Gretsen Velezmoro Jauregui, Dragana Vukić, Isaac G Onyango, Carlos Arias, Jan S Novotný, Kateřina Texlová, Shanshan Wang, Kristina Locker Kovačovicova, Natalie Polakova, Jana Zelinkova, Maria Čarna, Valentina Lacovich, Brian P Head, Daniel Havas, Martin Mistrik, Robert Zorec, Alexei Verkhratsky, Liam Keegan, Mary A O'Connell, Robert Rissman, Gorazd B Stokin
AIM: Astrocytes respond to stressors by acquiring a reactive state characterized by changes in their morphology and function. Molecules underlying reactive astrogliosis, however, remain largely unknown. Given that several studies observed increase in the Amyloid Precursor Protein (APP) in reactive astrocytes, we here test whether APP plays a role in reactive astrogliosis. METHODS: We investigated whether APP instigates reactive astroglios by examining in vitro and in vivo the morphology and function of naive and APP-deficient astrocytes in response to APP and well-established stressors...
April 8, 2024: Acta Physiologica