Wang Manli, Qiao Hua
We aimed to investigate the effect of miR-506-3p on the proliferation and apoptosis of airway smooth muscle cells (ASMCS) in asthmatic mice by regulating the activation of TLR4/NF-κB signaling pathway through targeted regulation of C-C Motif Chemokine Ligand 2 (CCL2) expression. Twenty-four BALB/c mice of specific pathogen-free grade were selected to establish asthmatic mouse model, which were randomly divided into normal control group and asthma model group (n = 12 for each group). HE and IHC staining, bioinformatics and dual luciferase reporter assay, RT-PCR MTT, flow cytometry and Western blot were used in this research...
February 27, 2021: Molecular Biotechnology
Amaury Thiabaud, Anne Iten, Carlo Balmelli, Laurence Senn, Nicolas Troillet, Andreas Widmer, Domenica Flury, Peter W Schreiber, Miriam Vázquez, Lauro Damonti, Michael Buettcher, Danielle Vuichard-Gysin, Christoph Kuhm, Alexia Cusini, Thomas Riedel, Yvonne Nussbaumer-Ochsner, Roman Gaudenz, Ulrich Heininger, Christoph Berger, Franziska Zucol, Sara Bernhard-Stirnemann, Natascia Corti, Petra Zimmermann, Anita Uka, Anita Niederer-Loher, Céline Gardiol, Maroussia Roelens, Olivia Keiser
BACKGROUND: SARS-CoV-2/COVID-19, which emerged in China in late 2019, rapidly spread across the world with several million victims in 213 countries. Switzerland was severely hit by the virus, with 43,000 confirmed cases as of 1 September 2020. AIM: In cooperation with the Federal Office of Public Health, we set up a surveillance database in February 2020 to monitor hospitalised patients with COVID-19, in addition to their mandatory reporting system. METHODS: Patients hospitalised for more than 24 hours with a positive polymerase chain-reaction test, from 20 Swiss hospitals, are included...
February 15, 2021: Swiss Medical Weekly
Kathrin Balz, Abhinav Kaushik, Meng Chen, Franz Cemic, Vanessa Heger, Harald Renz, Kari Nadeau, Chrysanthi Skevaki
The outbreak of the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a public health emergency. Asthma does not represent a risk factor for COVID-19 in several published cohorts. We hypothesized that the SARS-CoV-2 proteome contains T cell epitopes, which are potentially cross-reactive to allergen epitopes. We aimed at identifying homologous peptide sequences by means of two distinct complementary bioinformatics approaches. Pipeline 1 included prediction of MHC Class I and Class II epitopes contained in the SARS-CoV-2 proteome and allergens along with alignment and elaborate ranking approaches...
February 26, 2021: Scientific Reports
Jonás Carmona-Pírez, Beatriz Poblador-Plou, Ignatios Ioakeim-Skoufa, Francisca González-Rubio, Luis Andrés Gimeno-Feliú, Jesús Díez-Manglano, Clara Laguna-Berna, Jose M Marin, Antonio Gimeno-Miguel, Alexandra Prados-Torres
Chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis, and obstructive sleep apnea (OSA) are amongst the most common treatable and preventable chronic conditions with high morbidity burden and mortality risk. We aimed to explore the existence of multimorbidity clusters in patients with such diseases and to estimate their prevalence and impact on mortality. We conducted an observational retrospective study in the EpiChron Cohort (Aragon, Spain), selecting all patients with a diagnosis of allergic rhinitis, asthma, COPD, and/or OSA...
February 26, 2021: Scientific Reports
Naomi A van Westen-Lagerweij, Eline Meijer, Elisabeth G Meeuwsen, Niels H Chavannes, Marc C Willemsen, Esther A Croes
No abstract text is available yet for this article.
February 26, 2021: NPJ Primary Care Respiratory Medicine
K Vishak Acharya, B Unnikrishnan, K Sindhu, S Deepthi
No abstract text is available yet for this article.
February 26, 2021: NPJ Primary Care Respiratory Medicine
Bei Wang, Lujin Wu, Jing Chen, Lingli Dong, Chen Chen, Zheng Wen, Jiong Hu, Ingrid Fleming, Dao Wen Wang
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn further metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) and cytochrome P450 (CYP) enzymes to a spectrum of bioactive mediators that includes prostanoids, leukotrienes (LTs), epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid (diHETEs), eicosatetraenoic acids (ETEs), and lipoxins (LXs)...
