Satoshi Nagaoka, Daisaku Yamada, Hidetoshi Eguchi, Yuki Yokota, Yoshifumi Iwagami, Tadafumi Asaoka, Takehiro Noda, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Eiji Miyoshi, Yuichiro Doki, Masaki Mori
Interleukin-33 (IL-33), an alarmin released during tissue injury, facilitates the development of cholangiocarcinoma (CCA) in a murine model. However, it is unclear whether IL-33 is associated with human CCA. The aim of this study was to support the following hypothesis: IL-33 is released during hepatectomy for CCA, subsequently facilitating the development of subclinical CCA and eventually leading to recurrent disease. IL-33 expression was assessed in various samples from both humans and mice including resected liver and paired plasma samples collected at hepatectomy and after surgery, and its influences on recurrent disease and patient prognosis were determined...
October 24, 2020: Cancer Science
Heba Saed El-Amawy, Sameh Magdy Sarsik
BACKGROUND: Saline, with its different concentrations, is the most used crystalloid solution in medicine. In dermatology, no large studies investigated the benefits of saline. The aim of this article is to review the different possible uses of saline in dermatology, in order to give final recommendations based on the literature review and our experience. METHODS: We performed a literature search based on PubMed, Embase, WHO Global Health Library, Virtual Health Library, Web of science, Scopus, Google scholar and Research gate...
October 24, 2020: Journal of Cosmetic Dermatology
Amir Darb Emamie, Mohammadreza Rajabpour, Roya Ghanavati, Parisa Asadolahi, Sorour Farzi, Behnam Sobouti, Atieh Darbandi
AIMS: To perform a systematic review on randomized controlled trials to examine the efficacy of probiotics, prebiotics and synbiotics in the treatment of IBD. METHODS AND RESULTS: PubMed, Web of science, Scopus, and Google Scholar were systematically searched from January 2009 to January 2020 using the following keywords: "Inflammatory Bowel Disease", "Probiotics" and "Clinical trial". The statistical analysis was performed using SPSS software version 24...
October 24, 2020: Journal of Applied Microbiology
Philippe Rouanet, Michel Rivoire, Sophie Gourgou, Bernard Lelong, Eric Rullier, Merhdad Jafari, Laurent Mineur, Marc Pocard, Jean Luc Faucheron, François Dravet, Denis Pezet, Jean Michel Fabre, Laurent Bresler, Jacques Balosso, Christophe Taoum, Claire Lemanski
BACKGROUND: Rate of abdominoperineal resection (APR) varies from countries and surgeons. Surgical impact of preoperative treatment for ultra-low rectal carcinoma (ULRC) initially indicated for APR is debated. We report the 10-year oncological results from a prospective controlled trial (GRECCAR 1) which evaluate the sphincter saving surgery (SSR). METHODS: ULRC indicated for APR were included (n = 207). Randomization was between high-dose radiation (HDR, 45 + 18 Gy) and radiochemotherapy (RCT, 45 Gy + 5FU infusion)...
October 24, 2020: Journal of Surgical Oncology
Pilar Golmayo, Lucía Barallat, Meritxell Losada, Cristina Vallés, Jose Nart, Andrés Pascual-La Rocca
AIM: The primary goal was to compare the amount of keratinized tissue width (KTW) gain after free gingival graft (FGG) procedures around implants and teeth after 6 and 12 months of healing. MATERIAL AND METHODS: Patients with mucogingival defects (<2 mm of KT) around teeth and implants underwent a gingival augmentation procedure by means of a FGG. Clinical measurements were performed with an individual stent to determine keratinized tissue width (KTW), length (KTL), graft shrinkage (GS) and gingival margin position (GMP) at 2 weeks, 6 weeks, 3 months, 6 months and 12 months after surgery...
October 24, 2020: Journal of Clinical Periodontology
Brian Fiani, Juliana Runnels, Ashley Taylor, Manraj Sekhon, Daniel Chacon, Michael McLarnon, Rebecca Houston, Sasha Vereecken
Spinal injury is among the most severe and feared injuries an athlete may face. We present an up-to-date review of the recent literature, stratifying recommendations based on injury location (cervical, thoracic, and lumbar spine) and type, as well as, the level of competitive play (high school, collegiate, professional). A literature search was completed to identify all publications reporting return to play guidelines for athletic injuries or injury-related surgery irrespective of the study design. Publication dates were not restricted by year...
October 26, 2020: Reviews in the Neurosciences
Cindy Cy Law, Conor Bell, Deborah Koh, Yueyang Bao, Vipul Jairath, Neeraj Narula
BACKGROUND: Medications used to treat inflammatory bowel disease (IBD) have significantly improved patient outcomes and delayed time to surgery. However, some of these therapies are recognized to increase the general risk of infection and have an unclear impact on postoperative infection risk. OBJECTIVES: To assess the impact of perioperative IBD medications on the risk of postoperative infections within 30 days of surgery. SEARCH METHODS: We searched the Cochrane IBD Group's Specialized Register (29 October 2019), MEDLINE (January 1966 to October 2019), Embase (January 1985 to October 2019), the Cochrane Library, ClinicalTrials...
