Esin Kasap, Ceren Saglam, Raziye Torun, Can Turkler, Esra Bahar Gur, Ebru Sahin Güleç, Mehmet Bora Bozgeyik
PURPOSE: This study compared fetal thymic-thoracic ratios and fetal thymus transverse diameter measurements in pregnant women with Hashimoto's thyroiditis (HT) and non-immune hypothyroidism. METHODS: The study included a total of 141 pregnant women in three groups: 41 with HT, 50 with non-immune hypothyroidism, and 50 healthy individuals. Fetal thymus transverse diameter and thymic-thoracic ratio were compared between these groups. RESULTS: The mean fetal thymic-thoracic ratio was greater in pregnant women with HT than in the healthy controls (p = 0...
July 13, 2024: Journal of Clinical Ultrasound: JCU
Sarah Long, Peter O'Leary, Richard Norman, Jan E Dickinson
INTRODUCTION: Ongoing advances in genetic technology may soon provide prenatal screening for multiple genetic conditions. AIMS: The aims were to investigate what prenatal screening test characteristics women prioritise and their willingness to pay for these tests. METHODS: We designed an online survey incorporating a series of discrete choice scenarios. Dimensions and levels were selected based on existing prenatal tests and a hypothetical prenatal test that could non-invasively detect multiple genetic disorders in pregnancy...
July 13, 2024: Australian & New Zealand Journal of Obstetrics & Gynaecology
Xi Wang, Corbin A Shields, Deanna Thompson, Jie McKay, Rachel Wilson, Marcus K Robbins, Hannah Glenn, Molly Fontenot, Jan M Williams, Denise C Cornelius
PROBLEM: Preeclampsia (PE) is a hypertensive pregnancy disorder that is a leading cause of maternal and fetal morbidity and mortality characterized by maternal vascular dysfunction, oxidative stress, chronic immune activation, and excessive inflammation. No cure exists beyond delivery of the fetal-placental unit and the mechanisms driving pathophysiology are not fully understood. However, aberrant immune responses have been extensively characterized in clinical studies and shown to mediate PE pathophysiology in animal studies...
July 2024: American Journal of Reproductive Immunology: AJRI
Marta Heras, Maria Alonso-Espias, Octavio Arencibia, Lucas Minig, Lola Marti, Maria Dolores Diestro, Juan Cespedes, Isabel Niguez, Blanca Gil-Ibañez, Berta Diaz-Feijoo, Antoni Llueca, Claudia Rosado, Sara Iacoponi, Carlos Lopez de la Manzanara, Sara Morales, Maria Jose Fernandez-Galguera, Ana Cano, Mikel Gorostidi, Ignacio Zapardiel
BACKGROUND: to prove the effectivity of fertility-sparing procedures in early-stage ovarian cancer by assessing pregnancy rates and obstetrical outcomes. METHODS: we performed a retrospective multicenter study among 55 Spanish hospitals, collecting patients from 18 to 40 years old with diagnosis of early-stage ovarian cancer, epithelial (EOC) or non-epithelial (non-EOC), from January 2010 to December 2019. Data on the use of assisted reproductive techniques, pregnancy attempts and obstetrical outcomes were collected...
July 3, 2024: Diagnostics
Alyssa Kwok
Patients with rheumatic diseases frequently operate with incomplete or incorrect information while planning for and experiencing pregnancy, often due to variability in provider care and knowledge. Risk assessment at each stage of pregnancy-pre-conception, during pregnancy, and postpartum-is focused on reducing maternal and neonatal complications. This review aims to compile updated, evidence-based guidance on how to minimize risk factors contributing to adverse pregnancy outcomes (APOs). Mitigation of known causes of infertility, appropriate testing and monitoring, achieving low disease activity on pregnancy-safe disease-modifying antirheumatic drugs (DMARDs) prior to conception, controlling hypertension (a frequent comorbidity among patients with certain rheumatic diseases), and the use of appropriate adjunctive medications (such as low-dose aspirin when preeclampsia risk is high) can optimize fertility and prevent adverse maternal and neonatal outcomes...
