James Yarmolinsky, Caroline L Relton, Artitaya Lophatananon, Kenneth Muir, Usha Menon, Aleksandra Gentry-Maharaj, Axel Walther, Jie Zheng, Peter Fasching, Wei Zheng, Woo Yin Ling, Sue K Park, Byoung-Gie Kim, Ji-Yeob Choi, Boyoung Park, George Davey Smith, Richard M Martin, Sarah J Lewis
BACKGROUND: Various risk factors have been associated with epithelial ovarian cancer risk in observational epidemiological studies. However, the causal nature of the risk factors reported, and thus their suitability as effective intervention targets, is unclear given the susceptibility of conventional observational designs to residual confounding and reverse causation. Mendelian randomization (MR) uses genetic variants as proxies for risk factors to strengthen causal inference in observational studies...
August 2019: PLoS Medicine