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JOURNAL ARTICLE
Humaira Hanif, Obaidullah Ahmed, James Manifield, Rubia Ishrat, Ilaria Pina, Zahira Ahmed, Mohd Shibli, Dominic Malcolm, Deepak Talwar, Sally J Singh, Mark W Orme
OBJECTIVES: Pulmonary Rehabilitation (PR) is a high-impact intervention for individuals with idiopathic pulmonary fibrosis (IPF) but access is limited in India. PR barriers include distance to travel, lack of service provision and lack of healthcare professionals to deliver PR, thus it is disproportionate to the immense burden of IPF in India. We explored the lived experiences of people living with IPF, family caregivers (CGs) and healthcare workers (HCWs) as well as their views towards home-based PR (HBPR) in Delhi, India...
2024: Chronic Respiratory Disease
#2
RANDOMIZED CONTROLLED TRIAL
Marina Shah, Shahbaz Ahmed Jat, Munazza Aziz
OBJECTIVE: To compare the effect of propolis and gluma desensitisers on the management of dentin hypersensitivity. METHODS: The single-blind, randomised controlled trial was conducted at the Department of Operative Dentistry, Dr Ishrat ul Ebad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi, from October 2020 to September 2021, and comprised patients with dentin hypersensitivity who had pain scores of at least 2 on the visual analogue scale...
May 2024: JPMA. the Journal of the Pakistan Medical Association
#3
JOURNAL ARTICLE
Ishrat Zahan, Md Kamrujjaman
This study explores a spatially distributed harvesting model that signifies the outcome of the competition of two species in a heterogeneous environment. The model is controlled by reaction-diffusion equations with resource-based diffusion strategies. Two different situations are maintained by the harvesting effects: when the harvesting rates are independent in space and do not exceed the intrinsic growth rate; and when they are proportional to the time-independent intrinsic growth rate. In particular, the competition between both species differs only by their corresponding migration strategy and harvesting intensity...
May 30, 2024: Heliyon
#4
JOURNAL ARTICLE
Hina Sharif, Sana Sharif Sheikh, Ambreen Salman, Zahida Jawed, Ishrat Karim, Tehseena Sohail, Nadia Mohsin
Insulin resistance complicates diabetes care. Its effectiveness and tolerability as an addition to metformin, DPP4 inhibitor and insulin treatment in type 2 diabetic patients will be examined in this research. Participants with type 2 diabetes from poor socio-economic backgrounds had HbA1c values ≥8.5% when using Insulin+Metformin+DPP-4 inhibitors. They received 10mg Empagliflozin daily for 12 weeks (n=143). The main outcome was change in HbA1c at 12th week from baseline. Secondary outcomes were baseline weight and week 12 FPG...
March 2024: Pakistan Journal of Pharmaceutical Sciences
#5
JOURNAL ARTICLE
Megan L Rogers, Jenelle A Richards, Devon Peterkin, Ji Yoon Park, Claudia I Astudillo-García, Shira Barzilay, Yarden Blum, Ksenia Chistopolskaya, Manuela Dudeck, Sergey Enikolopov, M Ishrat Husain, Alberto Jiménez, Fatma Kantas Yilmaz, Oskar Kuśmirek, Ming-Been Lee, Vikas Menon, Jefté Peper-Nascimento, Barbara Pilecka, Judith Streb, Başak Ünübol, Samira S Valvassori, Maria Valeria Contreras, Chia-Yi Wu, Sungeun You, Igor Galynker
INTRODUCTION: The suicide crisis syndrome (SCS) has demonstrated efficacy in predicting suicide attempts, showing potential utility in detecting at-risk individuals who may not be willing to disclose suicidal ideation (SI). The present international study examined differences in intentions to utilize mental health and suicide prevention resources among community-based adults with varying suicide risk (i.e., presence/absence of SCS and/or SI). METHODS: A sample of 16,934 community-based adults from 13 countries completed measures about the SCS and SI...