July 2, 2024: Diagnostics
Flavius George Socol, Elena Silvia Bernad, Marius Craina, Simona-Alina Abu-Awwad, Brenda-Cristiana Bernad, Ioana Denisa Socol, Simona Sorina Farcas, Ahmed Abu-Awwad, Nicoleta Ioana Andreescu
BACKGROUND: Preeclampsia (PE) and eclampsia (E) are severe pregnancy complications with significant maternal and neonatal health impacts. This study explores the association of the rs5707 polymorphism in the renin-angiotensin system (RAS) with PE/E and related neonatal outcomes. MATERIALS AND METHODS: We conducted a cross-sectional study involving 400 mother-newborn dyads at the "Pius Brinzeu" Emergency Clinical Hospital Timisoara. Participants were divided into a control group (254 normotensive women) and a PE/E group (146 women with PE/E)...
June 27, 2024: Diagnostics
Thenral Socrates, Céline Wenker, Annina Vischer, Christina Schumacher, Fiona Pugin, Andreas Schötzau, Michael Mayr, Irene Hösli, Beatrice Mosimann, Olav Lapaire, Thilo Burkard
Postpartum hypertension (PPHT) is hypertension that persists or develops after delivery and is a frequent cause of readmission, affecting 10% of pregnancies. This interim analysis aims to describe the cohort and to determine the feasibility and acceptance of a home-based telemonitoring management strategy (HBTMS) in PPHT patients. Enrollment at the University Hospital Basel began during the 2020 SARS-CoV-2 pandemic. Maternity-ward patients were screened for preexisting hypertension, hypertensive disorders of pregnancy, and de novo PPHT...
June 25, 2024: Diagnostics
Daniela Navarro, Ani Gasparyan, Francisco Navarrete, Jorge Manzanares
This study establishes a fetal cannabinoid syndrome model to evaluate the effects of high doses of dronabinol (synthetic THC) during pregnancy and lactation on behavioral and brain changes in male and female progeny and their susceptibility to alcohol consumption. Female C57BL/6J mice received dronabinol (10 mg/kg/12 h, p.o.) from gestational day 5 to postnatal day 21. On the weaning day, the offspring were separated by sex, and on postnatal day 60, behavioral and neurobiological changes were analyzed. Mice exposed to dronabinol exhibited increased anxiogenic and depressive-like behaviors and cognitive impairment...
July 7, 2024: International Journal of Molecular Sciences
Minja Derikonjic, Marija Saric Matutinovic, Sandra Vladimirov Sopic, Tamara Antonic, Aleksandra Stefanovic, Jelena Vekic, Daniela Ardalic, Milica Miljkovic-Trailovic, Marko Stankovic, Tamara Gojkovic, Jasmina Ivanisevic, Jelena Munjas, Snezana Jovicic, Zeljko Mikovic, Aleksandra Zeljkovic
Obesity is an important risk factor for the development of pregnancy complications. We investigated the effects of pregestational overweight and obesity on maternal lipidome during pregnancy and on newborns' characteristics. The study encompassed 131 pregnant women, 99 with pre-pregnancy body mass index (BMI) < 25 kg/m2 and 32 with BMI ≥ 25 kg/m2 . Maternal lipid status parameters, plasma markers of cholesterol synthesis and absorption and sphingolipids were determined in each trimester. Data on neonatal height, weight and APGAR scores were assessed...
July 7, 2024: International Journal of Molecular Sciences
Stefánia Gitta, Éva Szabó, Alexandra Sulc, Péter Czétány, Gábor Máté, András Balló, Tímea Csabai, Árpád Szántó, László Márk
The receptive phase of the uterus is marked by structural and functional maturation of the endometrium. During this limited time span, the blastocyst competency is superimposed on the receptive endometrium. It is a well-known fact that lipid signalling in early-stage pregnancy has a crucial role in successful embryogenesis. In our study, CD-1 mouse uteri after normal and in vitro fertilization (IVF) were investigated at 6.5, 8.5, and 10.5 days of pregnancy. Matrix-assisted laser desorption/ionization time-of-flight imaging mass spectrometry and liquid chromatography coupled tandem mass spectrometry were used for identification of phosphatidylcholine (PC) lipid structures...
