Corina R Ronneberg, Nan Lv, Olusola A Ajilore, Thomas Kannampallil, Joshua Smyth, Vikas Kumar, Amruta Barve, Claudia Garcia, Sushanth Dosala, Nancy Wittels, Lan Xiao, Gbenga Aborisade, Aifeng Zhang, Zhengxin Tang, Jillian Johnson, Jun Ma
BACKGROUND: Novel and scalable psychotherapies are urgently needed to address the depression and anxiety epidemic. Leveraging artificial intelligence (AI), a voice-based virtual coach named Lumen was developed to deliver problem solving treatment (PST). The first pilot trial showed promising changes in cognitive control measured by functional neuroimaging and improvements in depression and anxiety symptoms. METHODS: To further validate Lumen in a 3-arm randomized clinical trial, 200 participants with mild-to-moderate depression and/or anxiety will be randomly assigned in a 2:1:1 ratio to receive Lumen-coached PST, human-coached PST as active treatment comparison, or a waitlist control condition where participants can receive Lumen after the trial period...
May 17, 2024: Contemporary Clinical Trials