keyword
https://read.qxmd.com/read/38702783/trauma-exposure-across-the-lifespan-among-individuals-engaged-in-treatment-with-medication-for-opioid-use-disorder-differences-by-gender-ptsd-status-and-chronic-pain
#1
RANDOMIZED CONTROLLED TRIAL
Monique N Rodríguez, Dana D Colgan, Sarah Leyde, Kenneth Pike, Joseph O Merrill, Cynthia J Price
BACKGROUND: There is little study of lifetime trauma exposure among individuals engaged in medication treatment for opioid use disorder (MOUD). A multisite study provided the opportunity to examine the prevalence of lifetime trauma and differences by gender, PTSD status, and chronic pain. METHODS: A cross-sectional study examined baseline data from participants (N = 303) enrolled in a randomized controlled trial of a mind-body intervention as an adjunct to MOUD...
May 3, 2024: Substance Abuse Treatment, Prevention, and Policy
https://read.qxmd.com/read/38702447/the-influence-of-drying-and-storage-conditions-on-the-volatilome-and-cannabinoid-content-of-cannabis-sativa-l-inflorescences
#2
JOURNAL ARTICLE
Natasha Damiana Spadafora, Simona Felletti, Tatiana Chenet, Tiziana Maria Sirangelo, Mirco Cescon, Martina Catani, Chiara De Luca, Claudia Stevanin, Alberto Cavazzini, Luisa Pasti
The increasing interest in hemp and cannabis poses new questions about the influence of drying and storage conditions on the overall aroma and cannabinoids profile of these products. Cannabis inflorescences are subjected to drying shortly after harvest and then to storage in different containers. These steps may cause a process of rapid deterioration with consequent changes in precious secondary metabolite content, negatively impacting on the product quality and potency. In this context, in this work, the investigation of the effects of freeze vs tray drying and three storage conditions on the preservation of cannabis compounds has been performed...
May 3, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38702140/mapping-health-technology-assessment-agency-approaches-for-biosimilar-value-assessment-an-ispor-special-interest-group-report
#3
JOURNAL ARTICLE
Teresa Barcina Lacosta, András Inotai, Catarina Lopes Pereira, Liese Barbier, Steven Simoens
OBJECTIVES: A systematic literature review undertaken by the ISPOR Biosimilar Special Interest Group highlighted that limited guidance exists on how to assess biosimilars value and on appropriate economic evaluation techniques. This study described current health technology assessment (HTA) agency approaches for biosimilar value assessment. METHODS: Semi-structured interviews (n = 16) were carried out with HTA experts in Africa, America, Asia, Australia, and Europe to investigate current HTA practices for biosimilars...
May 2024: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://read.qxmd.com/read/38701779/identification-of-unapproved-orthopedic-regenerative-medicine-usefulness-of-the-act-on-safety-of-regenerative-medicine
#4
JOURNAL ARTICLE
Yuichiro Ukon, Satoshi Hosoya, Kazuki Morita, Yuji Yokozeki, Tomoko Kataoka, Takayuki Kitahara, Hirokazu Mae, Yuya Kanie, Masayuki Furuya, Takahito Fujimori, Takashi Kaito, Kiyoshi Okada, Akira Myoui, Seiji Okada
In Japan, the Act on Safety of Regenerative Medicine regulates unapproved regenerative medicine. Other nations market regenerative medicine products, bypassing regulatory approval. To identify unapproved orthopedic regenerative medicine, we have used data based on the Act. Platelet-rich plasma was often used. The common target was the knee. Prices averaged $2,490.