May 15, 2024: Suicide & Life-threatening Behavior
#6
JOURNAL ARTICLE
Nazma Shaheen, Towhid Hasan, Marjia Sultana, Kazi Turjaun Akhter, Ishrat Nourin Khan, Nafis Md Irfan, Md Kawser Ahmed
The study aimed to assess the level of potentially toxic elements (As, Cd, Pb, Zn, Cu, Cr, Mn, and Ni) and associated health implications through commonly consumed rice cultivars of Bangladesh available in Capital city, Dhaka. The range of As, Cd, Pb, Zn, Cu, Cr, Mn, and Ni in rice grains were 0.04-0.35, 0.01-0.15, 0.01-1.18, 10.74-34.35, 1.98-13.42, 0.18-1.43, 2.51-22.08, and 0.21-5.96 mg/kg fresh weight (FW), respectively. The principal component analysis (PCA) identified substantial anthropogenic activities to be responsible for these elements in rice grains...
2024: PloS One
#7
JOURNAL ARTICLE
Nayab Ishrat, Annie Gupta, Mohd Faheem Khan, Uzma Shahab, Mohd Shahnawaz Khan, Naved Ahmad, Kirtanjot Kaur, Saheem Ahmad, Abbas Ali Mahdi
Nymphaea rubra (N. rubra) flowers are prevalent in subtropical regions for both dietary and traditional medicinal purposes, attributing to their beneficial properties in supporting overall health. This study first time provides descriptions of the antidiabetic and dyslipidemic properties employing STZ induced high fat diet fed diabetic rats and inhibition of α-amylase enzyme activity first by in vitro analyses, followed by a confirmatory in silico study to create a stronger biochemical rationale. Furthermore, in 3 T3-L1 cells, this extract promoted the suppression of adipogenesis...
May 11, 2024: Fitoterapia
#8
JOURNAL ARTICLE
Ramgopal Dudwal, Bhanwar Lal Jakhar, Abdul Rashid Khan Pathan, Alka Kataria, Shish Ram Dhaka, Ishrat Jan, R Z Sayyed, Aarif Khan, Ling Shing Wong, Vinoth Kumarasamy, Gaurav Gupta, Vetriselvan Subramaniyan, Naveed A Malik
Chilli is an indispensable food item in the daily life of humans but it is affected by many insects, so various pesticides, including spiromesifen, are applied to chilli crops to protect this crop from insect infestation. However, the use of pesticides poses environmental and health issues. These issues have raised the demand for pesticide-free chillies among consumers. The primary aim of this study was to assess the efficacy of various decontamination methods in removing spiromesifen residues from chilli fruits...
May 15, 2024: Heliyon
#9
JOURNAL ARTICLE
Mao Li, Gang Fang, Fatima Zahid, Raheela Saleem, Ghazala Ishrat, Zakir Ali, Muhammad Naeem, Fakhar Ud Din
The objective of this study was to develop nanotechnology-mediated paclitaxel (PAC) and curcumin (CUR) co-loaded solid lipid nanoparticles (PAC-CUR-SLNs) for the treatment of lung cancer, which is a leading cause of death worldwide. Around 85 % cases of lungs cancer constitute non-small cell lung cancer (NSCLC). PAC-CUR-SLNs were prepared via high pressure homogenization. The in vitro drug release of PAC-CUR-SLNs was checked followed by their in vitro cytotoxic investigation using adenocarcinomic human alveolar basal epithelial cells (A549) cell lines...