July 6, 2024: International Journal of Molecular Sciences
I-Chun Lin, Kay L H Wu, Hsin-Hsin Cheng, Ching-Chang Tsai, Hong-Ren Yu, Te-Yao Hsu, You-Lin Tain, Li-Tung Huang, Yun-Ju Lai
We hypothesized and investigated whether prenatal exposure to preeclampsia (PE) would simultaneously affect perinatal cardiovascular features and angiotensin system expressions. This prospective study was composed of mother-neonate dyads with (n = 49) and without maternal preeclampsia (n = 48) in a single tertiary medical center. The neonates exposed to PE had significantly larger relative sizes for the left and right coronary arteries and a higher cord plasma level of aminopeptidase-N, which positively correlated with the maternal diastolic blood pressures and determined the relative sizes of the left and right coronary arteries, whereas the encoding aminopeptidase-N ( ANPEP ) mRNA level in the PE cord blood leukocytes was significantly decreased, positively correlated with the neonatal systolic blood pressures (SBPs), and negatively correlated with the cord plasma-induced endothelial vascular cell adhesion molecule-1 mRNA levels...
July 6, 2024: International Journal of Molecular Sciences
Lindsey Eileen, Maria Peterson
Maternal obesity, caused by diets rich in fats and sugars during pregnancy, can predispose offspring to metabolic diseases such as diabetes. We hypothesized that obesity during pregnancy leads to increased DNA methylation and reduced protein expression in factors regulating β-cell function and apoptosis. Female C57BL/6J mice were fed a high-fat diet (HFD; 42% fat content; n = 3) or a control diet (CON; 16% fat content; n = 3) for fourteen weeks before and during pregnancy. Offspring were euthanized at 8 weeks and pancreatic tissue was collected...
July 3, 2024: International Journal of Molecular Sciences
Yaqi Li, Hongpan Wu, Xiaosong Pei, Shuai Liu, Qiu Yan
Preeclampsia (PE) is a pregnancy-specific disorder associated with shallow invasion of the trophoblast cells and insufficient remodeling of the uterine spiral artery. Protein glycosylation plays an important role in trophoblast cell invasion. However, the glycobiological mechanism of PE has not been fully elucidated. In the current study, employing the Lectin array, we found that soybean agglutinin (SBA), which recognizes the terminal N-acetylgalactosamine α1,3-galactose (GalNAc α1,3 Gal) glycotype, was significantly increased in placental trophoblast cells from PE patients compared with third-trimester pregnant controls...
July 2, 2024: International Journal of Molecular Sciences
Dominik Franciszek Dłuski, Marek Cieśla, Dorota Darmochwał-Kolarz
Gestational diabetes mellitus (GDM) is an intolerance of carbohydrate of any degree, which appears for the first time or is diagnosed during pregnancy. The objective of this study is to assess the differences in circular RNA (circRNA) in a Polish pregnant population with and without GDM. A total of 62 pregnant women, 34 with GDM and 28 controls, were enrolled in the study. Total RNAs were extracted from plasma and reverse transcription to complementary DNA (cDNA) was performed. A panel covering 271 amplicons, targeting both linear and circular as well as negative control gene transcripts, was used...
