Jingteng Chen, Ling Yu, Tian Gao, Xiangyang Dong, Shiyu Li, Yinchu Liu, Jian Yang, Kezhou Xia, Yaru Yu, Yingshuo Li, Sen Wang, ZhengFu Fan, Hongbing Deng, Weichun Guo
Magnesium phosphate bone cements (MPC) have been recognized as a viable alternative for bone defect repair due to their high mechanical strength and biodegradability. However, their poor porosity and permeability limit osteogenic cell ingrowth and vascularization, which is critical for bone regeneration. In the current study, we constructed a novel hierarchically-porous magnesium phosphate bone cement by incorporating extracellular matrix (ECM)-mimicking electrospun silk fibroin (SF) nanofibers. The SF-embedded MPC (SM) exhibited a heterogeneous and hierarchical structure, which effectively facilitated the rapid infiltration of oxygen and nutrients as well as cell ingrowth...
July 2024: Bioactive Materials