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JOURNAL ARTICLE
Katharina Heck, Svetlana Malinina, Anja Palmowski
No abstract text is available yet for this article.
April 2024: Klinische Monatsblätter Für Augenheilkunde
#2
JOURNAL ARTICLE
May Ameri, Nagham Al-Zubidi, Andrew G Lee
Immunotherapy has renovated the field of oncology. Usually, cancer is treated by surgery, chemotherapy, and radiation. Immunotherapy is a promising treatment that harnesses the patient's own immune system to target cancer. Immune checkpoint inhibitors (ICIs) have proven to be a promising treatment avenue for managing cancer; however, their use had been associated with a unique spectrum of adverse side effects called immune-related adverse events (irAEs). As ICIs become increasingly relevant in cancer management, it is crucial to address these irAEs affecting various systems in the body, including the skin, liver, gastrointestinal tract, endocrine system, and the eye...
2024: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
#3
JOURNAL ARTICLE
Kowsigan Magesan, Parthopratim D Majumder, Mamta Agarwal, Amala E George, Vinita Nair, Sudha K Ganesh, Jyotirmay Biswas
PURPOSE: To report the clinical pattern of surgically induced necrotizing scleritis (SINS) in a tertiary eye care center in Southern India. METHODS: Retrospective analysis of all SINS cases visiting the uveitis clinic of a tertiary eye institute between January 2009 and April 2019. RESULTS: In total, 15 patients with a median age of 65 (IQR:52-70) years were included in the study. Male (53%) predominance was noted, and SINS was unilateral (100%) in all cases...
April 16, 2024: Indian Journal of Ophthalmology
#4
David-Ionuț Beuran, Mioara-Laura Macovei, Ioana Ruxandra Boca
Objective: Our purpose was to present a case of a patient diagnosed with herpes zoster ophthalmicus with multiple ocular manifestations. Case presentation: A 70-year-old Caucasian male presented to the hospital for headache and skin hyperesthesia on the scalp and forehead on the left side. The diagnoses of herpes zoster ophthalmicus and acute conjunctivitis were made for the left eye. The patient was followed up for 6 months and during that period the following diagnoses were made for the same eye: peripheral sterile corneal infiltrates, episcleritis, and hypertensive anterior uveitis...
2024: Romanian Journal of Ophthalmology
#5
REVIEW
Sonny Caplash, Manuel Paez-Escamilla, Mark Westcott, Kunal K Dansingani, Chad Indermill, Nacima Kisma, Eric Frau, Jose-Alain Sahel, Bahram Bodaghi, Vishal Jhanji, Marie-Helene Errera
BACKGROUND: Anterior uveitis, inflammation of the anterior chamber and related structures, is a cohort of diseases that can present to almost any general or sub-specialty Ophthalmology practice. Its features classically involve anterior chamber cell and flare. Below the surface of these two signs exist a panoply of diagnoses. BODY: The purpose of this review is to provide a general framework for diagnoses of anterior uveitis that are often missed as well as non-uveitic pathologies that often mimic anterior uveitis...
April 10, 2024: Journal of Ophthalmic Inflammation and Infection
#6
JOURNAL ARTICLE
Mustafa Kayabaşı, Işıl Kefeli, Pınar Çakar Özdal, Ali Osman Saatci
INTRODUCTION: A case of ocular bartonellosis under anti-tumour necrosis factor treatment is described. CASE DESCRIPTION: A 29-year-old woman with psoriasis who had been on certolizumab treatment was examined with a left visual deterioration following a fever bout, malaise, and placoid erythematous rashes on her neck. As there was acute anterior uveitis in her left eye, it was recommended to stop certolizumab treatment for a possible infectious aetiology. However, her physician elected to continue the certolizumab treatment...
