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JOURNAL ARTICLE
Fabian Wagenaars, Peter Cenijn, Zhongli Chen, Marcel Meima, Martin Scholze, Timo Hamers
Early brain development depends on adequate transport of thyroid hormones (THs) from the maternal circulation to the fetus. To reach the fetal brain, THs have to cross several physiological barriers, including the placenta, blood-brain-barrier and blood-cerebrospinal fluid-barrier. Transport across these barriers is facilitated by thyroid hormone transmembrane transporters (THTMTs). Some endocrine disrupting chemicals (EDCs) can interfere with the transport of THs by THTMTs. To screen chemicals for their capacity to disrupt THTMT facilitated TH transport, in vitro screening assays are required...
May 18, 2024: Archives of Toxicology
#2
JOURNAL ARTICLE
Sarah Cho, Sheryl L Rifas-Shiman, Soren Harnois-Leblanc, Izzuddin M Aris, Emily Oken, Marie-France Hivert
OBJECTIVE: To examine the associations of abnormal maternal glucose regulation in pregnancy with offspring adiposity, insulin resistance, adipokine, and inflammatory markers during childhood and adolescence. STUDY DESIGN: Project Viva is a prospective pre-birth cohort (n = 2,128 live births) initiated from 1999 through 2002 in Eastern Massachusetts, US. During the second trimester of pregnancy, clinicians used two-step oral glucose challenge testing to screen for gestational diabetes mellitus (GDM)...
May 15, 2024: Journal of Pediatrics
#3
JOURNAL ARTICLE
Sophie Dreux, Jonathan Rosenblatt, Jérôme Massardier, Alexandra Benachi, Etienne Voirin-Mathieu, Françoise Muller
AIM: This aim of this study was to detail maternal and fetal anomalies observed on a national scale in a large French cohort of patients presenting high hCG values (≥10 multiple of the median [MoM]) at Down syndrome screening in order to define clear and optimal guidelines. METHODS: This is a retrospective multicenter study based on a French annual database of all trisomy 21 screenings. Our study targeted and studied cases with hCG or hCGβ values ≥10 MoM...
May 17, 2024: Prenatal Diagnosis
#4
JOURNAL ARTICLE
Federico Salas-Lucia
BACKGROUND: Normal brain development, mood, and cognitive functions depend on thyroid hormone (TH) action. However, little is known about how TH mediates its actions in the human brain. This is because of limited access to human brains deprived of TH during fetal and early postnatal life, as well as from adults with altered thyroid status. One way to partially bypass these limitations is by using magnetic resonance imaging and spectroscopy, two neuroimaging techniques that provide detailed, non-invasive information on human brain structure and function...
May 17, 2024: Thyroid: Official Journal of the American Thyroid Association
#5
JOURNAL ARTICLE
Can Peng, LanPing Hu, XiuFen Bu, HongYu Li, XuanYu Jiang, ShiHao Zhou, Li Deng, Jun He, SiYuan LinPeng
To determine the detection rate of chromosomal abnormalities and pregnancy outcomes in fetuses with intrauterine growth restriction. Study design A total of 151 fetal samples with intrauterine growth restriction were divided into the isolated fetal growth restriction (FGR) group, FGR group with structural malformation, and FGR group with non-structural malformation, according to ultrasound abnormalities. The enrolled patients were divided into an early onset FGR group (<32 weeks) and a late-onset FGR group (≥32 weeks)...
May 11, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
#6
JOURNAL ARTICLE
Sedigheh Hantoushzadeh, Omid Kohandel Gargari, Marzieh Jamali, Fatemeh Farrokh, Nasim Eshraghi, Fatemeh Asadi, Masoumeh Mirzamoradi, Seyed Jafar Razavi, Marjan Ghaemi, Sudabeh Kazemi Aski, Zahra Panhi, Gholam Reza Habibi
BACKGROUND: Fetal movement monitoring is one of the strategies used to assess the fetus's health. Until now, most studies focused on the decreased fetal movement and neonatal outcome, although this systematic review and meta-analysis is designed to assess the association between increased fetal movements (IFM) with perinatal outcomes. METHOD: The electronic databases including PubMed, Scopus, Web of Science, and EMBASE were systematically searched for studies investigating the perinatal outcome of women with increased fetal movements from inception to July 2023...
