Elżbieta Krzesiek, Ewa Nienartowicz, Barbara Iwańczak
PURPOSE: Crohn's disease (CD) is a chronic inflammatory disease which can affect all parts of the gastrointestinal tract. Magnetic resonance enterography (MRE) enables detection of pathologic changes in the small intestine, which are not accessible by conventional endoscopy. The aim of the study was to assess the value of MRE in imaging of small bowel lesions, their location and extent, in CD patients and its correlation with clinical and endoscopic activity. MATERIALS AND METHODS: MRE was performed in 108 children with CD, aged 5...
February 19, 2020: Advances in Medical Sciences
Seunghyun Lee, Young Hun Choi, Yeon Jin Cho, Jung-Eun Cheon, Jin Soo Moon, Gyeong Hoon Kang, Woo Sun Kim
OBJECTIVES: To evaluate the clinical usefulness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in children and young adults with Crohn's disease. METHODS: From August 2017 to October 2018, 30 patients with Crohn's disease (21 males and 9 females; mean age 15.1 ± 2.5 years) underwent DCE-MRI with MRI enterography. We assessed the endoscopic finding, pediatric Crohn's disease activity index (PCDAI), C-reactive protein (CRP) level (mg/dL), Crohn's disease MR index (CDMI) score, and the perfusion parameters of DCE-MRI (Ktrans , Kep , and Ve ) at the ileocecal region between the inactive and active groups based on the histopathologic status...
February 20, 2020: European Radiology
Kinga Kowalska-Duplaga, Tomasz Gosiewski, Przemysław Kapusta, Agnieszka Sroka-Oleksiak, Andrzej Wędrychowicz, Stanisław Pieczarkowski, Agnieszka H Ludwig-Słomczyńska, Paweł P Wołkow, Krzysztof Fyderek
The aetiology of inflammatory bowel diseases (IBD) seems to be strongly connected to changes in the enteral microbiome. The dysbiosis pattern seen in Crohn's disease (CD) differs among published studies depending on patients' age, disease phenotype and microbiome research methods. The aims was to investigate microbiome in treatment-naive paediatric patients to get an insight into its structure at the early stage of the disease in comparison to healthy. Stool samples were obtained from controls and newly diagnosed patients prior to any intervention...
December 11, 2019: Scientific Reports
Jamie Piercy, Jennifer Stinson, Peter C Church, Thomas D Walters, Karen Frost, Sara Ahola Kohut
OBJECTIVES: The aim of this prospective cross-sectional study was to examine perfectionism, disease self-management, and psychosocial outcomes in a sample of adolescents with inflammatory bowel disease (IBD). METHODS: Adolescent patients with IBD and caregivers were enrolled in the study. Patients completed the Child and Adolescent Perfectionism Scale, the Strengths and Difficulties Questionnaire (SDQ), and the TRANSITION-Q. Parents completed the Multidimensional Perfectionism Scale and the parent form of the SDQ...
December 6, 2019: Journal of Pediatric Gastroenterology and Nutrition
Mi Jin Kim, Yon Ho Choe
OBJECTIVE: To explore the potential roles of Dickkopf-1 (DKK-1) and b-catenin in Crohn disease, and to evaluate the effects of a tumor necrosis factor (TNF)-a inhibitor on Wnt signaling in patients with the disease. METHODS: We enrolled 21 patients who received infliximab treatment for one year and achieved clinical remission during the treatment period. Disease activity was graded according to the Pediatric Crohn's Disease Activity Index (PCDAI). Peripheral blood and colonic mucosal specimens were collected from all patients with Crohn disease and from 14 healthy controls...
November 15, 2019: Indian Pediatrics
Nadia Mazen Hijaz, Thomas Mario Attard, Jennifer Marie Colombo, Neil Joseph Mardis, Craig Alan Friesen
BACKGROUND: Magnetic resonance enterography (MRE) and wireless capsule endoscopy (WCE) are equally accepted modalities for noninvasive screening of small bowel involvement (SBI) in children with Crohn's disease (CD) and indeterminate colitis (IC) albeit there is a paucity of data comparing the two and thereby guiding the clinician in selecting the ideal diagnostic approach. Therefore, the goal of this study is to provide additional evidence for capsule endoscopy role in the evaluation of established Crohn's disease exacerbation compared to MRE in relation to Pediatric Crohn's Disease Activity Index (PCDAI), and histological indices...
July 28, 2019: World Journal of Gastroenterology: WJG
Arie Levine, Neil Chanchlani, Tomer Ziv-Baran, Johanna C Escher, Jorge Amil Dias, Gabor Veres, Sibylle Koletzko, Dan Turner, Kaija-Leena Kolho, Anders Paerregaard, Annamaria Staiano, Paolo Lionetti, Federica Nuti, Malgorata Sladek, Ron Shaoul, Isabella Lazowska-Prezeorek, Javier Martin de Carpi, Rotem Sigall Boneh, Tamar Pfeffer Gik, Noa Cohen-Dolev, Richard K Russell
INTRODUCTION: The ability to predict risk for poor outcomes in Crohn's disease (CD) would enable early treatment intensification. We aimed to identify children with CD with complications at baseline and throughout the study period who are at risk for surgery two years from diagnosis. MATERIAL AND METHODS: Newly diagnosed children with CD were enrolled into a prospective, multicentre inception cohort. Disease characteristics and serological markers were obtained at baseline and week 12 thereafter...
