Qing Zhang, Lin Shi, Hong He, Xingmou Liu, Yong Huang, Dan Xu, Mengyun Yao, Ning Zhang, Yicheng Guo, Yifei Lu, Haisheng Li, Junyi Zhou, Jianglin Tan, Malcolm Xing, Gaoxing Luo
Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue dysfunction. This study reports a minimally invasive and convenient approach to obtaining scarless tissue using a silk fibroin microneedle patch (SF MNs). We found that by tuning the MN size and density only, the biocompatible MNs significantly decreased the scar elevation index in the rabbit ear hypertrophic scar model and increased ultimate tensile strength close to regular skin...
July 26, 2022: ACS Nano