Víctor Antonio Malagón-Soriano, Andres Julian Ledezma-Forero, Cristian Felipe Espinel-Pachon, Álvaro Javier Burgos-Cárdenas, Maria Fernanda Garces, Gustavo Eduardo Ortega-Ramírez, Roberto Franco-Vega, Jhon Jairo Peralta-Franco, Luis Miguel Maldonado-Acosta, Jorge Andres Rubio-Romero, Manuel Esteban Mercado-Pedroza, Sofia Alexandra Caminos-Cepeda, Ezequiel Lacunza, Carlos Armando Rivera-Moreno, Aquiles Enrique Darghan-Contreras, Ariel Iván Ruiz-Parra, Jorge E Caminos
BACKGROUND: Overweight and obesity, high blood pressure, hyperglycemia, hyperlipidemia, and insulin resistance (IR) are strongly associated with non-communicable diseases (NCDs), including type 2 diabetes, cardiovascular disease, stroke, and cancer. Different surrogate indices of IR are derived and validated with the euglycemic-hyperinsulinemic clamp (EHC) test. Thus, using a computational approach to predict IR with Matsuda index as reference, this study aimed to determine the optimal cutoff value and diagnosis accuracy for surrogate indices in non-diabetic young adult men...
2024: Frontiers in Endocrinology