April 26, 2024: Stem Cell Reports
https://read.qxmd.com/read/38701495/exploring-definitions-and-predictors-of-severe-asthma-clinical-remission-post-biologic-in-adults
#5
JOURNAL ARTICLE
Luis Perez-de-Llano, Ghislaine Scelo, Trung N Tran, Tham T Le, Malin Faregås, Borja G Cosio, Matthew Peters, Paul E Pfeffer, Mona Al-Ahmad, Riyad O Al-Lehebi, Alan Altraja, Celine Bergeron, Leif H Bjermer, Anne S Bjerrum, Lakmini Bulathsinhala, John Busby, Diana J Cano Rosales, Giorgio W Canonica, Victoria A Carter, Jeremy Charriot, George C Christoff, Eve J Denton, Delbert R Dorscheid, Maria J Fernandez Sanchez, João A Fonseca, Peter G Gibson, Celine Y Y Goh, Liam G Heaney, Enrico Heffler, Mark Hew, Takashi Iwanaga, Rohit Katial, Mariko S Koh, Piotr Kuna, Désirée E S Larenas-Linnemann, Lauri Lehtimäki, Bassam Mahboub, Neil Martin, Hisako Matsumoto, Andrew N Menzies-Gow, Nikolaos G Papadopoulos, Todor A Popov, Celeste M Porsbjerg, Pujan Patel, Chin K Rhee, Mohsen Sadatsafavi, Camille Taillé, Carlos A Torres-Duque, Ming-Ju Tsai, Charlotte S Ulrik, John W Upham, Anna von Bülow, Eileen Wang, Michael E Wechsler, David B Price
RATIONALE: There is no consensus on criteria to include in an asthma remission definition in real-life. Factors associated with achieving remission post-biologic-initiation remain poorly understood. OBJECTIVES: To quantify the proportion of adults with severe asthma achieving multi-domain-defined remission post-biologic-initiation and identify pre-biologic characteristics associated with achieving remission which may be used to predict it. METHODS: This was a longitudinal cohort study using data from 23 countries from the International Severe Asthma Registry...
May 3, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38701029/financial-impact-of-integrated-specialty-pharmacy-efforts-to-avoid-oral-anticancer-medication-waste
#6
JOURNAL ARTICLE
Brooke Looney, Jared Crumb, Stephanie White, Gabrielle Jones, Ryan P Moore, Leena Choi, Autumn D Zuckerman, Kristen Whelchel
BACKGROUND: The growing number of oral anticancer medications represents a significant portion of pharmacy spending and can be costly for patients. Patients taking oral anticancer medications may experience frequent treatment changes following necessary safety and effectiveness monitoring, often resulting in medication waste. Strategies to avoid medication waste could alleviate the financial burden of these costly therapies on the payer and the patient. OBJECTIVE: To evaluate the impact on waste and cost avoidance of reviewing the amount of medication patients have on hand and the presence of upcoming follow-up (ie, provider visit, laboratory testing, or imaging) before requesting a prescription refill renewal for patients taking oral anticancer medications through an integrated health system specialty pharmacy...
May 2024: Journal of Managed Care & Specialty Pharmacy
https://read.qxmd.com/read/38701027/health-care-decision-maker-perceptions-and-trends-in-the-utilization-of-preapproval-information-for-formulary-decision-making
#7
JOURNAL ARTICLE
Tamara Brisibe, Zade Hikmat, Tasmina Hydery, Claire Gorey, Kimberly Boswell
BACKGROUND: Preapproval information exchange (PIE) has increased between biopharma companies and health care decision-makers (HCDMs) over the last several years. However, there still exists a gap in what HCDMs need and what biopharma companies are providing. OBJECTIVE: To assess trends in the utilization of preapproval information by HCDMs and identify resources that may best support organizations in evaluating product information for formulary coverage prior to US Food and Drug Administration approval...
May 2024: Journal of Managed Care & Specialty Pharmacy
https://read.qxmd.com/read/38700853/us-hospital-service-availability-and-new-340b-program-participation
#8
JOURNAL ARTICLE
Kelsey M Owsley, Romana Hasnain-Wynia, Ronica N Rooks, Gregory J Tung, Glen P Mays, Richard C Lindrooth
IMPORTANCE: The US 340B Drug Pricing Program enables eligible hospitals to receive substantial discounts on outpatient drugs to improve hospitals' financial sustainability and maintain access to care for patients who have low income and/or are uninsured. However, it is unclear whether hospitals use program savings to subsidize access as intended. OBJECTIVE: To evaluate whether the 340B program is associated with improvements in access to hospital-based services and to test whether the association varies by hospital ownership...
May 3, 2024: JAMA health forum
https://read.qxmd.com/read/38700234/evaluating-unmet-needs-in-large-volume-subcutaneous-drug-delivery-u-s-payer-perspectives-on-a-novel-large-volume-on-body-delivery-system
#9
REVIEW
Mehul Desai, James Kenney, Edmund Pezalla
Existing healthcare systems face finite resource allocation and budgetary constraints, resulting in a substantial need for innovative solutions to enhance service delivery at reduced costs. A novel, user-friendly on-body delivery system (OBDS) was developed which enables administration of large-volume subcutaneous (SC) drugs in both clinical and home-based settings (at-home HCP administration or at-home self-administration). This research sought to evaluate the potential economic impact of at-home self- or HCP- administration with the OBDS through a comprehensive review of published literature and semi-structured interviews with 17 US payers representing approximately 227 million covered lives...
