Bożena Sosnowska, Janina Stepinska, Przemyslaw Mitkowski, Agata Bielecka-Dabrowa, Beata Bobrowska, Jan Budzianowski, Pawel Burchardt, Krzysztof Chlebus, Piotr Dobrowolski, Mariusz Gasior, Piotr Jankowski, Jacek Kubica, Agnieszka Mickiewicz, Malgorzata Mysliwiec, Tadeusz Osadnik, Aleksander Prejbisz, Renata Rajtar-Salwa, Kristian Wita, Adam Witkowski, Robert Gil, Maciej Banach
Lipoprotein(a) [Lp(a)] is made up of a low-density lipoprotein (LDL) particle and a specific apolipoprotein(a). The blood concentration of Lp(a) is approximately 90% genetically determined, and the main genetic factor determining Lp(a) levels is the size of the apo(a) isoform, which is determined by the number of KIV2 domain repeats. The size of the apo(a) isoform is inversely proportional to the blood concentration of Lp(a). Lp(a) is a strong and independent cardiovascular risk factor. Elevated Lp(a) levels ≥ 50 mg/dl (≥ 125 nmol/l) are estimated to occur in more than 1...
2024: Archives of Medical Science: AMS