May 15, 2024: BMC Pregnancy and Childbirth
#7
JOURNAL ARTICLE
Guoyu Du, Cheng Zhang, Xiaoan Cao, Lingxia Li, Yong Zhang, Youjun Shang, Jinyan Wu
BACKGROUND: Primary sheep fetal fibroblasts (SFFCs) have emerged as a valuable resource for investigating the molecular and pathogenic mechanisms of orf viruses (ORFV). However, their utilization is considerably restricted due to the exorbitant expenses associated with their isolation and culture, their abbreviated lifespan, and the laborious procedure. RESULTS: In our investigation, the primary SFFCs were obtained and immortalized by introducing a lentiviral recombinant plasmid containing the large T antigen from simian virus 40 (SV40)...
May 14, 2024: BMC Veterinary Research
#8
JOURNAL ARTICLE
Giovanni Nazzaro, Gabriele Saccone, Marilena Miranda, Alessandra Ammendola, Giorgia Buonomo, Daniele Neola, Giorgia Bartolini, Mariavittoria Locci
OBJECTIVE: To evaluate the prediction performance of E-Cervix™ for preterm birth in twin pregnancies with threatened preterm labor. METHODS: This was a single-center retrospective cohort study of twin pregnancies presenting to obstetrics triage for threatened preterm labor (PTL) between 23 0/7 - 33 6/7 weeks who received screening for PTL with transvaginal ultrasound cervical length (TVU CL) and cervical elastography with E-Cervix™ at the time of triage...
May 6, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
#9
REVIEW
Frederik B Clausen
In pregnancy, D- pregnant women may be at risk of becoming immunized against D when carrying a D+ fetus, which may eventually lead to hemolytic disease of the fetus and newborn. Administrating antenatal and postnatal anti-D immunoglobulin prophylaxis decreases the risk of immunization substantially. Noninvasive fetal RHD genotyping, based on testing cell-free DNA extracted from maternal plasma, offers a reliable tool to predict the fetal RhD phenotype during pregnancy. Used as a screening program, antenatal RHD screening can guide the administration of antenatal prophylaxis in non-immunized D- pregnant women so that unnecessary prophylaxis is avoided in those women who carry a D- fetus...
April 1, 2024: Immunohematology
#10
JOURNAL ARTICLE
Marie Elisabeth Helmbæk, Karin Sundberg, Ditte Staub Jørgensen, Olav Bjørn Petersen, Martin Tolsgaard, Niels Grove Vejlstrup, Lotte Harmsen, Charlotte Kruse, Jesper Steensberg, Cathrine Vedel, Charlotte Kvist Ekelund
OBJECTIVE: To examine the feasibility and performance of implementing a standardized fetal cardiac scan at the time of a routine first-trimester ultrasound scan. METHOD: A retrospective, single-center study in an unselected population between March 2021 and July 2022. A standardized cardiac scan protocol consisting of a four-chamber and 3-vessel trachea view with color Doppler was implemented as part of the routine first-trimester scan. Sonographers were asked to categorize the fetal heart anatomy...
May 13, 2024: Prenatal Diagnosis
#11
Ruizheng Han, Chunshuang Zhang, Xiling Fu, Zhengfeng Zhu, Xinxia Wang, Hezhou Li
INTRODUCTION: Cleidocranial dysplasia (CCD) is a rare autosomal dominant skeletal dysplasia that presents with abnormalities in the craniofacial region, teeth, and clavicles and is linked to RUNX2 mutation. Prenatal diagnoses of CCD have rarely been reported, and most of these cases have a positive family history. Here we report two prenatally diagnosed CCD cases without a positive family history. We conducted a literature review to summarize the prenatal sonographic findings of CCD. CASE REPORTS: Case 1 (a 26-year-old woman): ultrasound at 13 weeks showed a thickened nuchal translucency with absent nasal bones and poor ossifications in the cranium and vertebrae...
May 15, 2024: Heliyon
#12
JOURNAL ARTICLE
Robyn McCarthy, Carolyn Blackburn, Raja As Mukherjee, Clare S Allely, Penny A Cook
BACKGROUND: Screening children for developmental disorders presents unique ethical and methodological challenges, particularly with disorders associated with high levels of shame and stigma. Fetal alcohol spectrum disorder (FASD) is a neurodevelopmental condition resulting from prenatal alcohol exposure. The potential distress caused by informing parents that their child may have FASD has been cited as a significant barrier to conducting such studies. However, limited research has investigated the impact of screening for FASD on parents and children...
May 15, 2024: Heliyon
#13
Joanna J Kim, Katherine Bonhomme, Lawrence W Oppenheimer, Laura Gaudet
Vasa previa occurs when fetal vessels lie above the cervical os. A novel type of vasa previa, known as type III, is characterized by an abnormal branching of fetal vessels from the placenta in the absence of velamentous cord insertion (as seen in type I) or multilobed placenta (as seen in type II). Here, we present a case of a type III vasa previa after a resolution of a low-lying placenta. The presence of any known risk factors of vasa previa, including low-lying placenta, should prompt screening for vasa previa in the third trimester...
April 2024: American Journal of Perinatology Reports
#14
REVIEW
Laura M Card, Alexandra V Klinkowski, Elijah Salzer, Eric C Nemec Ii, Suzanne J Rose
OBJECTIVE: Postpartum hemorrhage is a leading cause of maternal mortality and morbidity around the globe. The novel low-suction vacuum hemorrhage device (VHD) provides an alternative treatment option for cases of postpartum hemorrhage when first-line uterotonic agents fail. This systematic review aims to review current data evaluating the overall efficacy and safety of VHDs in treating postpartum hemorrhage. METHODS: We searched CINAHL Ultimate, Academic Search Premier, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, MEDLINE with Full Text, and PubMed and reference lists of retrieved studies for eligible studies that included outcomes of effectiveness, efficacy, or safety...
December 2024: Journal of Maternal-fetal & Neonatal Medicine
#15
JOURNAL ARTICLE
Alexandra Queirós, Laura Gomes, Inês Pereira, Nádia Charepe, Marta Plancha, Sofia Rodrigues, Álvaro Cohen, Marta Alves, Ana Luísa Papoila, Teresinha Simões
PURPOSE: This study aimed to determine the association of first-trimester maternal serum biomarkers with preterm birth (PTB), fetal growth restriction (FGR) and hypertensive disorders of pregnancy (HDP) in twin pregnancies. METHODS: This is a retrospective cohort study of twin pregnancies followed at Maternidade Dr. Alfredo da Costa, Lisbon, Portugal, between January 2010 and December 2022. We included women who completed first-trimester screening in our unit and had ongoing pregnancies with two live fetuses, and delivered after 24 weeks...
