Marcelly C S R Pitombeira, Policarpo A S Júnior, Silvane Maria Fonseca Murta, Alvaro Romanha, Pedro H Luccas, M Cristina Nonato, Rafael E O Rocha, Rafaela S Ferreira, Flávia F da Silveira, Frederico S Castelo-Branco, Alcione S Carvalho, Nubia Boechat
Chagas disease is a neglected tropical parasitic disease caused by the protozoan Trypanosoma cruzi. Worldwide, an estimated 8 million people are infected with T. cruzi, causing more than 10,000 deaths per year. Currently, only two drugs, nifurtimox and benznidazole (BNZ), are approved for its treatment. However, both are ineffective during the chronic phase, show toxicity, and produce serious side effects. This work aimed to obtain and evaluate novel 2-nitroimidazole-N-acylhydrazone derivatives analogous to BNZ...
April 16, 2024: Archiv der Pharmazie