2024: European Journal of Case Reports in Internal Medicine
#7
JOURNAL ARTICLE
Karoline Baquet-Walscheid, Thomas Rath, Arnd Heiligenhaus
Ocular manifestations of rheumatic diseases are common and contribute significantly to the morbidity and reduced quality of life of affected patients. Knowledge of typical clinical manifestations is important for the rheumatologist in order to support the reference of patients with corresponding symptoms for ophthalmological consultation at an early stage of disease, or to initiate regular screening examinations (e.g. in patients with Behçet's syndrome). Conversely, a (possibly urgent) rheumatological assessment is crucial for certain ophthalmological diseases, in order not to overlook a (possibly fatal) systemic associated disease...
April 4, 2024: Klinische Monatsblätter Für Augenheilkunde
#8
JOURNAL ARTICLE
Antonio Vitale, Valeria Caggiano, Eduardo Martin-Nares, Micol Frassi, Lorenzo Dagna, Pravin Hissaria, Paolo Sfriso, José Hernández-Rodríguez, Guillermo Ruiz-Irastorza, Sara Monti, Abdurrahman Tufan, Matteo Piga, Henrique A Mayrink Giardini, Giuseppe Lopalco, Ombretta Viapiana, Amato De Paulis, Paola Triggianese, Rosetta Vitetta, Alejandra de-la-Torre, Alex Fonollosa, Federico Caroni, Jurgen Sota, Edoardo Conticini, Jessica Sbalchiero, Alessandra Renieri, Giulia Casamassima, Ewa Wiesik-Szewczyk, Derya Yildirim, Andrea Hinojosa-Azaola, Francesca Crisafulli, Franco Franceschini, Corrado Campochiaro, Alessandro Tomelleri, Alicia Callisto, Mark Beecher, Sara Bindoli, Chiara Baggio, Verónica Gómez-Caverzaschi, Laura Pelegrín, Adriana Soto-Peleteiro, Alessandra Milanesi, Ibrahim Vasi, Alberto Cauli, Isabele Parente de Brito Antonelli, Florenzo Iannone, Riccardo Bixio, Francesca Della Casa, Ilaria Mormile, Carmelo Gurnari, Alessia Fiorenza, Germán Mejia-Salgado, Perla Ayumi Kawakami-Campos, Gaafar Ragab, Francesco Ciccia, Piero Ruscitti, Monica Bocchia, Alberto Balistreri, Gian Marco Tosi, Bruno Frediani, Luca Cantarini, Claudia Fabiani
VEXAS syndrome is a recently described monogenic autoinflammatory disease capable of manifesting itself with a wide array of organs and tissues involvement. Orbital/ocular inflammatory manifestations are frequently described in VEXAS patients. The objective of this study is to further describe orbital/ocular conditions in VEXAS syndrome while investigating potential associations with other disease manifestations. In the present study, twenty-seven out of 59 (45.8 %) VEXAS patients showed an inflammatory orbital/ocular involvement during their clinical history...
March 18, 2024: Seminars in Arthritis and Rheumatism
#9
JOURNAL ARTICLE
Muhammad Abumanhal, Igal Leibovitch, Michael Zisapel, Tali Eviatar, Yonatan Edel, Ran Ben Cnaan
BACKGROUND: VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a hematoinflammatory disease that typically affects adults. It results from a somatic mutation of the E1 ubiquitin conjugating enzyme encoded by the UBA1 gene. VEXAS is frequently accompanied by myelodysplastic syndrome (MDS). The purpose of this study is to describe the ocular and orbital manifestations of VEXAS patients in a case series in our medical centre. METHODS: A retrospective chart review was performed for all patients who were diagnosed with VEXAS syndrome in a tertiary medical centre over two years...
March 28, 2024: Eye
#10
Aashna Doshi, Mauli Shah, Bhaskar Srinivasan, Parthopratim Dutta Majumder
A 42-year-old male presented initially with conjunctivitis and was treated with topical medical medications without any improvement. He developed ocular pain subsequently and further examination revealed lid edema, conjunctival hyperemia with chemosis, matting of lashes with yellowish discharge, and deeper episcleral congestion which did not blanch with topical vasoconstrictor. Subsequent laboratory investigation revealed positive cytoplasmic-antineutrophil cytoplasmic antibody (Anti-PR 3 antibody). He continued to develop recurrences and finally responded to oral azathioprine...
