietrasiewicz, Robin J Prince, Thomas J Purgett, Joseph C Santoro, Jurgen Schulz, Simone Sciabola, Hao Tang, H George Vandeveer, Ti Wang, Zain Yousaf, Christopher J Helal, Brian T Hopkins
Multiple sclerosis (MS) is a chronic disease with an underlying pathology characterized by inflammation-driven neuronal loss, axonal injury, and demyelination. Bruton's tyrosine kinase (BTK), a nonreceptor tyrosine kinase and member of the TEC family of kinases, is involved in the regulation, migration, and functional activation of B cells and myeloid cells in the periphery and the central nervous system (CNS), cell types which are deemed central to the pathology contributing to disease progression in MS patients...
May 7, 2024: Journal of Medicinal Chemistry