Muhammet Oner, Mei-Chih Chen, Pang-Ting Cheng, Yu-Hsuan Li, Yu-Chiao Cheng, Ayse Celik, Shiuan-Woei Soong, Li-Wen Hsu, Din-You Lin, G M Shazzad Hossain Prince, Trayee Dhar, Hsu-Chen Cheng, Pin-Chi Tang, Ho Lin
Metformin, the most commonly prescribed drug for the treatment of diabetes, is increasingly used during pregnancy to address various disorders such as diabetes, obesity, preeclampsia, and metabolic diseases. However, its impact on neocortex development remains unclear. Here, we investigated the direct effects of metformin on neocortex development, focusing on ERK and p35/CDK5 regulation. Using a pregnant rat model, we found that metformin treatment during pregnancy induces small for gestational age (SGA) and reduces relative cortical thickness in embryos and neonates...
April 25, 2024: Chemosphere