Evy Loomis-Goltl, Patrick Briley, Katelyn J Kotlarek
OBJECTIVE: To determine the association between prenatal care and cleft lip with or without cleft palate (CL ± P) and examine differences in newborn complications among infants diagnosed with CL ± P as a function of prenatal care. DESIGN: Population-based retrospective cohort study. SETTING: 2018 United States National Vital Statistics System-Natality component (NVSS-N) was used to examine nationwide birth certificate data...
January 30, 2023: Cleft Palate-craniofacial Journal
Philippa Tollow, Claire Hamlet, Fabio Zucchelli, Heidi Williamson, Diana Harcourt
Globally, COVID-19 has been shown to have had a wide ranging and significant impact on individuals' daily living, and physical and mental health. However, there are some groups of individuals who may encounter unique challenges with regards to COVID-19 and whose experiences have not been investigated thus far. Therefore, this study aimed to understand the experiences of adults with a facial visible difference in relation to COVID-19 and lockdown. Semi-structured interviews were conducted with 21 adults with a variety of facial visible differences (e...
January 26, 2023: Current Psychology
Karim Ahmed Sakran, Jiayi Yin, Renjie Yang, Khaled Alkebsi, Sadam Ahmed Elayah, Remsh Khaled Al-Rokhami, Mohammed Ali Holkom, Yingmeng Liu, Yan Wang, Chao Yang, Bing Shi, Hanyao Huang
OBJECTIVE: To evaluate the postoperative outcomes together with analyzing the associated influencing factors following a late cleft palate repair by the Sommerlad-Furlow modified technique (S-F). MATERIALS AND METHODS: In a retrospective cohort, 320 consecutive patients with cleft palate, who received S-F technique between 2011-2017, were reviewed. The patients were divided into three age groups, less than one year (143), one to two years (113), and greater than 2 years (64)...
January 27, 2023: Journal of Stomatology, Oral and Maxillofacial Surgery
Laura Katarine Félix de Andrade, Jeniffer de Cássia Rillo Dutka, Gabriela Zuin Ferreira, Maria Daniela Borro Pinto, Maria Inês Pegoraro-Krook
Introduction  Compensatory articulations are speech disorders due to the attempt of the individual with cleft palate/velopharyngeal dysfunction to generate intraoral pressure to produce high-pressure consonants. Speech therapy is the indicated intervention for their correction, and an intensive speech therapy meets the facilitating conditions for the correction of glottal stop articulation, which is the most common compensatory articulation. Objective  To investigate the influence of an intensive speech therapy program (ISTP) to correct glottal stop articulation in the speech of individuals with cleft palate...
January 2023: International Archives of Otorhinolaryngology
Abdalmoeen Almohammad, Basel Brad, Amer M Owayda
Objectives The current study aimed to evaluate the effectiveness of plasma skin regeneration (PSR) in the treatment of cleft lip scars in cleft lip patients.  Materials and methods Twenty patients, 10 females and 10 males, with a mean age of 19 years and who had a cleft lip scar, were included in the current study. All patients were treated with a plasma skin regeneration pen device in one treatment session. The thickness, relief, and pliability of the scars were assessed by external observers using a 10-point numeric rating scale (NRS)...
December 2022: Curēus
Vikram C Mathad, Julie M Liss, Kathy Chapman, Nancy Scherer, Visar Berisha
Spectro-temporal dynamics of consonant-vowel (CV) transition regions are considered to provide robust cues related to articulation. In this work, we propose an objective measure of precise articulation, dubbed the objective articulation measure (OAM), by analyzing the CV transitions segmented around vowel onsets. The OAM is derived based on the posteriors of a convolutional neural network pre-trained to classify between different consonants using CV regions as input. We demonstrate that the OAM is correlated with perceptual measures in a variety of contexts including (a) adult dysarthric speech, (b) the speech of children with cleft lip/palate, and (c) a database of accented English speech from native Mandarin and Spanish speakers...
2023: IEEE/ACM Transactions on Audio, Speech, and Language Processing
Franceska Vinjolli, Megi Zeqaj, Edi Dragusha, Arianna Malara, Carlotta Danesi, Giuseppina Laganà
BACKGROUND: To evaluate the prevalence and the distribution of dental anomalies in an Albanian orthodontic sample. METHODS: For this retrospective study, a sample of panoramic radiographs (PR) of n. 779 (456 F and 323 M, mean age of 15.1 ± 5.5 years) Albanian subjects with no genetic syndromes or craniofacial malformations (e.g., cleft lip/palate), history of extraction, trauma or previous orthodontic treatment drawn from the archives of the University Dental Clinic Our Lady of Good Counsel, was examined...