June 3, 2019: Journal of Crohn's & Colitis
Martinus A Cozijnsen, Assaf Ben Shoham, Ben Kang, Byung-Ho Choe, Yon Ho Choe, Maria Me Jongsma, Richard K Russell, Frank M Ruemmele, Johanna C Escher, Lissy de Ridder, Sibylle Koletzko, Javier Martín-de-Carpi, Jeffrey Hyams, Thomas Walters, Anne Griffiths, Dan Turner
BACKGROUND & AIMS: Mucosal healing (MH) has become a goal of therapy for Crohn's disease (CD), but frequent endoscopies are not feasible. We aimed to develop and validate a non-invasive index to assess mucosal inflammation in children with CD. METHODS: We collected data from the multi-center prospective ImageKids study, in which children with CD underwent ileocolonoscopy with magnetic resonance enterography. We investigated the association of pediatric CD activity index (PCDAI) items and laboratory test results with the simple endoscopic score for CD (SESCD)...
April 10, 2019: Clinical Gastroenterology and Hepatology
Angharad Vernon-Roberts, Robert N Lopez, Chris Frampton, Richard B Gearry, Daniel A Lemberg, Andrew S Day
OBJECTIVES: Clinical symptom evaluation for children with inflammatory bowel disease (IBD) is typically done using composite tools: the Pediatric Crohn's Disease Activity Index (PCDAI) and Pediatric Ulcerative Colitis Activity Index (PUCAI). Both rely on clinician interpretation of child or parent symptom recall. No universal self-report tool has yet been developed for children with IBD to assess and report their symptoms. The research objective was to develop a self-report tool that produced information congruent with that obtained by clinicians using the PUCAI or PCDAI...
March 26, 2019: Journal of Pediatric Gastroenterology and Nutrition
Anthony Mark Dalzell, Muhammad Eyad Ba'Ath
Inflammatory bowel disease (IBD) should be considered in any child with a persistently altered bowel habit. Growth failure may be a consequence and there may also be extra-intestinal manifestations. Oesophago-gastroduodenoscopy and colonoscopy and conventional histopathology are the diagnostic tools of choice in IBD. The identification and management of children with IBD in resource-poor settings is difficult and there are few data on its prevalence in low- and middle-income countries. The main challenges are a lack of resources and infrastructure including trained personnel in settings where there are other priorities for maintaining the health and wellbeing of children...
February 2019: Paediatrics and International Child Health
Xiaohan Yan, Mingming Zhu, Qi Feng, Yunqi Yan, Jiangchen Peng, Xitao Xu, Antao Xu, Zhihua Ran
Background and aim: Data on the radiologic evaluation of perianal fistulizing Crohn's disease (PFCD) naïve to anti-tumor necrosis factor therapy are scarce, especially in Asian populations. We assessed the effectiveness of infliximab (IFX) on PFCD and explored predictors of 'deep remission' based on clinical and radiologic assessments. Methods: Patients with Crohn's disease and active anal fistulas attending our care center for IFX therapy were prospectively enrolled...
February 2019: Gastroenterology Report
I L Khalif, B A Nanaeva, M V Shapina, A V Vardanyan
AIM: To assess the effectiveness of conservative treatment of Crohn's disease (CD) with perianal lesions. MATERIALS AND METHODS: The study included 20 patients with CD with perianal fistulae. Prior to the start of conservative therapy, 7 patients underwent fistulae drainage with setton placement. During the study, all patients received therapy with certolizumab pegol (CP) for a year. At the time of treatment initiation and after 12 months, the CD activity index, the quality of life according to IBDQ questionnaires and the perianal Crohn's disease activity index (PCDAI) were assessed...
April 19, 2018: Terapevticheskiĭ Arkhiv
O V Knyazev, N A Fadeeva, A V Kagramanova, N I Belyakov, N V Orlova, A A Lishchinskaya, A G Konoplyannikov, A I Parfenov
AIM: To compare the effectiveness of the effect of combination therapy (local and systemic administration) with bone marrow mesenchymal stromal cells (MSC), anticlitokine therapy with infliximab (IFX), and antibiotic (AB)/immunosuppressive (IS) therapy on the frequency of healing of simple perianal fistulas in Crohn's disease. MATERIALS AND METHODS: In our study, the 1-st group of patients aged 19 to 58 years (Me-29) (n = 12) received MSCs culture systemically according to the scheme and locally...
April 19, 2018: Terapevticheskiĭ Arkhiv
Yunkoo Kang, Sowon Park, Seung Kim, Sang Yong Kim, Hong Koh
Purpose: The efficacy of exclusive enteral nutrition (EEN) with a polymeric diet has not been confirmed in Korean pediatric patients with Crohn's disease (CD). This study aimed to compare the effectiveness of EEN with a specific polymeric diet (Encover®) and corticosteroids (CSs) for the induction of remission in Korean pediatric CD patients. Methods: We retrospectively compared data from 51 pediatric CD patients who underwent induction therapy with EEN (n=19) or CSs (n=32) at Severance Children's Hospital or Incheon St...
