Jianqiong Huang, Yanyan Lou, Jiyong Liu, Philippe Bulet, Chuping Cai, Kaiyu Ma, Renjie Jiao, Jules A Hoffmann, Samuel Liégeois, Zi Li, Dominique Ferrandon
The Drosophila systemic immune response against many Gram-positive bacteria and fungi is mediated by the Toll pathway. How Toll-regulated effectors actually fulfill this role remains poorly understood as the known Toll-regulated antimicrobial peptide (AMP) genes are active only against filamentous fungi and not against Gram-positive bacteria or yeasts. Besides AMPs, two families of peptides secreted in response to infectious stimuli that activate the Toll pathway have been identified, namely Bomanins and peptides derived from a polyprotein precursor known as Baramicin A (BaraA)...
March 21, 2023: Proceedings of the National Academy of Sciences of the United States of America