2024: Oman Journal of Ophthalmology
#11
REVIEW
Dimitrios Kalogeropoulos, Farid Afshar, Chris Kalogeropoulos, Georgios Vartholomatos, Andrew John Lotery
Acute retinal necrosis (ARN) is a rare but severe ophthalmic pathology defined by panuveitis, retinal necrosis, and high rates of retinal detachment. ARN may lead to poor visual outcomes even if promptly diagnosed and treated. ARN may present with a wide spectrum of clinical findings compatible with panuveitis including anterior uveitis, scleritis, vitritis, necrotizing retinitis, occlusive vasculitis, and optic disc edema. The American Uveitis Society introduced clinical criteria in 1994 for the diagnosis of ARN, while more recent criteria have been proposed by the Standardization of Uveitis Nomenclature (SUN) Working Group and the Japanese ARN Study Group...
March 22, 2024: Eye
#12
JOURNAL ARTICLE
Kang Xue, Fengxi Meng, Hui Ren, Han Yue, Lin Jonathan He, Ruiqi Ma, Xintong Lin, Jiang Qian, Jie Guo
AIMS: To describe the clinical features, multimodal imaging, treatments and natural course of acute spontaneous vortex vein occlusion. METHODS: Clinical data were collected on nine patients with acute vortex vein occlusion. The symptoms and signs, multimodal imaging, treatments and follow-up results were summarised. RESULTS: Six patients (66.7%) were men and three (33.3%) were women. The mean age was 47.8±15.4 years. Patients were initially misdiagnosed as having choroidal tumour (66...
March 18, 2024: British Journal of Ophthalmology
#13
REVIEW
Terence Ang, Viraj Chaggar, Jessica Y Tong, Dinesh Selva
We performed a comprehensive systematic review to identify medication-associated orbital inflammation and to characterize its clinico-radiological features. We reviewed English-language articles describing medication-associated orbital inflammation (i.e., orbital myositis, dacryoadenitis and orbital fat) published to June 2023. Isolated inflammation of the intraocular structures or globe alone (i.e. uveitis), scleritis, optic neuritis and peri-neuritis) were excluded. In medication-associated orbital inflammation, the extraocular muscles are preferentially affected, occurring in isolation or in combination with other orbital and/or intraocular structures...
March 13, 2024: Survey of Ophthalmology
#14
JOURNAL ARTICLE
Irmak Karaca, Elaine M Tran, SungWho Park, Albert Bromeo, Hassan Khojasteh, Anh Ngọc Tram Tran, Negin Yavari, Amir Akhavanrezayat, Cigdem Yasar, Gunay Uludag Kirimli, Ngoc Tuong Trong Than, Muhammad Hassan, Christopher Or, Hashem Ghoraba, Diana V Do, Quan Dong Nguyen
BACKGROUND: Ocular inflammatory diseases, including scleritis and uveitis, have been widely treated with immunomodulatory therapies (IMTs) as a steroid-sparing approach. Such strategy includes conventional therapies (antimetabolites, alkylating agents, and calcineurin inhibitors) as well as biologic agents like adalimumab, infliximab, rituximab, and tocilizumab. Cyclophosphamide (CP) is an alkylating agent and mainly inhibits the functioning of both T and B cells. Though known to have potential adverse events, including bone marrow suppression, hemorrhagic cystitis, and sterility, CP has been shown to be efficacious, especially in recalcitrant cases and when used intravenous (IV) for a limited period...
March 11, 2024: Journal of Ophthalmic Inflammation and Infection
#15
Yoshihiro Nakagawa, Takahiro Suzuki, Yasuyuki Suzuki
Surgically induced necrotizing scleritis (SINS) is a rare inflammatory disease of the sclera that occurs following ocular surgery, specifically pterygium surgery and scleral buckling. Here, we report a case of SINS in a 78-year-old female patient after segmental scleral buckling for rhegmatogenous retinal detachment. The retina was restored after scleral buckling, and the postoperative course was uneventful. However, the patient developed ocular discharge and conjunctival hyperemia, indicating infection, after two months...