May 15, 2024: Heliyon
#10
REVIEW
Raymond W Lam, Sidney H Kennedy, Camelia Adams, Anees Bahji, Serge Beaulieu, Venkat Bhat, Pierre Blier, Daniel M Blumberger, Elisa Brietzke, Trisha Chakrabarty, André Do, Benicio N Frey, Peter Giacobbe, David Gratzer, Sophie Grigoriadis, Jeffrey Habert, M Ishrat Husain, Zahinoor Ismail, Alexander McGirr, Roger S McIntyre, Erin E Michalak, Daniel J Müller, Sagar V Parikh, Lena S Quilty, Arun V Ravindran, Nisha Ravindran, Johanne Renaud, Joshua D Rosenblat, Zainab Samaan, Gayatri Saraf, Kathryn Schade, Ayal Schaffer, Mark Sinyor, Claudio N Soares, Jennifer Swainson, Valerie H Taylor, Smadar V Tourjman, Rudolf Uher, Michael van Ameringen, Gustavo Vazquez, Simone Vigod, Daphne Voineskos, Lakshmi N Yatham, Roumen V Milev
BACKGROUND: The Canadian Network for Mood and Anxiety Treatments (CANMAT) last published clinical guidelines for the management of major depressive disorder (MDD) in 2016. Owing to advances in the field, an update was needed to incorporate new evidence and provide new and revised recommendations for the assessment and management of MDD in adults. METHODS: CANMAT convened a guidelines editorial group comprised of academic clinicians and patient partners. A systematic literature review was conducted, focusing on systematic reviews and meta-analyses published since the 2016 guidelines...
May 6, 2024: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
#11
REVIEW
Hanan Javid, Ishrat Shaheen, Roof Ul Qadir, Junaid Ahmad Magray, Bilal Ahmad Wani, Irshad A Nawchoo, Shabana Gulzar
The genus Bistorta comprises about 43 accepted species that are widely used by local people and medicinal practitioners for the treatment of rheumatism, tuberculosis, inflammation, respiratory infection, and other diseases. The objective of this review is to present up-to-date information from the scientific literature about the phytochemistry, pharmacology, and toxicology of Bistorta. At present, there is a lack of a comprehensive review that consolidates the various scientific studies conducted on the genus Bistorta...
April 30, 2024: Fitoterapia
#12
JOURNAL ARTICLE
Ramzi Halabi, Christina Gonzalez-Torres, Stephane MacLean, M Ishrat Husain, Abhishek Pratap, Martin Alda, Benoit H Mulsant, Abigail Ortiz
Bipolar disorder (BD) is a mood disorder with different phases alternating between euthymia, manic or hypomanic episodes, and depressive episodes. While motor abnormalities are commonly seen during depressive or manic episodes, not much attention has been paid to postural abnormalities during periods of euthymia and their association with illness burden. We collected 24-hour posture data in 32 euthymic participants diagnosed with BD using a shirt-based wearable. We extracted a set of nine time-domain features, and performed unsupervised participant clustering...
May 1, 2024: IEEE Journal of Biomedical and Health Informatics
#13
REVIEW
Andreea Chiorean, Brett D M Jones, Mijia Murong, Christina Gonzalez-Torres, Stefan Kloiber, Abigail Ortiz, Joshua D Rosenblat, Benoit H Mulsant, M Ishrat Husain
OBJECTIVES: Clinicians are often hesitant to prescribe psychostimulants in bipolar disorder (BD) due to concerns of inducing (hypo)mania, despite limited published evidence on associations between prescribed psychostimulant use and recurrence of mood episodes in BD. The current systematic review and meta-analysis evaluated the emergence of (hypo)manic symptoms in patients with BD receiving prescribed psychostimulants or other pro-cognitive medications in euthymic or depressive states...
April 26, 2024: Bipolar Disorders
#14
JOURNAL ARTICLE
James Zhang, Florence Bradshaw, Ishrat Hussain, Ioannis Karamatzanis, Michal Duchniewicz, Matija Krkovic
INTRODUCTION: Understanding the epidemiology and incidence of fractures can help inform policymakers and clinicians about the needs of the population and highlight trends over time, allowing for tailoring of healthcare delivery to the population. This study reports on the lower limb fractures treated at a major trauma centre over a seven-year period. METHODS: We collected data on fracture locations, age, gender, BMI, hospital admission length, and treatment options of all lower limb fractures treated at a level I trauma centre from January 2015 to December 2021...
