Valeria Hasenmajer, Dario De Alcubierre, Davide Ferrari, Marianna Minnetti, Ilaria Bonaventura, Riccardo Pofi, Chiara Simeoli, Alessandra Tomaselli, Francesca Sciarra, Grazia Bottillo, Francesco Angelini, Alessia Cozzolino, Mary Anna Venneri, Emmanuele A Jannini, Daniele Gianfrilli, Rosario Pivonello, Andrea M Isidori
BACKGROUND: Data on sexual function in patients with adrenal insufficiency are scarce and largely controversial. OBJECTIVES: To investigate sexual dysfunction in patients with primary and secondary adrenal insufficiency and the effects of switching to once-daily dual-release hydrocortisone on sexual function in outcome assessors blinded, randomized, multicenter, active comparator clinical trial. MATERIALS AND METHODS: Eighty-nine adrenal insufficiency patients on conventional, multiple daily doses of glucocorticoid replacement, enrolled in the Dual RElease hydrocortisone versus conventionAl glucocorticoid replaceMent in hypocortisolism (DREAM) trial, were randomly assigned to continue their therapy or to switch to an equivalent dose of dual-release hydrocortisone...
March 28, 2024: Andrology