Jacob Fang, Grace Bosma, Dara Aisner, Christine McMahon, Maria Amaya, Marc Schwartz, Jeff Kaiser, Diana Abbott, Zenggang Pan, Jeffrey Schowinsky, Changlee Pang, Jonathan A Gutman, Daniel A Pollyea
Predictors for response to intensive therapy in AML have focused on baseline factors: percent leukemic blasts in marrow, cytogenetic/molecular genetic abnormalities, and presence of secondary AML. Non-baseline dynamic factors, occurring after induction but before response, may be useful for decisions related to salvage chemotherapy. We hypothesized white blood cell (WBC) count nadir after induction may be a real time indicator of treatment efficacy. We also examined whether time to stem cell transplant (SCT) or baseline molecular genetic abnormalities are associated with a low nadir...
June 2024: Leukemia & Lymphoma