October 24, 2020: Cochrane Database of Systematic Reviews
Amit Akirov, Hiba Masri-Iraqi, Alexander Gorshtein, Hadar Duskin-Bitan, Keren Kaminer, Ilan Shimon
AIM: The aim of this study is to assess the benefits of a nurse-led home injection service for somatuline autogel-treated patients with acromegaly, including the adherence to treatment and disease control. METHODS: Historical prospective data of all patients with acromegaly initiating somatuline autogel between November 14, 2000, and March 9, 2020, who voluntarily enrolled in the nurse-led home injection service between January 1, 2018 and June 30, 2020. Adherence to treatment was calculated as the number of administered injections divided by the number of expected injections during the follow-up period...
October 24, 2020: Endocrine
Lars Walczak, Lennart Tautz, Mathias Neugebauer, Joachim Georgii, Isaac Wamala, Simon Sündermann, Volkmar Falk, Anja Hennemuth
PURPOSE: Decision support systems for mitral valve disease are an important step toward personalized surgery planning. A simulation of the mitral valve apparatus is required for decision support. Building a model of the chordae tendineae is an essential component of a mitral valve simulation. Due to image quality and artifacts, the chordae tendineae cannot be reliably detected in medical imaging. METHODS: Using the position-based dynamics framework, we are able to realistically simulate the opening and closing of the mitral valve...
October 24, 2020: International Journal of Computer Assisted Radiology and Surgery
Amanda L Merriman, Michael J Kennelly
PURPOSE OF REVIEW: Pelvic organ prolapse (POP) is a common condition and there is a plethora of surgical techniques available to address this problem. We present a review of biologic grafts, including the latest literature to help guide a surgeon's choice on the type of biologic materials to augment repairs. RECENT FINDINGS: Since the 2019 Food and Drug Administration (FDA) ban on mesh, including xenograft, there is a sparsity of biologic graft products available for POP repairs...
October 24, 2020: Current Urology Reports
Rachel Houten, Nigel Fleeman, Eleanor Kotas, Angela Boland, Tosin Lambe, Rui Duarte
PURPOSE: Health state utility values are commonly used to inform economic evaluations and determine the cost-effectiveness of an intervention. The aim of this systematic review is to summarise the utility values available to represent the health-related quality of life (HRQoL) of patients with thyroid cancer. METHODS: Eight electronic databases were searched from January 1999 to April 2019 for studies which included assessment of HRQoL for patients with thyroid cancer...
October 24, 2020: Quality of Life Research
Benoit Peyronnet, Tamsin Greenwell, Gary Gray, Rose Khavari, Nikesh Thiruchelvam, Grégoire Capon, Jeremy Ockrim, Luis Lopez-Fando, Jason Gilleran, Georges Fournier, Gommert A Van Koeveringe, Frank Van Der Aa
PURPOSE OF REVIEW: The aim of the present report was to review the recent evidences regarding the use of artificial urinary sphincter (AUS) in adult females. RECENT FINDINGS: While the excellent functional outcomes of AUS in female patients with stress urinary incontinence (SUI) due to intrinsic sphincter deficiency (ISD) have been reported for decades, its use has remained confidential in most countries likely due to its challenging implantation and inherent morbidity...
October 24, 2020: Current Urology Reports
Timo J Schwarz, Günther Maderbacher, Franziska Leiss, Joachim Grifka, G Heers, J Matussek
INTRODUCTION: Bernese periacetabular osteotomy is an effective procedure for treating acetabular dysplasia. However, limited visual control of the acetabular position during surgery may result in under- or overcorrection with residual dysplasia or femoroacetabular impingement. Thus, we wanted to find a simple method to control the effect of correction in the sagittal and coronal plane. METHOD: The acetabular coordinates are shown by two perpendicular tubes of an external fixator mounted onto a third tube that is fixed to the acetabular fragment with two Schanz screws...
October 24, 2020: Archives of Orthopaedic and Trauma Surgery
Oliver Taylor, Jeffrey Niu Li, Christian Carr, Antonio Garcia, Sophia Tran, Divya Srivastava, Rajiv I Nijhawan
As data and recommendations regarding antibiotic prophylaxis in dermatologic surgery vary, we tried to describe the effect of antibiotic prophylaxis (AP) in Mohs micrographic surgery (MMS) on infective endocarditis, prosthetic joint infection, and surgical site infection using a single-institution retrospective cohort study of antibiotic use (pre-/intra-operative, post-operative or none) among 2,364 patient encouters treated with MMS. Bivariate logistic regression was evaluated for associations between patient and operative characteristics, antibiotic use, and infectious complications...