January 28, 2023: BMC Oral Health
Mary L Marazita
This chapter reviews the evidence of gene×environment interactions (G×E) in the etiology of orofacial cleft birth defects (OFCs), specifically cleft lip (CL), cleft palate (CP), and cleft lip with or without cleft palate (CL/P). We summarize the current state of our understanding of the genetic architecture of nonsyndromic OFCs and the evidence that maternal exposures during pregnancy influence risk of OFCs. Further, we present possible candidate gene pathways for these exposures including metabolism of folates, metabolism of retinoids, retinoic acid receptor signaling, aryl hydrocarbon receptor signaling, glucocorticoid receptor signaling, and biotransformation and transport...
2023: Current Topics in Developmental Biology
Edwin M Ongkosuwito, Mette A R Kuijpers
An orofacial cleft (OC) is a congenital cleft that may affect the lip, alveolus, hard and soft palate. An OC impacts the individuals' appearance, psychosocial well-being and causes functional problems including feeding, dentition, growth of jaws, hearing and speech. The treatment of an orofacial cleft usually reaches from birth until 22 years of age or later. To understand and listen in an objective manner, OC specific Patient reported Outcome (PRO) and experience (PRE) measures are imperative. In patients with OCs many shared decision making moments exist from birth until adulthood...
January 2023: Journal of Evidence-based Dental Practice
Mahamad Irfanulla Khan, Prashanth C S, Mohammed S Mustak, Sheikh Nizamuddin
Cleft lip and/or cleft palate (CL/P) is one of the most common congenital anomalies of the human face with a complex etiology involving multiple genetic and environmental factors. Several studies have shown the association of the paired box 7 ( PAX7 ) gene with CL/P in different populations worldwide. However, the current literature reveals no reported case-parent trio studies to evaluate the association between the PAX7 gene and the risk of nonsyndromic cleft lip and/or palate (NSCL/P) in the Indian population...
January 2023: Global medical genetics
Shishir Dhar, Anshul Sawhney, Megha Ralli
BACKGROUND: The hair transplantation has become widely popular aesthetic procedure. Hair transplantation being a relatively new field in maxillofacial surgery, several aspects raise issues and controversies. Follicular unit transplantation (FUT) and follicular unit extraction (FUE) are two commonly used and accepted techniques. Further, hair transplantation has been successfully used in correction of alopecia, cleft lip scars, post-burn or surgical scars, vitiligo and as an adjuvant to other maxillofacial procedures...
March 2023: Journal of Maxillofacial and Oral Surgery
Sarvin Sarmadi, Atefe Saffar Shahroudi, Farnoush Mohammadi, Ahmad Reza Shamshiri, Fatemeh Safari
OBJECTIVES: The ideal time for nasoalveolar molding (NAM) of infants with cleft lip and/or palate (CLP) is the first weeks after birth. The burden and responsibility that this method of treatment imposes on parents may result in incompliance. The coronavirus (COVID-19) pandemic and the redirection of health resources can make the situation worse. Therefore, this study evaluated the anxiety, complications, and incompliance of parents undergoing NAM during the COVID-19 pandemic. MATERIALS AND METHODS: Demographic data of 35 infants with CLP treated during the COVID-19 pandemic, compliance and level of anxiety of both parents in addition to their complications were reported...
January 26, 2023: Cleft Palate-craniofacial Journal
Arnaud Gleizal, Pierre Gagnieur, Stéphane Tringali, Nicolas Nimeskern, Maxime Fieux, Julie Chauvel-Picard
INTRODUCTION: The aim of this study was to determine the predisposing factors of this deafness after orthognathic surgery for a population with no history of cleft palate. MATERIAL AND METHODS: All patients with significant auditory symptoms after orthognathic surgery performed in the department of Craniomaxillofacial surgery in the Croix Rousse Hospital, Lyon, France, since 2012 were included in the study. The exclusion criterion was a history of cleft palate. Bone movements performed during orthognathic surgery were analyzed...
