Padma P Nanaware, Zohaib N Khan, Cristina C Clement, Madhur Shetty, Ines Mota, Ethan S Seltzer, Monika Dzieciatkowska, Fabia Gamboni, Angelo D'Alessandro, Charles Ng, Manabu Nagayama, Cheryl F Lichti, Rajesh K Soni, Jacob B Geri, Irina Matei, David Lyden, Randy Longman, Theresa T Lu, Xiaoxiao Wan, Emil R Unanue, Lawrence J Stern, Laura Santambrogio
The lymphatic fluid is the conduit by which part of the tissue "omics" is transported to the draining lymph node for immunosurveillance. Following cannulation of the pre-nodal cervical and mesenteric afferent lymphatics, herein we investigate the lymph proteomic composition, uncovering that its composition varies according to the tissue of origin. Tissue specificity is also reflected in the dendritic cell-major histocompatibility complex class II-eluted immunopeptidome harvested from the cervical and mesenteric nodes...
June 5, 2024: Cell Reports