June 27, 2024: International Journal of Molecular Sciences
Natasha Ivanova, Milena Atanasova, Dora Terzieva, Katerina Georgieva, Jana Tchekalarova
Prenatal stress (PNS), which alters the hypothalamic-pituitary-adrenal axis function in the offspring, predisposes to insulin resistance (IR) in later life and is associated with numerous disorders, including cognitive and memory impairments. At present, our main goal is to assess the effects of chronic piromelatine (Pir) administration, a melatonin analogue, on PNS-provoked IR in the periphery and the hippocampus in male and female offspring. Pregnant Sprague-Dawley rats were exposed to chronic stress (one short-term stressor on a daily basis and one long-term stressor on a nightly basis) from the first gestation week until birth...
June 27, 2024: International Journal of Molecular Sciences
Jessie R Maxwell, Shahani Noor, Nathaniel Pavlik, Dominique E Rodriguez, Lidia Enriquez Marquez, Jared DiDomenico, Sarah J Blossom, Ludmila N Bakhireva
The prevalence of prenatal alcohol exposure (PAE) is increasing, with evidence suggesting that PAE is linked to an increased risk of infections. PAE is hypothesized to affect the innate immune system, which identifies pathogens through pattern recognition receptors, of which toll-like receptors (TLRs) are key components. We hypothesized that light-to-moderate PAE would impair immune responses, as measured by a heightened response in cytokine levels following TLR stimulation. Umbilical cord samples (10 controls and 8 PAE) from a subset of the Ethanol, Neurodevelopment, Infant and Child Health Study-2 cohort were included...
June 27, 2024: International Journal of Molecular Sciences
Anna Maria Lavezzi, Riffat Mehboob, Francesco Piscioli, Teresa Pusiol
This study aimed to investigate, for the first time, the potential role of the gigantocellular nucleus, a component of the reticular formation, in the pathogenetic mechanism of Sudden Infant Death Syndrome (SIDS), an event frequently ascribed to failure to arouse from sleep. This research was motivated by previous experimental studies demonstrating the gigantocellular nucleus involvement in regulating the sleep-wake cycle. We analyzed the brains of 48 infants who died suddenly within the first 7 months of life, including 28 SIDS cases and 20 controls...
June 25, 2024: International Journal of Molecular Sciences
Karolina Wrońska, Maciej Hałasa, Małgorzata Szczuko
The process of thyroid autoimmunization develops against the background of genetic predispositions associated with class II human leukocyte antigens (HLA-DR), as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), protein tyrosine phosphatase non-receptor type 22 (PTPN22), and forkhead transcription box protein P3 (FOXP3). Environmental factors, such as vitamin D deficiency, Zn, Se, and Mg, as well as infections, chronic stress, pregnancy, smoking, alcohol, medications, intestinal dysbiosis, and malnutrition, also play an important role...
June 23, 2024: International Journal of Molecular Sciences
Šárka Kaňková, Daniela Dlouhá, Jana Ullmann, Marta Velíková, Josef Včelák, Martin Hill
The emotion of disgust protects individuals against pathogens, and it has been found to be elevated during pregnancy. Physiological mechanisms discussed in relation to these changes include immune markers and progesterone levels. This study aimed to assess the association between steroids and disgust sensitivity in pregnancy. Using a prospective longitudinal design, we analyzed blood serum steroid concentrations and measured disgust sensitivity via text-based questionnaires in a sample of 179 pregnant women during their first and third trimesters...
June 22, 2024: International Journal of Molecular Sciences
Francesca Gonnella, Fani Konstantinidou, Marisa Donato, Daniela Maria Pia Gatta, Alessia Peserico, Barbara Barboni, Liborio Stuppia, Warren B Nothnick, Valentina Gatta
Female infertility constitutes a growing health problem in developing countries and could be associated with several possible causes including reproductive disorders, congenital malformations, infections and hormonal dysfunction. Nonetheless, a series of additional factors can also negatively impact female fertility and are represented by chronic exposure to environmental pollutants, stress, unhealthy lifestyle choices such as cigarette smoking and, among others, obesity. Excess weight is associated with several chronic diseases, and growing evidence demonstrates that it can compromise reproductive physiology due to its influence on endometrial gene expression and receptivity...
June 22, 2024: International Journal of Molecular Sciences
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