May 12, 2024: Archives of Gynecology and Obstetrics
#16
JOURNAL ARTICLE
Reema Garegrat, Atul Londhe, Swati Manerkar, Sudhindrashayana Fattepur, Laxmikant Deshmukh, Amol Joshi, Savitha Chandriah, Mallesh Kariyappa, Sahana Devadas, Theranirajan Ethirajan, Kalaivani Srivasan, Chinnathambi Kamalarathnam, Anitha Balachandran, Elango Krishnan, Deepthy Sahayaraj, Prathik Bandiya, Niranjan Shivanna, Constance Burgod, Ashwini Thayyil, Annie Alocious, Marianna Lanza, Pallavi Muraleedharan, Stuti Pant, Harini Venkateswaran, Maria Moreno Morales, Paolo Montaldo, Vaisakh Krishnan, Thaslima Kalathingal, Anagha Rajeev Joshi, Ajay Vare, G C Patil, Babu Peter Satyanathan, Pavan Hapat, Abhishek Deshmukh, Indramma Shivarudhrappa, Manjesh Kurupalya Annayappa, Mythili Baburaj, Christina Muradi, Esprance Fernandes, Nishad Thale, Ismat Jahan, Mohammed Shahidullah, Sadeka Moni Choudhury, Sanjoy Kumer Dey, Sutapa B Neogi, Rupsa Banerjee, Vanessa Rameh, Farah Alobeidi, Ellen Grant, Sandra E Juul, Martin Wilson, Enrico De Vita, Ronit Pressler, Paul Bassett, Seetha Shankaran, Sudhin Thayyil
OBJECTIVE: To examine the feasibility of early and extended erythropoietin monotherapy after hypoxic ischaemic encephalopathy (HIE). DESIGN: Double-blind pilot randomised controlled trial. SETTING: Eight neonatal units in South Asia. PATIENTS: Neonates (≥36 weeks) with moderate or severe HIE admitted between 31 December 2022 and 3 May 2023. INTERVENTIONS: Erythropoietin (500 U/kg daily) or to the placebo (sham injections using a screen) within 6 hours of birth and continued for 9 days...
May 10, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
#17
JOURNAL ARTICLE
Eric Jauniaux, Cathrine Ebbing, Yinka Oyelese, Rony Maymon, Federico Prefumo, Amar Bhide
Congenital anomalies of the umbilical cord are associated with an increased risk of pregnancy and perinatal complications. Some anomalies of the cord have a higher prevalence than other fetal structural anomalies. The most common anomalies are the absence of an umbilical artery and velamentous insertion of the cord (with or without vasa previa). These anomalies, even when not associated with fetal structural defects, increase the risk of adverse perinatal outcome including, fetal growth restriction and stillbirth...
April 30, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
#18
JOURNAL ARTICLE
Gerd A Blobel, Eugene Khandros
It has been known for over half a century that humans produce different forms of hemoglobin, a tetramer of α- and β-like hemoglobin chains, throughout ontogeny. The switch from fetal to adult hemoglobin occurs around the time of birth when erythropoiesis shifts from the fetal liver to the bone marrow. Naturally, diseases caused by defective adult β-globin genes, such as sickle cell disease and β-thalassemia manifest themselves as production of fetal hemoglobin fades. Reversal of this developmental switch has been a major goal to treat these diseases and has been a driving force to understand its underlying molecular biology...
May 10, 2024: Blood
#19
JOURNAL ARTICLE
Nan Ma, Jian Zhang, Jinming Kong, Xueji Zhang
Accurate and quantitative detection of pre-eclampsia markers is crucial in reducing pregnancy mortality rates. This study introduces a novel approach utilizing a fluorescent biosensor by the immunosorbent atom transfer radical polymerization (immuno-ATRP) assay to detect the pre-eclampsia protein marker CD81. The critical step used in this sensor is the novel signal amplification strategy of fluorescein polymerization mediated by ferritin-enhanced controlled radical polymerization, which combines with a traditional enzyme-linked immunosorbent assay (ELISA) to further reduce the detection limit of the CD81 protein concentration...
May 10, 2024: Analytical Chemistry
#20
JOURNAL ARTICLE
Bryann Bromley, Lawrence D Platt
Technologic advances and ultrasonographer-physician experience in fetal imaging have led to significant improvements in our ability to distinguish between normal and abnormal fetal structural development in the latter part of the first trimester. As a critical component of pregnancy care, assessment of fetal anatomy at the end of the first trimester with a standardized imaging protocol should be offered to all pregnant patients regardless of aneuploidy screening results because it has been demonstrated to identify approximately half of fetal structural malformations...
May 9, 2024: Obstetrics and Gynecology
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