October 24, 2020: Archives of Dermatological Research
Richard Drexler, Mirco Küchler, Kim C Wagner, Tim Reese, Bernd Feyerabend, Moritz Kleine, Karl J Oldhafer
PURPOSE: The Hippo pathway has broadened in cancer research in the past decade and revealed itself to be an important driver for tumorigenesis and metastatic spread. In this study, we investigated the clinical relevance of the Hippo pathway with regard to metastatic invasion, patients' outcome and histopathological features. METHODS: Protein expression of components of the Hippo pathway were analyzed by immunohistochemistry (IHC) using paraffin-embedded tissue from 103 patients who had been diagnosed with pancreatic ductal adenocarcinoma and had undergone surgery...
October 24, 2020: Journal of Cancer Research and Clinical Oncology
Vivek Agarwal, Paramjeet Singh, Chirag K Ahuja, Sunil Kumar Gupta, Ashish Aggarwal, Rajashekhar Narayanan
PURPOSE: Cerebral hyperperfusion syndrome (CHPS) can result after anastomotic surgery as the reperfusion is established in chronically ischemic cerebral territories in patients of moyamoya disease (MMD). In this study, we have evaluated the feasibility of arterial spin labelling (ASL) perfusion MRI to predict cerebral hyperperfusion syndrome based on changes of cerebral blood flow (CBF) after revascularisation surgery in patients of MMD. METHODS: Our prospective study included 25 patients with MMD who underwent superficial temporal artery-middle cerebral artery (STA-MCA) bypass with or without dural/muscle synangiosis...
October 24, 2020: Neuroradiology
Katie J Sheehan, Aicha Goubar, Orouba Almilaji, Finbarr C Martin, Chris Potter, Gareth D Jones, Catherine Sackley, Salma Ayis
OBJECTIVE: To determine whether mobilisation timing was associated with the cumulative incidence of hospital discharge by 30 days after hip fracture surgery, accounting for potential confounders and the competing risk of in-hospital death. METHOD: We examined data for 135,105 patients 60 years or older who underwent surgery for nonpathological first hip fracture between 1 January 2014 and 31 December 2016 in any hospital in England or Wales. We tested whether the cumulative incidences of discharge differed between those mobilised early (within 36 h of surgery) and those mobilised late, accounting for potential confounders and the competing risk of in-hospital death...
October 24, 2020: Age and Ageing
Raja Jayaram, Michael Jones, Svetlana Reilly, Mark J Crabtree, Nikhil Pal, Nicola Goodfellow, Keshav Nahar, Jillian Simon, Ricardo Carnicer, Ravi DeSilva, Chandana Ratnatunga, Mario Petrou, Rana Sayeed, Andrea Roalfe, Keith M Channon, Yaver Bashir, Timothy Betts, Michael Hill, Barbara Casadei
AIMS: Systemic inflammation and increased activity of atrial NOX2-containing NADPH oxidases have been associated with the new onset of atrial fibrillation (AF) after cardiac surgery. In addition to lowering LDL-cholesterol, statins exert rapid anti-inflammatory and antioxidant effects, the clinical significance of which remains controversial. METHODS AND RESULTS: We first assessed the impact of cardiac surgery and cardiopulmonary bypass (CPB) on atrial nitroso-redox balance by measuring NO synthase (NOS) and GTP Cyclohydrolase -1 (GCH-1) activity, biopterin content, and superoxide production in paired samples of the right atrial appendage obtained before (PRE) and after CPB and reperfusion (POST) in 116 patients...
October 24, 2020: Cardiovascular Research
Mahi Mahmoud Al-Tehewy, Sara Ebraheem Abd Al-Razak, Tamer Shahat Hikal, Maha Magdy Wahdan
PURPOSE: Patient safety indicators (PSIs) were developed as a tool for hospitals to identify potentially preventable complications and improve patient safety performance. The study aimed at measuring the incidence of the Agency for Healthcare Research and Quality (AHRQ) PSI03 (pressure ulcer [PU] rate) and to identify the association between PSI03 and clinical outcomes including death, readmission within 30 days and length of stay (LOS) at the cardiothoracic surgery hospital at Ain Shams University, Cairo, Egypt...
October 27, 2020: International Journal of Health Care Quality Assurance
Habib Khoury, Nikhil Bellamkonda, Peyman Benharash, Jivianne T Lee, Marilene B Wang, Jeffrey D Suh
OBJECTIVES: To characterize the incidence, causes, risk factors, and costs of 30-day readmission after inpatient functional endoscopic sinus surgery (FESS) for patients with chronic rhinosinusitis. STUDY DESIGN: Retrospective cohort study. METHODS: The Nationwide Readmissions Database was used to characterize readmission after inpatient sinus surgery for chronic rhinosinusitis from 2015 to 2017. International Classification of Disease codes were used to identify the patient population, which included 5,644 patients...
October 24, 2020: Laryngoscope
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