Weiyi Zhang, Hongping Liang
BACKGROUND: Preeclampsia (PE) has adverse effects on pregnant women, fetuses, and newborns [1], and accounts for 3%-10% of pregnancy-related diseases globally. OBJECTIVE: This study aimed to screen a series of prenatal markers (pregnancy-associated plasma protein [PAPP-A], β-human chorionic gonadotropin [β-hCG], alpha fetoprotein [AFP], and estriol [uE3]) to establish a risk model and evaluate the diagnostic values of the markers for predicting PE. METHODS: Sixty-five pregnant women were enrolled in this study...
November 17, 2022: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Mariyan J Jeyarajah, Gargi Jaju Bhattad, Rachel D Kelly, Kelly J Baines, Adam Jaremek, Fei-Hung P Yang, Hiroaki Okae, Takahiro Arima, Vanessa Dumeaux, Stephen J Renaud
Remodeling of the uterine vasculature by invasive extravillous trophoblasts (EVTs) is a critical aspect of human placentation. Insufficient EVT invasion can lead to severe obstetrical complications like preeclampsia, intrauterine growth restriction, and preterm birth. Glial cells missing-1 (GCM1) is a transcription factor that is crucial for proper placentation in mice, and is highly expressed in human syncytiotrophoblast (ST) and EVTs. GCM1 is classically considered a master regulator of ST formation, but little is known about its contribution to the development and function of EVTs...
December 6, 2022: Proceedings of the National Academy of Sciences of the United States of America
Danielle S Roubinov, Elissa S Epel, Michael Coccia, Kimberly Coleman-Phox, Cassandra Vieten, Nancy E Adler, Barbara Laraia, Nicole R Bush
OBJECTIVE: Depression is a public health crisis, and scalable, affordable interventions are needed. Although many psychosocial interventions are effective, there is little research investigating their sustained, long-term influence on well-being. The purpose of this study was to examine whether a prenatal mindfulness intervention with demonstrated benefit for women's depressive symptoms during the early postpartum period would exert effects through 8 years. METHOD: The sample of 162 lower income women was racially and ethnically diverse...
November 28, 2022: Journal of Consulting and Clinical Psychology
Senait Tadesse, Ariaya Hymete, Marya Lieberman, Seifu Hagos Gebreyesus, Ayenew Ashenef
BACKGROUND: Iodine is one of the crucial micronutrients needed by the human body, and is vitally important during pregnancy. This study aimed to determine the relationship between the iodine status of pregnant women and their knowledge, and practices regarding iodized salt. All participants were enrolled in the Butajira nutrition, mental health and pregnancy (BUNMAP) cohort, Butajira, Ethiopia in February-May, 2019. METHODS: In this cross-sectional study, 152 pregnant women without hypertension or known thyroid disease before or during pregnancy were randomly selected from the BUNMAP mother to child cohort (n = 832)...
2022: PloS One
Claartje M Bruin, Silvia M Lobmaier, Wessel Ganzevoort, Alexander Müller, Hans Wolf
OBJECTIVES: To compare short term variation (STV) and phase rectified signal averaging (PRSA) and their association with fetal outcome in early onset fetal growth restriction (FGR). METHODS: Data were used from a retrospective cohort study of women who were admitted for FGR and/or pre-eclampsia and who were delivered by pre-labor Cesarean section or had a fetal death before 32 weeks' gestation. Computerized cardiotocography (cCTG) registrations of the 5 days before delivery or fetal death were used for calculation of STV and PRSA...
November 29, 2022: Journal of Perinatal Medicine
Asma Ahmed, Laura C Rosella, Maryam Oskoui, Tristan Watson, Seungmi Yang
IMPORTANCE: Although maternal unintentional injury during pregnancy has shown negative impacts on the mother and fetus, the evidence on its long-term associations with children's neurodevelopment is limited. OBJECTIVE: To examine the association between maternal unintentional injury and cerebral palsy (CP) in offspring. DESIGN, SETTING, AND PARTICIPANTS: This was a population-based, longitudinal, cohort study of all in-hospital live births born between April 1, 2002, and March 31, 2017, in a publicly funded health care system setting of Ontario, Canada...
November 28, 2022: JAMA Pediatrics
Ren-Ren Chen, Jia Wang, Min Zhang, Qiao-Qiao Kong, Guang-Yi Sun, Chun-Hui Jin, Ming-Jiu Luo, Jing-He Tan
Studies suggest that psychological stress on women can impair their reproduction and that postovulatory oocyte aging (POA) might increase the risk of early pregnancy loss and affect offspring's reproductive fitness and longevity. However, whether psychological stress during oocyte development would facilitate POA is unknown but worth exploring to understand the mechanisms by which psychological stress and POA damage oocytes. This study observed effects of female restraint stress during oocyte development (FRSOD) on oocyte resistance to POA...