January 23, 2023: Journal of Stomatology, Oral and Maxillofacial Surgery
Cassandra Alighieri, Ymke Haeghebaert, Kim Bettens, Imke Kissel, Evelien D'haeseleer, Iris Meerschman, Rani Van Der Sanden, Kristiane Van Lierde
BACKGROUND AND AIMS: Individuals with speech disorders are often judged more negatively than peers without speech disorders. A limited number of studies examined the attitudes of adolescents toward peers with speech disorders due to a cleft lip with or without a cleft of the palate (CL ± P). Therefore, the aim of the present study was to investigate the attitudes of peers toward the speech of adolescents with CL ± P. METHOD: Seventy-eight typically developing adolescents (15-18 years, 26 boys, 52 girls) judged audio and audiovisual samples of two adolescents with CL ± P based on three attitude components, i...
January 12, 2023: International Journal of Pediatric Otorhinolaryngology
Aditi Verma, Lakshya Kumar, Veerendra Prasad, Akanksha Yadav
Although maxillofacial trauma is relatively common, it still presents a challenging management. Its management includes treatment of facial bone fractures, dentoalveolar trauma and soft tissue injuries as well as associated injuries. Plastic surgeons, maxillofacial surgeons and prosthodontists have an interest in the subject of maxillofacial injuries, particularly in the area of functional as well as aesthetical stomatognathic rehabilitation. Present case was a clinical scenario with maxillofacial trauma due to entanglement in agricultural equipment leading to fracture of palatal bone and fracture of mandible in symphysis region...
January 25, 2023: BMJ Case Reports
Inge Apon, Nikki van Leeuwen, Maarten J Koudstaal, Alexander C Allori, Carolyn R Rogers-Vizena, Eppo B Wolvius, Anne F Klassen, Sarah L Versnel
BACKGROUND: To ensure the feasibility of implementing PROMs in clinical practice, they must be continually appraised for undue burden placed on patients and clinicians and their usefulness for decision-making. This study assesses correlations between the CLEFT-Q psychosocial scales in the International Consortium for Health Outcomes Measurement Standard Set for cleft and explores their associations with patient characteristics and psychosocial care referral. METHODS: Spearman correlation coefficients were calculated for CLEFT-Q psychological function, social function, school function, face, speech function, and speech-related distress scales...
February 1, 2023: Plastic and Reconstructive Surgery
Anna R Carlson, Mychajlo S Kosyk, Zachary D Zapatero, Christopher L Kalmar, Jordan W Swanson, Oksana A Jackson, David W Low, Scott P Bartlett, Jesse A Taylor
BACKGROUND: Nasal airway obstruction is an increasingly recognized phenomenon in patients with cleft lip and/or palate and has the potential to significantly affect quality of life in this patient population. To date, the effect of secondary cleft rhinoplasty on cleft-related nasal airway obstruction has not been studied. METHODS: Patients undergoing secondary cleft rhinoplasty at the Children's Hospital of Philadelphia from 2015 to 2021 were identified. Preoperative and postoperative Nasal Obstruction Symptom Evaluation scores were recorded...
February 1, 2023: Plastic and Reconstructive Surgery
Graham Bourne, Brian Kinard
OBJECTIVE: Currently there is variation in perioperative care of orthognathic surgery patients and limited clinical practice guidelines. The current orthognathic surgery practice patterns among US academic OMFS training centers have not been described. The purpose of this study is to describe the practice patterns among US academic OMFS training centers. DESIGN: The study design is cross-sectional. Data was collected through a survey of the sample. SETTING: OMFS programs in the US...
January 24, 2023: Cleft Palate-craniofacial Journal
Haoshu Chi, Xinran Zhao, Lingyue Shen, Yiyun Liu, Ming Cai
OBJECTIVE: To determine the optimal time to apply a fractional CO2 laser for the treatment of postsecondary repair scars in patients with cleft lip. METHODS: Forty-two patients with linear scarring after cleft lip repair were recruited from November 2021 to October 2022. A single-blind, randomized, controlled cohort study was conducted to examine the impact of fractional CO2 laser treatment compared with conventional conservative treatment. Thirty patients started laser treatment at 1 month (n = 10), 3 months (n = 10), and 6 months (n = 10) postoperatively, and 12 patients were in the control group...
January 20, 2023: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
K Zheng, Q N Ye
Abnormally high concentrations of all-trans retinoic acid (atRA) induce cleft palate, which is accompanied by abnormal migration and proliferation of mouse embryonic palatal mesenchyme (MEPM) cells. Hormone-sensitive lipase (HSL) is involved in many embryonic development processes. The current study was designed to elucidate the mechanism of HSL in cleft palate induced by atRA. To establish a cleft palate model in Kunming mice, pregnant mice were administered atRA (70 mg/kg) by gavage at embryonic Day 10.5 (E10...
January 20, 2023: International Journal of Developmental Biology
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