Yicheng Ye, Hao Tian, Jiamiao Jiang, Weichang Huang, Ruotian Zhang, Huaan Li, Lu Liu, Junbin Gao, Haixin Tan, Meihuan Liu, Fei Peng, Yingfeng Tu
An efficient and cost-effective therapeutic vaccine is highly desirable for the prevention and treatment of cancer, which helps to strengthen the immune system and activate the T cell immune response. However, initiating such an adaptive immune response efficiently remains challenging, especially the deficient antigen presentation by dendritic cells (DCs) in the immunosuppressive tumor microenvironment. Herein, an efficient and dynamic antigen delivery system based on the magnetically actuated OVA-CaCO3 -SPIO robots (OCS-robots) is rationally designed for active immunotherapy...
June 29, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)