November 26, 2022: Aging
Zeyan Liew, Haoran Zhuo
No abstract text is available yet for this article.
November 28, 2022: JAMA Pediatrics
Capucine Rossi, Jean-Pierre Siffroi, Léa Ruosso, Eli Rogers, Michael Becker, Nino Guy Cassuto, Laura Prat-Ellenberg, Alexandre Rouen
INTRODUCTION: Complex chromosomal rearrangements (CCRs) involve two or more chromosomes and at least three breakpoints. Due to their complexity, they are associated with a high number of unbalanced gametes, whose fertilization is often incompatible with viable fetal development. Preimplantation genetic diagnosis (PGD) is usually offered to those patients and typically shows modest results considering the high number of unbalanced embryos. We previously showed that a sperm selection process using the hypo-osmotic swelling test (HOST) allows for an 83% reduction in the proportion of unbalanced spermatozoa (US) in male rearrangements carriers...
November 28, 2022: Journal of Assisted Reproduction and Genetics
Jennifer Karlin, Caroline C Hodge
This essay is an ethnographic account of a volunteer, anonymous hotline of physicians and advanced practice providers who offer medical advice and guidance to those who are taking medications on their own to end their pregnancies. Attending to the phenomenology of caring on the Hotline reveals a new form of medical expertise at play, which we call "care with nothing in the way." By operating outside the State's scrutiny of abortion provision, the Hotline offers its volunteers a way to practice abortion care that aligns with their professional and political commitments and that distances them from the direct harm they see caused by the political, financial, and bureaucratic constraints of their clinical work...
November 28, 2022: Culture, Medicine and Psychiatry
Nana Li, Zhiwei Xue, Hongmei Xu, Ping Yang, Ke Wang, Lu Li, Hong Kang, Meixian Wang, Ying Deng, Xiaohong Li, Yanping Wang, Jun Zhu, Ping Yu, Shu Zhou
PURPOSE: To evaluate the impact of Nausea and Vomiting in Pregnancy (NVP) on the risk of Preterm Birth (PTB) and Low Birth Weight (LBW), and explore the effect of genetic polymorphisms on the severity of NVP. METHODS: A prospective study was conducted. Participants' experience of NVP prior to 12 gestational weeks were evaluated by a Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) scale. 11 Single Nucleotide Polymorphisms (SNPs) loci located in growth differentiation factor 15 (GDF15) and leucine-rich repeat containing 25 (LRRC25) gene of chr19p13...
November 28, 2022: Archives of Gynecology and Obstetrics
Julie M Petersen, Samantha E Parker, Kimberly A Dukes, Jennifer A Hutcheon, Katherine A Ahrens, Martha M Werler
BACKGROUND: Placental abnormalities have been described in clinical convenience samples, with predominately adverse outcomes. Few studies have described placental patterns in unselected samples. OBJECTIVE: We aimed to investigate associations between co-occurring placental features and adverse pregnancy outcomes in a prospective cohort of singletons. METHODS: Data were from the Safe Passage study (U.S. and South Africa, 2007-2015). Before 24 weeks' gestation, participants were randomly invited to donate placental tissue at delivery for blinded, standardised pathological examination...
November 28, 2022: Paediatric and Perinatal Epidemiology
Steffen Ernesto Kristensen, Charlotte Kvist Ekelund, Puk Sandager, Finn Stener Jørgensen, Eva Hoseth, Lene Sperling, Sedrah Butt Balaganeshan, Tina Duelund Hjortshøj, Kasper Gadsbøll, Alan Wright, David Wright, Andrew McLennan, Karin Sundberg, Olav Bjørn Petersen
BACKGROUND: Twin pregnancies carry a higher risk of congenital and structural malformations, and pregnancy complications including miscarriage, stillbirth, and intrauterine fetal death, compared with singleton pregnancies. Carrying a fetus with severe malformations or abnormal karyotype places the remaining healthy fetus at an even higher risk of adverse outcome and pregnancy complications. Maternal medical conditions or complicated obstetrical history could, in combination with twin pregnancy, cause increased risks for both the woman and the fetuses...
October 29, 2022: American Journal of Obstetrics and Gynecology
Charlotte E van Dijk, Sofie H Breuking, Sophie Jansen, Jacqueline C E J M Limpens, Brenda M Kazemier, Eva Pajkrt
OBJECTIVE: Given that many studies report on a limited spectrum of adverse events of transvaginal cervical cerclage for preventing preterm birth, but are not powered to draw conclusions about its safety, the objective of this study was to conduct a systematic review with pooled risk analyses of perioperative complications and compare characteristics on the basis of indication for cerclage in singleton pregnancies. DATA SOURCES: Ovid MEDLINE, Ovid Embase, Web of Science, the Cochrane Central Register of Controlled Trials (CENTRAL), and the prospective trial registers ClinicalTrials...
October 28, 2022: American Journal of Obstetrics and Gynecology
Tamara Guénoun, Aziz Essadek, Christophe Clesse, Marion Mauran-Mignorat, Estelle Veyron-Lacroix, Albert Ciccone, Barbara Smaniotto
Background: This qualitative systematic review provides an overview of existing studies on the desire for parenthood of people with intellectual disabilities. Method: The scientific studies were identified following the Prisma protocol on 18 databases using keywords relating to sexuality and parenting. Results: Sixteen studies have been included and three categories identified: the obstacles and motivations to becoming a parent; parents' decision making during pregnancy; and the social construction of a parental identity...
November 28, 2022: Journal of Intellectual Disabilities: JOID
Claire L Stevens-Haas, Mary Christine Livergood, Juliana Perez Botero, Jennifer J McIntosh
Literature regarding the management of thrombus refractory to first-line treatment in the setting of pregnancy is limited, and management is made even more complicated in the context of thrombophilia. This case reviews the management of a patient with antithrombin deficiency who developed a massive thrombus during pregnancy, which was complicated by May-Thurner syndrome, lack of improvement with heparin, and preterm labor. The patient received multidisciplinary care throughout the pregnancy. At 35 weeks, anticoagulation was paused as she underwent induction of labor and delivery followed by postpartum placement of inferior vena cava filter and restarting heparin...
November 25, 2022: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Katharine A Smith, Louise M Howard, Simone N Vigod, Armando D'Agostino, Andrea Cipriani
The COVID-19 pandemic and its aftermath have increased pre-existing inequalities and risk factors for mental disorders in general, but perinatal mental disorders are of particular concern. They are already underdiagnosed and undertreated, and this has been magnified by the pandemic. Access to services (both psychiatric and obstetric) has been reduced, and in-person contact has been restricted because of the increased risks. Rates of perinatal anxiety and depressive symptoms have increased. In the face of these challenges, clear guidance in perinatal mental health is needed for patients and clinicians...
November 28, 2022: Australian and New Zealand Journal of Psychiatry
Matias Vaajala, Ilari Kuitunen, Lauri Nyrhi, Ville Ponkilainen, Tuomas T Huttunen, Ville M Mattila
BACKGROUND AND PURPOSE:  Smoking weakens bone health and increases the risk of fractures. We investigated the incidence of fractures in smoking, fertile-aged women and compared it with that of non-smoking, fertile-aged women using data from nationwide registers. PATIENTS AND METHODS:  We conducted a retrospective register-based nationwide cohort study from 1998 to 2018. We identified all women smoking during pregnancy from the Medical Birth Register and compared these with non-smokers...
November 25, 2022: Acta Orthopaedica
Emily S Mann, Dana Berkowitz
The United States is experiencing a demographic transition toward older motherhood. Biomedicine classifies pregnancies among all women of advanced maternal age (AMA) as high-risk; paradoxically, women having first births at AMA are typically economically and racially privileged, which can reduce the risk of risks. This article examines the implications of the biomedicalization of AMA for first-time mothers, age 35 and older, using qualitative interviews. We find participants had substantial cultural health capital, which informed their critiques of AMA and the medical model of birth...
November 28, 2022: Journal of Health and Social Behavior
Bonnie R Boyle, Andrew D Ablett, Christiantus Ochi, Jemma Hudson, Laura Watson, Diayne Rauh, Alison Avenell
BACKGROUND: Weight loss could improve fertility, perhaps by reducing insulin resistance. OBJECTIVES: To assess the effect of weight loss interventions on fertility in women with obesity not recruited because of known infertility. SEARCH STRATEGY: Three databases during 1966-2020, trial registry. SELECTION CRITERIA: Randomized controlled trials (RCTs) with a follow-up of 1 year or more, with a mean cohort BMI of 30 kg/m2 or above...
November 28, 2022: International Journal of Gynaecology and Obstetrics
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.