Lirong Fu, Juanjuan Ren, Xiaoxia Lei, Yewei Wang, Xiaochang Chen, Rong Zhang, Qingyi Li, Xinyue Teng, Chaoyue Guo, Zenan Wu, Lingfang Yu, Dandan Wang, Yan Chen, Jinmei Qin, Aihua Yuan, Chen Zhang
BACKGROUND: Anhedonia, a core symptom of major depressive disorder (MDD), manifests in two forms: anticipatory and consummatory, reflecting a diminished capacity to anticipate or enjoy pleasurable activities. Prior studies suggest that brain-derived neurotrophic factor (BDNF) and interleukin-10 (IL-10) may play key roles in the emergence of anhedonia in MDD. The specific relationships between these biomarkers and the two forms of anhedonia remain unclear. This study investigated the potential links between BDNF, IL-10, and both forms of anhedonia in MDD patients...
May 1, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry