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JOURNAL ARTICLE
Marijana Matejic-Spasic, Sandra Lindstedt, Guillaume Lebreton, Omer Dzemali, Piotr Suwalski, Thierry Folliguet, Stephan Geidel, Robert J M Klautz, Christophe Baufreton, Ugolino Livi, Serdar Gunaydin, Efthymios N Deliargyris, Daniel Wendt, Matthias Thielmann
BACKGROUND: Extracorporeal blood purification has been widely used in intensive care medicine, nephrology, toxicology, and other fields. During the last decade, with the emergence of new adsorptive blood purification devices, hemoadsorption has been increasingly applied during CPB in cardiac surgery, for patients at different inflammatory risks, or for postoperative complications. Clinical evidence so far has not provided definite answers concerning this adjunctive treatment. The current systematic review aimed to critically assess the role of perioperative hemoadsorption in cardiac surgery, by summarizing the current knowledge in this clinical setting...
May 18, 2024: BMC Cardiovascular Disorders
#2
RANDOMIZED CONTROLLED TRIAL
Xiaoru Yu, JiaWei Lu, Wenchao Liu, Zhenbo Cheng, Gang Xiao
Passive translational acceleration (PTA) has been demonstrated to induce the stress response and regulation of autonomic balance in healthy individuals. Electrodermal activity (EDA) and heart rate variability (HRV) measurements are reliable indicators of the autonomic nervous system (ANS) and can be used to assess stress levels. The objective of this study was to investigate the potential of combining EDA and HRV measurements in assessing the physiological stress response induced by PTA. Fourteen healthy subjects were randomly assigned to two groups of equal size...
May 18, 2024: Scientific Reports
#3
JOURNAL ARTICLE
A Skvortsova, S H Meeuwis, S Derksen, K Kerkkänen, E Sutter, Evers Awm, D S Veldhuijzen
Negative expectations can increase pain sensitivity, leading to nocebo hyperalgesia. However, the physiological and psychological factors that predispose individuals to this phenomenon are still not well understood. The present study examined whether stress induced by a social stressor affects nocebo hyperalgesia, and whether this effect is mediated by self-reported and physiological stress responses. We recruited 52 healthy participants (15 men) who were randomly assigned to either the Trier Social Stress Test (TSST) or a control condition (a friendly version of the TSST)...
May 16, 2024: Biological Psychology
#4
JOURNAL ARTICLE
Jürgen Beck, Christian Fung, Daniel Strbian, Lukas Bütikofer, Werner J Z'Graggen, Matthias F Lang, Seraina Beyeler, Jan Gralla, Florian Ringel, Karl Schaller, Nikolaus Plesnila, Marcel Arnold, Werner Hacke, Peter Jüni, Alexander David Mendelow, Christian Stapf, Rustam Al-Shahi Salman, Jenny Bressan, Stefanie Lerch, Arsany Hakim, Nicolas Martinez-Majander, Anna Piippo-Karjalainen, Peter Vajkoczy, Stefan Wolf, Gerrit A Schubert, Anke Höllig, Michael Veldeman, Roland Roelz, Andreas Gruber, Philip Rauch, Dorothee Mielke, Veit Rohde, Thomas Kerz, Eberhard Uhl, Enea Thanasi, Hagen B Huttner, Bernd Kallmünzer, L Jaap Kappelle, Wolfgang Deinsberger, Christian Roth, Robin Lemmens, Jan Leppert, Jose L Sanmillan, Jonathan M Coutinho, Katharina A M Hackenberg, Gernot Reimann, Mikael Mazighi, Claudio L A Bassetti, Heinrich P Mattle, Andreas Raabe, Urs Fischer
BACKGROUND: It is unknown whether decompressive craniectomy improves clinical outcome for people with spontaneous severe deep intracerebral haemorrhage. The SWITCH trial aimed to assess whether decompressive craniectomy plus best medical treatment in these patients improves outcome at 6 months compared to best medical treatment alone. METHODS: In this multicentre, randomised, open-label, assessor-blinded trial conducted in 42 stroke centres in Austria, Belgium, Finland, France, Germany, the Netherlands, Spain, Sweden, and Switzerland, adults (18-75 years) with a severe intracerebral haemorrhage involving the basal ganglia or thalamus were randomly assigned to receive either decompressive craniectomy plus best medical treatment or best medical treatment alone...
May 14, 2024: Lancet
#5
JOURNAL ARTICLE
Sahar Mihandoust, Anjali Joseph, Matthew H E M Browning, Jackie S Cha, Alec Gonzales, Jonathan Markowitz
AIM: The study aims to evaluate the impact of exposure to a highly realistic virtual facility tour prior to the on-site visit on patients and their parent/care partner's self-reported anxiety and physiological measures on the day of the procedure. BACKGROUND: Preoperative anxiety impacts pediatric surgical outcomes; therefore, it is important for healthcare providers to address and manage preoperative anxiety in pediatric patients to promote better outcomes and overall wellbeing...
May 17, 2024: Applied Ergonomics
#6
JOURNAL ARTICLE
Akash Sharma, Grace Alexander, Jian H Chu, Artemis Markopoulos, Gilgamish Maloul, Muhammad Talha Ayub, Mary J Fidler, Tochukwu M Okwuosa
BACKGROUND: Immune checkpoint inhibitors (ICIs) have uncommon associations with cardiotoxicity, yet these cardiotoxic effects are associated with high mortality. An accurate assessment of risk for cardiotoxicity is essential for clinical decision-making, but data from randomized controlled trials often differ from real-world observational studies. METHODS AND RESULTS: A systematic search of PubMed, Embase, Cochrane Library, and Scopus was performed, including phase II and III randomized controlled trials (RCTs) and observational studies (OSs) reporting myocarditis or pericardial disease, myocardial infarction, or stroke with an immunotherapy...
May 18, 2024: Journal of the American Heart Association
#7
RANDOMIZED CONTROLLED TRIAL
Fereshteh Sadeghi, Shahzad Pashaeypoor, Akbar Nikpajouh, Reza Negarandeh
BACKGROUND: Acute Coronary Syndrome is the most common heart disease and the most significant cause of death and disability-adjusted life years worldwide. Teaching a healthy eating style is one preventive measure to prevent the disease's recurrence. This study aimed to determine the effect of healthy nutrition education with the help of traffic light labels on food selection, preference, and consumption in patients with acute coronary syndrome. METHODS: This randomized, single-blinded clinical trial was conducted with 139 participants (66 in the intervention group and 73 in the control group) from January 2021 to August 2021 in Shaheed Rajaie Hospital, Tehran, Iran...
May 17, 2024: BMC Public Health
#8
JOURNAL ARTICLE
Yvonne Commodore-Mensah, Yuling Chen, Oluwabunmi Ogungbe, Xiaoyue Liu, Faith E Metlock, Kathryn A Carson, Justin B Echouffo-Tcheugui, Chidinma Ibe, Deidra Crews, Lisa A Cooper, Cheryl Dennison Himmelfarb
BACKGROUND: Hypertension and diabetes are major risk factors for cardiovascular diseases, stroke, and chronic kidney disease (CKD). Disparities in hypertension control persist among Black and Hispanic adults and persons living in poverty in the United States. The "LINKED-HEARTS Program" (a Cardiometabolic Health Program LINKED with Community Health WorkErs and Mobile HeAlth TelemonitoRing To reduce Health DisparitieS"), is a multi-level intervention that includes home blood pressure (BP) monitoring (HBPM), blood glucose telemonitoring, and team-based care...
May 15, 2024: American Heart Journal
#9
REVIEW
Abiodun Idowu, Olayinka Adebolu, Phuuwadith Wattanachayakul, Elvis Obomanu, Samir Shah, Kevin Bryan Lo, Gregg Pressman
BACKGROUND: Patients who had acute myocardial infarction are at high risk of negative cardiac outcomes and previous SGLT2i landmark trials excluded these patients. It therefore remains unclear if SGLT2i is safe and confers beneficial cardiovascular outcomes after acute myocardial infarction. METHODS: We systematically reviewed randomized controlled trials that evaluated the outcomes of adding SGLT2i to conventional post-myocardial infarction care. Random-effects model meta-analysis via RevMan 5...
May 15, 2024: Current Problems in Cardiology
#10
JOURNAL ARTICLE
Maura Kepper, Callie Walsh-Bailey, Zoe M Miller, Min Zhao, Kianna Zucker, Angeline Gacad, Cynthia Herrick, Neil H White, Ross C Brownson, Randi E Foraker
BACKGROUND: Youth overweight and obesity is a public health crisis and increases the risk of poor cardiovascular health (CVH) and chronic disease. Health care providers play a key role in weight management, yet few tools exist to support providers in delivering tailored evidence-based behavior change interventions to patients. OBJECTIVE: The goal of this pilot randomized feasibility study was to determine the feasibility of implementing the Patient-Centered Real-Time Intervention (PREVENT) tool in clinical settings, generate implementation data to inform scale-up, and gather preliminary effectiveness data...
May 17, 2024: JMIR Formative Research
#11
REVIEW
Caren M van Kammen, Seija E L Taal, Kimberley E Wever, Joey P Granger, A Titia Lely, Fieke Terstappen
BACKGROUND: The Reduced Uterine Perfusion Pressure (RUPP) model is frequently used to study preeclampsia and fetal growth restriction. An improved understanding of influential factors might improve reproducibility and reduce animal use considering the variability in RUPP phenotype. METHOD: We performed a systematic review and meta-analysis by searching Medline and Embase (until 03-28-2023) for RUPP studies in murine. Primary outcomes included: maternal blood pressure (BP) or proteinuria, fetal weight or crown-rump-length, fetal reabsorptions, or anti-angiogenic factors...
May 17, 2024: American Journal of Physiology. Heart and Circulatory Physiology
#12
JOURNAL ARTICLE
Azin Alizadehasl, Mona Malekzadeh Moghani, Hamidreza Mirzaei, Masoumeh Keshvari, Fatemeh Fadaei, Holger Cramer, Mehdi Pasalar, Ghazaleh Heydarirad
Objectives: Several studies have indicated that dietary interventions may offer protection against the development of cardiac damage in the case of anthracycline-induced cardiomyopathy (AIC). The goal of this study was to assess whether an evidence-based cardioprotective diet can be effective in preventing AIC in patients with breast cancer. Design: Randomized, open-label, controlled trial. The study period was set for 18 weeks, and the data were analyzed by generalized estimating equation modeling and one-way repeated measures analysis of variance...
May 17, 2024: J Integr Complement Med
#13
JOURNAL ARTICLE
Jiahao Song, Da Zhou, Jingrun Li, Mengqi Wang, Lina Jia, Duo Lan, Haiqing Song, Xunming Ji, Ran Meng
AIMS: The causal relationship between sarcopenia-related traits and ischemic stroke (IS) remains poorly understood. This study aimed to explore the causal impact of sarcopenia-related traits on IS and to identify key mediators of this association. METHODS: We conducted univariable, multivariable two-sample, and two-step Mendelian randomization (MR) analyses using genome-wide association study (GWAS) data. This included data for appendicular lean mass (ALM), hand grip strength (HGS), and usual walking pace (UWP) from the UK Biobank, and IS data from the MEGASTROKE consortium...
May 2024: CNS Neuroscience & Therapeutics
#14
JOURNAL ARTICLE
Styliani Partalidou, Dimitrios Patoulias, Kleopatra Deuteraiou, Paraskevi Avgerou, George Kitas, Maria Tzitiridou-Chatzopoulou, Theodoros Dimitroulas
OBJECTIVE: The aim of this study was to compare the risk of major cardiovascular events (MACE) and venous thromboembolic events (VTE) between tumour necrosis factor (TNF) and Janus kinase (JAK) inhibitors in patients with rheumatoid arthritis (RA). METHODS: We researched PubMed, Scopus, Cochrane Library, and clinicaltrials.gov until December of 2023 for randomised controlled trials (RCTs) and observational studies. The outcomes studied were MACE (stroke, heart attack, myocardial infarction, sudden cardiac death) and VTE (deep vein thrombosis, pulmonary embolism)...
March 2024: Mediterranean journal of rheumatology
#15
JOURNAL ARTICLE
Patricia V Gaya, Guilherme Wesley P Fonseca, Lucas Tsuyoshi Tanji, Tania O Abe, Maria Janieire N N Alves, Paulo Caleb Junior de Lima Santos, Fernanda M Consolim Colombo, Jaqueline R Scholz
INTRODUCTION: High blood pressure in hypertensive smokers is affected by nicotine consumption. This study aimed to evaluate the effect of smoking cessation treatments on blood pressure in hypertensive smokers. METHODS: A total of 113 hypertensive smokers on antihypertensives during smoking cessation treatment in the randomized controlled trial GENTSMOKING were considered for analysis. At Baseline (T0) and Week 12 (T12), systolic and diastolic blood pressure (SBP and DBP), and heart rate (HR) were measured using a semi-automated digital oscillometric device...
2024: Tobacco Induced Diseases
#16
JOURNAL ARTICLE
Jie Wang, Yuehui Yin, Chengzhi Lu, Zhibing Lu, Jialu Hu, Yue Wang, Junbo Ge, Hong Jiang, Chen Yao, Xiaoyan Yan, Wei Ma, Xiaoyong Qi, Yi Dang, Shaoliang Chen, Jiancheng Zhu, Dongmei Wang, Chao Ding, Weimin Wang, Jian Liu, Yanbin Wang, Hui Li, Zhenhua Pan, Kaijun Cui, Chengzong Li, Xinjian Liang, Weijie Chen, Paul A Sobotka, JingJing Zhang, Murray Esler, Ningling Sun, Minglong Chen, Yong Huo
BACKGROUND: Previous trials of renal denervation (RDN) have been designed to investigate reduction of blood pressure (BP) as the primary efficacy endpoint using non-selective RDN without intraoperatively verified RDN success. It is an unmet clinical need to map renal nerves, selectively denervate renal sympathetic nerves, provide readouts for the interventionalists and avoid futile RDN. We aimed to examine the safety and efficacy of renal nerve mapping/selective renal denervation (msRDN) in patients with uncontrolled hypertension (HTN) and determine whether antihypertensive drug burden is reduced while office systolic BP (OSBP) is controlled to target level (＜140 mmHg)...
June 2024: EClinicalMedicine
#17
COMPARATIVE STUDY
Tomislav Kopjar, Hrvoje Gasparovic, Maja Hrabak Paar, Daniel Lovric, Petra Cerina, Tomislav Tokic, Davor Milicic
BACKGROUND: The optimal antithrombotic strategy early after aortic valve replacement surgery with a biological valve remains controversial due to lack of high-quality evidence. Either oral anticoagulants or acetylsalicylic acid should be considered for the first 3 months. Hypo-attenuated leaflet thickening on cardiac computed tomography has been associated with latent bioprosthetic valve thrombosis and may be prevented with anticoagulation. We hypothesize that anticoagulation with apixaban is superior to single antiplatelet therapy with acetylsalicylic acid in reducing hypo-attenuated leaflet thickening of bioprosthetic aortic valve prostheses...
May 16, 2024: Trials
#18
RANDOMIZED CONTROLLED TRIAL
Alicia Podadera-Herreros, Antonio P Arenas-de Larriva, Francisco M Gutierrez-Mariscal, Juan F Alcala-Diaz, Ana Ojeda-Rodriguez, Fernando Rodriguez-Cantalejo, Magdalena P Cardelo, Diego Rodriguez-Cano, Jose D Torres-Peña, Raul M Luque, Jose M Ordovas, Pablo Perez-Martinez, Javier Delgado-Lista, Jose Lopez-Miranda, Elena M Yubero-Serrano
BACKGROUND: Type 2 diabetes mellitus (T2DM) is recognized an independent risk factor for chronic kidney disease (CKD). The precise contribution and differential response to treatment strategies to reduce kidney dysfunction, depending on whether obesity is present alongside T2DM or not, remain to be fully clarified. Our objective was to improve our understanding of how obesity contributes to kidney function in patients with T2DM and coronary heart disease (CHD), who are highly predisposed to CKD, to assign the most effective dietary approach to preserve kidney function...
May 16, 2024: Nutrition & Diabetes
#19
JOURNAL ARTICLE
Mattia Galli, Giovanni Occhipinti, Stefano Benenati, Renzo Laborante, Luis Ortega-Paz, Francesco Franchi, Domenico D'Amario, Roberto Nerla, Fausto Castriota, Giacomo Frati, Giuseppe Biondi-Zoccai, Sebastiano Sciarretta, Dominick J Angiolillo
BACKGROUND: Carriers of cytochrome 2C19 (CYP2C19) loss of function (LoF) alleles treated with clopidogrel have impaired drug metabolism resulting in reduced active metabolite levels, high platelet reactivity (HPR), and an increased risk of thrombotic events. Several alternative antiplatelet therapies have been proposed to overcome HPR in these patients, but their comparative effects remain poorly explored. METHODS: Randomized controlled trials (RCTs) comparing different oral antiplatelet therapies in carriers of CYP2C19 LoF alleles undergoing percutaneous coronary interventions (PCI) were included...
May 16, 2024: European Heart Journal. Cardiovascular Pharmacotherapy
#20
JOURNAL ARTICLE
Raveed Khan, Jessie Gopaulsingh, Zada Gopee, Roneice Gould, Anique Gray, Kishan Harripersad, Rachael Harripersad, Nalini Heeralal
Introduction: During the COVID-19 pandemic, Trinidad and Tobago's government implemented lockdowns and limited the availability of outpatient clinics to curb virus transmission. Subsequently, telemedicine via telephone calls was utilized to address infection control and continuity of care for chronic disease patients. Methods: An observational study was conducted at three primary care facilities in Eastern Trinidad using convenience sampling to review retrospectively telemedicine patients' medical records from October 2019 to February 2020 (before telemedicine) and from March 2020 to September 2020 (during telemedicine) for comparative analysis...
May 3, 2024: Telemedicine Journal and E-health
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