Antonina V Kurtova, Melanie Heinlein, Simon Haas, Lars Velten, Gerrit J P Dijkgraaf, Elaine E Storm, Noelyn M Kljavin, Soufiane Boumahdi, Patricia Himmels, Aurelie Herault, Andrew G Mancini, Hartmut Koeppen, Monique Dail, Mark Yan, Jianhuan Zhang, Ute Koch, Freddy Radtke, Zora Modrusan, Ciara Metcalfe, Robert Piskol, Frederic J de Sauvage
Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and locally by various niche-confined factors. R-spondin 3 (RSPO3) is one of the most potent enhancers of Wnt signaling and its expression is usually restricted to the stem cell niche where it provides localized enhancement of Wnt signaling to regulate stem cell expansion and differentiation. Disruption of this niche-confined expression can disturb proper tissue organization and lead to cancers...
August 1, 2022: Blood Advances