January 2019: Pediatric Gastroenterology, Hepatology & Nutrition
Yu Yu, Kang-Chen Chen, Jie Chen
BACKGROUND: Many studies have examined the effects of exclusive enteral nutrition (EEN) in children with Crohn's disease (CD), but corticosteroids are considered a superior therapy and are frequently used in China. This meta-analysis aims to compare the efficacy of EEN with corticosteroids in treating pediatric CD. METHODS: A comprehensive retrieval from medical databases, including PubMed, EMBASE, MEDLINE, Web of Science, Wanfang data, VIP and CNKI, was performed using the search terms "diet therapy", "exclusive enteral nutrition", "Crohn's disease", "inflammatory bowel diseases", "child" and "pediatrics" from January 1990 to April 2017...
January 21, 2019: World Journal of Pediatrics: WJP
Patrizia Alvisi, Serena Arrigo, Salvatore Cucchiara, Paolo Lionetti, Erasmo Miele, Claudio Romano, Alberto Ravelli, Daniela Knafelz, Stefano Martelossi, Graziella Guariso, Salvatore Accomando, Giovanna Zuin, Costantino De Giacomo, Lucio Balzani, Monia Gennari, Marina Aloi
Background: Adalimumab (Ada) treatment is an available option for pediatric Crohn's disease (CD) and the published experience as rescue therapy is limited. Objectives: We investigated Ada efficacy in a retrospective, pediatric CD cohort who had failed previous infliximab treatment, with a minimum follow-up of 6 months. Methods: In this multicenter study, data on demographics, clinical activity, growth, laboratory values (CRP) and adverse events were collected from CD patients during follow-up...
2019: Biologics: Targets & Therapy
Wen-Juan Tang, Kai-Yue Peng, Zi-Fei Tang, Yu-Huan Wang, Ai-Juan Xue, Ying Huang
AIM: To determine whether cell division cycle (Cdc)42 is regulated by microRNA (miR)-15a in the development of pediatric inflammatory bowel disease (IBD). METHODS: We cultured 293T cells, used plasmids and performed dual-luciferase assay to determine whether Cdc42 is a miR-15a target gene. We cultured Caco-2 cells, and stimulated them with tumor necrosis factor (TNF)-α. We then employed lentiviruses to alter the expression of miR-15a and Cdc42. We performed quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunofluorescence to determine whether Cdc42 is regulated by miR-15a in Caco-2 cells...
December 14, 2018: World Journal of Gastroenterology: WJG
Christina Ong, Poh Ting Lim, Veena Logarajah, Maria Janelle Liwanag, Bi Xia Ang, Yuqin Cher, Fang Kuan Chiou, Ajmal Kader
BACKGROUND: Exclusive enteral nutrition (EEN) is as effective as corticosteroids in inducing remission in children with Crohn's disease (CD). However, over 50% of these children relapse by 12 months of diagnosis. Thiopurines are commonly prescribed as maintenance therapy for CD, but evidence for its efficacy is controversial. Data on the effectiveness of EEN in Southeast Asian (SEA) children with CD is scarce. This study aims to evaluate the efficacy of EEN induction therapy in a cohort of SEA children with newly diagnosed CD...
December 12, 2018: BMC Gastroenterology
Mallory Chavannes, Christine Martinez-Vinson, Lara Hart, Nicole Kaniki, Che-Yung Chao, Sally Lawrence, Kevan Jacobson, Jean-Pierre Hugot, Jérome Viala, Colette Deslandres, Prevost Jantchou, Ernest G Seidman
Background: Ustekinumab (UST) is effective in the treatment of adults with moderate to severe Crohn's disease (CD). There is a paucity of data on its use in children. Aim: To evaluate the response to UST in children with moderate to severe CD. Methods: This multi-centre retrospective cohort study identified children under 18 years old with CD who received open-labelled subcutaneous UST. The primary outcome was changes in mean abbreviated PCDAI (aPCDAI) between baseline and 3 and 12 months, and rate of clinical remission at 3 and 12 months...
December 12, 2018: Journal of Crohn's & Colitis
Balázs Szirmay, András Tárnok, Patrícia Sarlós, Nóra Szigeti, Andrea Ludány, Péter Kustán, Zoltán Horváth-Szalai, Attila Miseta, Tamás Kőszegi
BACKGROUND: Laboratory markers are essential tools in the follow-up of patients with Crohn's disease (CD). Our aim was to investigate urinary concentrations of orosomucoid in relation to the inflammatory activity of CD and to compare it with clinical indices and conventional laboratory parameters. MATERIALS AND METHODS: Blood and urine samples of 86 patients (55 adults and 31 children) with CD and 68 healthy individuals (38 adults and 30 children) as controls were analyzed...
November 19, 2018: European Journal of Clinical Investigation
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