May 3, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38699730/optimizing-hybrid-energy-systems-for-remote-communities-in-asia-s-least-developed-countries
#10
JOURNAL ARTICLE
Mengly Prum, Hui Hwang Goh, Dongdong Zhang, Wei Dai, Tonni Agustiono Kurniawan, Kai Chen Goh
In least-developed countries (LDCs), electricity shortages are the primary barrier to economic and social growth. Some remote areas in LDC rely on diesel-based systems. However, renewable energy must be taken into account for generating electricity because of the uncertainty of diesel fuel prices and the emissions of carbon dioxide. Hybrid energy systems (HES) are becoming increasingly popular, which is unsurprising given the rapid advancement of renewable energy technologies, which have made them the preferred method to respond to the current unreliable electricity supply, reduce the impact of global warming that occurs from electricity production, and contribute to cost reduction...
April 30, 2024: Heliyon
https://read.qxmd.com/read/38699729/green-supply-chain-finance-strategies-with-market-competition-and-financial-constraints
#11
JOURNAL ARTICLE
Jing Huang, He Huang, Yinyuan Si, Yuanfei Xu, Sen Liu, Xuejian Yang
In the context of sustainable development, market competition is intensifying, and financial constraints have emerged as a significant hindrance to green project investment. Green Supply Chain Finance (GSCF), characterized by long-term collaboration, has emerged as a crucial financial approach to mitigate corporate financial limitations and channel capital flows into environmentally friendly industries. We propose a two-echelon supply chain with one supplier and two competing retailers over a single period and investigate ordering, sales, and financing decisions simultaneously under competition...
April 30, 2024: Heliyon
https://read.qxmd.com/read/38699224/the-price-of-hope-car-t-therapy-in-pediatric-leukemia
#12
EDITORIAL
Alex Hoover
No abstract text is available yet for this article.
2024: Oncoscience
https://read.qxmd.com/read/38699081/-i-like-the-vibes-it-gives-adolescent-perspectives-on-cannabis-billboards-and-print-advertising-in-nevada
#13
JOURNAL ARTICLE
Cara S Drake, Kim Sloan, Meghan Anderson, Kristen D Clements-Nolle, Jennifer L Pearson
An influx of laws permitting recreational cannabis sales in the US has allowed for increased advertising. The purpose of this study was to describe how adolescents perceive outdoor and print cannabis advertising and to identify aspects of advertising that are appealing or eye-catching, focusing on five themes: price promotion, sex appeal, wellness, party, and text-only. We recruited adolescents ages 11-17 to participate in seven focus groups (44 participants) from 2019 to 2020. Participants viewed cannabis advertisements and responses were summarized using deductive thematic analysis...
April 2024: Journal of Drug Issues
https://read.qxmd.com/read/38699040/investigating-the-role-of-nuclear-power-and-battery-storage-in-hungary-s-energy-transition-using-hourly-resolution-electricity-market-simulations
#14
JOURNAL ARTICLE
Bence Biró, Attila Aszódi
Electricity supply in European countries faces a number of challenges, such as achieving carbon neutrality, tackling rising prices, reducing dependence on fossil fuels, including fossil fuel imports. To achieve these goals, the electricity systems of all European countries will have to undergo major changes, while taking into account technical, environmental, economic and social objectives. Our simulations provide essential data for this transition by analyzing different power plant portfolios and electricity consumption scenarios...
May 15, 2024: Heliyon
https://read.qxmd.com/read/38699026/beef-cattle-fattening-practices-marketing-systems-and-challenges-the-case-of-bench-sheko-and-sheka-zones-of-southwest-ethiopia
#15
JOURNAL ARTICLE
Matawork Milikias, Mitiku Gebre
This study was conducted to assess beef cattle fattening practices, marketing systems, and challenges in the Bench Sheko and Sheka zones of South West Ethiopia. Multi-stage purposive and random sampling procedures were used. A total of 384 households were selected randomly and interviewed using a structured questionnaire. Secondary data were collected from zones and district offices. The collected data were managed and analyzed using SPSS version 20. Statistical differences were declared at P < 0...
