Marc d'Elbée, Martin Harker, Nyashadzaishe Mafirakureva, Mastula Nanfuka, Minh Huyen Ton Nu Nguyet, Jean-Voisin Taguebue, Raoul Moh, Celso Khosa, Ayeshatu Mustapha, Juliet Mwanga-Amumpere, Laurence Borand, Sylvie Kwedi Nolna, Eric Komena, Saniata Cumbe, Jacob Mugisha, Naome Natukunda, Tan Eang Mao, Jérôme Wittwer, Antoine Bénard, Tanguy Bernard, Hojoon Sohn, Maryline Bonnet, Eric Wobudeya, Olivier Marcy, Peter J Dodd
BACKGROUND: The burden of childhood tuberculosis remains high globally, largely due to under-diagnosis. Decentralising childhood tuberculosis diagnosis services to lower health system levels could improve case detection, but there is little empirically based evidence on cost-effectiveness or budget impact. METHODS: In this mathematical modelling study, we assessed the cost-effectiveness and budget impact of decentralising a comprehensive diagnosis package for childhood tuberculosis to district hospitals (DH-focused) or primary health centres (PHC-focused) compared to standard of care (SOC)...
April 2024: EClinicalMedicine