March 2024: Curēus
#15
JOURNAL ARTICLE
Varsha Singh, Payal Mandal, Shweta Singh Chauhan, Ishrat Jahan Saifi, Marhaba, P V Sandeep, Pankaj Jagdale, Anjaneya Ayanur, Kausar Mahmood Ansari
BACKGROUND: Zearalenone (ZEA), a natural food contaminant, is reported to act as a mycoestrogen due to its estrogen-mimicking properties. According to studies, ZEA has a greater potential for estrogenic activity compared to any other naturally occurring non-steroidal estrogen. ZEA has been found in the endometrium of individuals with reproductive problems and the serum of children facing early puberty. These studies suggested a possible link between ZEA exposure and endometrial toxicity; nonetheless, no thorough research has been done...
April 2024: Toxicology Research
#16
JOURNAL ARTICLE
Brett D M Jones, M Ishrat Husain
No abstract text is available yet for this article.
April 16, 2024: Neuropsychopharmacology
#17
JOURNAL ARTICLE
Lisa J Cohen, Yinan Liang, Devon Peterkin, Kamryn McGibbon, Frank Rappa, Megan L Rogers, Sungeun You, Ksenia Chistopolskaya, Sergey Enikolopov, Shira Barzilay, Vikas Menon, M Ishrat Husain, Manuela Dudeck, Judith Streb, Elif Çinka, Fatma Kantas Yilmaz, Oskar Kuśmirek, Samira S Valvassori, Yarden Blum, Igor Galynker
OBJECTIVE: The COVID-19 pandemic has had a globally devastating psychosocial impact. A detailed understanding of the mental health implications of this worldwide crisis is critical for successful mitigation of and preparation for future pandemics. Using a large international sample, we investigated in the present study the relationship between multiple COVID-19 parameters (both disease characteristics and government responses) and the incidence of the suicide crisis syndrome (SCS), an acute negative affect state associated with near-term suicidal behavior...
April 15, 2024: Disaster Medicine and Public Health Preparedness
#18
REVIEW
Siqi Xue, Alessandro Massazza, Samia C Akhter-Khan, Britt Wray, M Ishrat Husain, Emma L Lawrance
The evidence on the impacts of climate change on mental health and wellbeing is growing rapidly. The objective of this scoping review is to understand the extent and type of existing mental health and psychosocial interventions aimed at addressing the mental health and psychosocial impacts of climate change. A scoping review methodology was followed. MEDLINE, PsycINFO, and Web of Science databases were searched from inception to May 2022. Comprehensive gray literature search, including expert consultation, was conducted to identify interventions for which peer-reviewed academic literature may not yet be available...
March 12, 2024: Npj Ment Health Res
#19
JOURNAL ARTICLE
Zakir Amin, Parveez Ahmad Sheikh, Ishrat Jan, Baby Summuna, Alamgir Ahmad Dar, Fazil Fayaz Wani, Zahoor Ahmad Bhat
This study aimed to investigate the dissipation pattern, risk assessment, and waiting period of myclobutanil on apple fruit (Malus domestica Borkh.) under temperate conditions in Kashmir, India. The study involved the application of myclobutanil 10 WP at a single recommended dosage (125 g a.i. ha-1 ) and double dosage (250 g a.i. ha-1 ) on Red Velox apple trees, 2 months before harvest. GC equipped with an electron capture detector was used to analyze myclobutanil residues in fruit samples...
April 10, 2024: Biomedical Chromatography: BMC
#20
JOURNAL ARTICLE
Jairus Olumasai Nandwa, Azhar Mehmood, Ishrat Mahjabeen, Kayode Yomi Raheem, Mamoudou Hamadou, Mouhamed Z K A Raimi, Mahmood A Kayani
AKT2 is crucial for cancer cells' invasion, metastasis, and survival. It is a possible downstream gene target of cancer glycolysis-related microRNAs. The study investigated the role of miRNA-4716-3p, rs2304186, and the AKT2 gene in blood cancer pathogenesis. RT-qPCR was used to analyze AKT2 gene mRNA and miRNA-4716-3p expression in 200 blood cancer samples and 200 healthy controls. Furthermore, Tetra-ARMS PCR was used to examine the rs2304186 AKT2 SNP in 300 patients and 290 control samples. miRNA-4716-3p was shown to be significantly downregulated (p = 0...
September 2024: Non-Coding RNA Research
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