May 15, 2024: Heliyon
https://read.qxmd.com/read/38698978/residual-energy-use-and-energy-efficiency-improvement-of-european-supermarket-facilities-during-the-post-covid-and-energy-crisis-period
#16
JOURNAL ARTICLE
Juan Carlos Ríos-Fernández, Juan Manuel González-Caballín, Andrés Meana-Fernández, Antonio José Gutiérrez-Trashorras
Supermarkets are significant consumers of electricity and contribute to the generation of associated pollutant emissions. This will help to mitigate the impact of increased energy costs on the prices of products sold in supermarkets. Therefore, it is essential to reduce energy consumption, starting with the equipment that consumes the most electricity, such as refrigeration, and using the residual thermal energy generated in supermarkets. This paper discusses the impact of rising energy costs in the post-Covid era and during the energy crisis...
May 15, 2024: Heliyon
https://read.qxmd.com/read/38698972/integrated-assessment-of-irrigation-and-agriculture-management-challenges-in-nepal-an-interdisciplinary-perspective
#17
JOURNAL ARTICLE
Santosh Nepal, Nilhari Neupane, Sanju Koirala, Jonathan Lautze, Ram Narayan Shrestha, Dinesh Bhatt, Nirman Shrestha, Manju Adhikari, Santosh Kaini, Shanta Karki, Jigyasha Rai Yangkhurung, Kapil Gnawali, Ananta Man Singh Pradhan, Krishna Timsina, Saurav Pradhananga, Manohara Khadka
Agriculture plays a critical role in ensuring food and nutrition security, livelihood, and rural employment in Nepal. Despite substantial investments and institutional reforms, irrigation projects have faced consistently low performance. While existing studies have shed light on technical aspects of irrigation performance, they often focus on specific themes rather than holistic evaluations of sustainability. This research systematically assesses barriers and challenges to effective irrigation water management in Nepal by assessing and ranking the challenges faced by three irrigation systems in western Nepal: Mahakali, Rani Jamara Kulariya, and Babai...
May 15, 2024: Heliyon
https://read.qxmd.com/read/38698923/lactic-acid-fermentation-of-food-waste-at-acidic-conditions-in-a-semicontinuous-system-effect-of-hrt-and-olr-changes
#18
JOURNAL ARTICLE
Simone Pau, Lea Chua Tan, Sonia Arriaga, Piet N L Lens
Lactic acid production through fermentation is an established technology, however, improvements are necessary to reduce the process costs and to decrease its market price. Lactic acid is used in many industrial sectors and its market has increased in the last decade for its use as the raw material for polylactic acid product. Using food waste as a cheap and renewable substrate, as well as fermentation at uncontrolled pH, helps to make the production cheaper and to simplify the downstream purification process...
2024: Biomass Conversion and Biorefinery
https://read.qxmd.com/read/38698894/combination-of-antistaphylococcal-%C3%AE-lactam-with-standard-therapy-compared-to-standard-therapy-alone-for-the-treatment-of-methicillin-resistant-staphylococcus-aureus-bacteremia-a-post-hoc-analysis-of-the-camera2-trial-using-a-desirability-of-outcome-ranking
#19
JOURNAL ARTICLE
Neta Petersiel, Joshua S Davis, Niamh Meagher, David J Price, Steven Y C Tong
BACKGROUND: Desirability of outcome ranking (DOOR) is an emerging approach to clinical trial outcome measurement using an ordinal scale to incorporate efficacy and safety endpoints. METHODS: We applied a previously validated DOOR endpoint to a cohort of CAMERA2 trial participants with methicillin-resistant Staphylococcus aureus bacteremia (MRSAB). Participants were randomly assigned to standard therapy, or to standard therapy plus an antistaphylococcal β-lactam (combination therapy)...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38698831/willingness-to-pay-for-health-apps-its-sociodemographic-correlates-and-reasons-for-being-unwilling-to-pay
#20
JOURNAL ARTICLE
Hao Liu, Zhenzhen Xie, Calvin Or
BACKGROUND: Knowledge about whether, how much, and why individuals are willing to pay for health apps is limited. OBJECTIVES: This study aimed to examine (1) the proportion of individuals willing to pay for health apps, (2) their willingness to pay (WTP; i.e. the maximum price the individual is willing to pay) for health apps, (3) the sociodemographic correlates determining whether individuals are willing to pay for these apps, (4) the sociodemographic correlates of their WTP, and (5) reasons for being unwilling to pay...
2024: Digital Health
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