February 2024: Curēus
#16
JOURNAL ARTICLE
Ankush Kawali, Aayesha Khanum, Sai Bhakti Mishra, Srinivasan Sanjay, Padmamalini Mahendradas, Rohit Shetty
PURPOSE: To compare various ocular thermography parameters in posterior scleritis (PS), choroiditis (choroidal granuloma [CG], Vogt-Koyanagi-Harada [VKH] syndrome), central serous chorioretinopathy (CSCR), and healthy controls. METHODS: This retrospective, observational, comparative study evaluated cases undergoing ocular thermography between April 2017 and October 2023. The study groups included cases of PS, CG, and VKH, while the control group comprised CSCR cases and healthy individuals...
March 8, 2024: Indian Journal of Ophthalmology
#17
JOURNAL ARTICLE
Laura Butler, Oren Tomkins-Netzer, Or Reiser, Rachael L Niederer
Scleritis, an inflammatory disease of the eye affecting scleral tissue, presents unique challenges in the older adult population. Unlike their younger counterparts, older individuals manifest a distinct spectrum of the disease with different underlying etiologies, co-morbidities, altered immune function, and an increased risk of systemic side effects from medication choices. Addressing these complexities necessitates a comprehensive and multidisciplinary approach. Treatment of choice will depend on any underlying cause but generally involves non-steroidal anti-inflammatory drugs, systemic or local corticosteroids, and potentially disease-modifying anti-rheumatic drugs...
March 5, 2024: Drugs & Aging
#18
JOURNAL ARTICLE
Parthopratim Dutta Majumder, Sharanya Abraham, Sridharan Sudharshan, Mahesh Janarthanan, Athimalaipet V Ramanan
PURPOSE: This study analyzes the efficacy and safety of tofacitinib in pediatric patients presenting with treatment-resistant uveitis and scleritis. METHOD: Retrospective Chart Review. RESULT: Nine children diagnosed with uveitis and one with scleritis received oral tofacitinib treatment. The median age of these patients was 9 years, with bilateral involvement observed in nine of them. Juvenile idiopathic arthritis was the most identifiable cause of uveitis, with anterior uveitis (50%) being the most frequent subtype of inflammation among these children...
March 5, 2024: Ocular Immunology and Inflammation
#19
JOURNAL ARTICLE
Mahdi Sharifzadeh Kermani, Maryam Farsi, Ali Sharifi, Mahsa Sardarinia, Amin Zand
We herein present a rare case of acute central serous chorioretinopathy (CSC) associated with nonspecific orbital inflammation (NSOI). A 38-year-old woman presented with a 3-day history of ocular pain, reduced vision, periorbital swelling, proptosis, conjunctival chemosis, and restricted eye movements. Optical coherence tomography of the affected eye confirmed signs of CSC. Additionally, a computed tomography scan revealed enlargement of intraconal soft tissues and the lacrimal gland. Ocular ultrasonography detected posterior sclera thickening, indicating posterior scleritis...
March 2024: Journal of International Medical Research
#20
JOURNAL ARTICLE
Sadhana Sharma, Ranju Kharel, Sanket Parajuli, Ruchi Shrestha, Shradha Tiwari, Himang Singh Maskey
PURPOSE: This study aims to elucidate the demographic characteristics, clinical features, diagnostic approaches, and medical management of patients with ocular syphilis, known as 'the great masquerader,' at a tertiary eye care center in Nepal. METHODS: We conducted a retrospective review involving 15 eyes from ten patients with ocular syphilis treated at a uveitis referral center between 2020 and 2022. Lumbar puncture was performed if neurosyphilis was suspected...
March 1, 2024: International Journal of STD & AIDS
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