February 26, 2021: Signal Transduction and Targeted Therapy
Daniel F Dwyer, Jose Ordovas-Montanes, Samuel J Allon, Kathleen M Buchheit, Marko Vukovic, Tahereh Derakhshan, Chunli Feng, Juying Lai, Travis K Hughes, Sarah K Nyquist, Matthew P Giannetti, Bonnie Berger, Neil Bhattacharyya, Rachel E Roditi, Howard R Katz, Martijn C Nawijn, Marijn Berg, Maarten van den Berge, Tanya M Laidlaw, Alex K Shalek, Nora A Barrett, Joshua A Boyce
Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway, including asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP). Distinct MC subsets infiltrate the airway mucosa in T2 disease, including subepithelial MCs expressing the proteases tryptase and chymase (MCTC ) and epithelial MCs expressing tryptase without chymase (MCT ). However, mechanisms underlying MC expansion and the transcriptional programs underlying their heterogeneity are poorly understood...
February 26, 2021: Science Immunology
A Belhassen, S Toujani, A El Ouni, Z Meddeb, C Abdelkefi, T Larbi, S Hamzaoui, K Bouslama
AIM OF THE STUDY: Our study aimed to identify the characteristics of cardiac involvement in eosinophilic granulomatosis with polyangiitis (EGPA). METHODS: We conducted a retrospective analytic study including EGPA cases diagnosed between 2000 and 2019 in an internal medicine department. Diagnosis was made according to the 1990 American College of Rheumatology criteria and the 2012 Chapel Hill Concensus. RESULTS: Eleven EGPA cases were included, 64% of patients were female...
February 23, 2021: Annales de Cardiologie et D'angéiologie
Carl-Gustaf Bornehag, Elin Engdahl, Maria Unenge Hallerbäck, Sverre Wikström, Christian Lindh, Joëlle Rüegg, Eva Tanner, Chris Gennings
BACKGROUND: Experimental evidence demonstrates that exposure to bisphenol A (BPA), and the recently introduced alternatives bisphenol S (BPS) and bisphenol F (BPF) alter normal neurodevelopment. More research is needed to evaluate the associations between exposure to individual BPA alternatives and neurodevelopmental outcomes in humans. OBJECTIVE: The present study aimed at examining the individual associations between prenatal BPA, BPS and BPF exposure and cognitive outcomes in children at age 7 years...
February 19, 2021: Environment International
Tianshi David Wu, Ashraf Fawzy, Gregory L Kinney, Jessica Bon, Maniraj Neupane, Vickram Tejwani, Nadia N Hansel, Robert A Wise, Nirupama Putcha, Meredith C McCormack
BACKGROUND: Metformin is associated with improved respiratory outcomes in asthma; however, metformin in COPD and asthma-COPD overlap (ACO) remains unexplored. OBJECTIVE: To determine the association between metformin use and respiratory outcomes in COPD and ACO. STUDY DESIGN AND METHODS: Participants with COPD (FEV1/FVC < 0.70) in the Genetic Epidemiology of COPD study (COPDGene®) were categorized as ACO (n = 510), defined as concurrent physician-diagnosed asthma before age 40 years, or COPD alone (n = 3459)...
February 26, 2021: Respiratory Research
Doriane Calmes, Pascale Huynen, Virginie Paulus, Monique Henket, Françoise Guissard, Catherine Moermans, Renaud Louis, Florence Schleich
BACKGROUND: Chlamydia pneumoniae and Mycoplasma pneumoniae have been implicated in the pathogenesis of asthma and are responsible for chronic inflammation when host immune system fails to eradicate the bacteria. METHOD: We performed a prospective study on 410 patients who underwent a visit at the asthma clinic of CHU of Liege between June 2016 and June 2018 with serology testing for C. pneumoniae and M. pneumoniae. RESULTS: 65% of our asthmatic population had serum IgA and/or IgG towards C...
February 26, 2021: Respiratory Research
Muhua Huang, Ying Wei, Jingcheng Dong
Allergic asthma is a common airway inflammatory disease and mainly caused by abnormal immune responses to allergens and viruses. The precise mechanisms of airway inflammation and airway hyper-responsiveness (AHR) are still not completely understood. CD4+ helper T cells (Th cells) serve as critical regulators of allergic immunity. The imbalance between T helper 9 (Th9) cells and forkhead box protein 3 (Foxp3)+ regulatory T (Treg) cells may contribute to airway inflammation in asthma. Epimedin C, a dominant compound isolated from Herba Epimedii, has shown anti-inflammatory effects and the immunoregulatory activity, such as increase of lymphocyte proliferation...
February 23, 2021: Pulmonary Pharmacology & Therapeutics
Peter A Ricketti, Anthony J Ricketti
No abstract text is available yet for this article.
February 23, 2021: Annals of Allergy, Asthma & Immunology
Hannah Wangberg, Samantha Spierling Bagsic, John Kelso, Kathleen Luskin, Cathleen Collins
BACKGROUND: There is limited research investigating maternal dietary practices and health care provider recommendations when providing breast milk (BM) to children with IgE-mediated food allergy. OBJECTIVE: This study explored health care provider recommendations and maternal practices when providing BM to children with IgE-mediated food allergy. We also assessed for possible IgE-mediated reactions to BM while the mother consumed the food to which her child was allergic...
February 23, 2021: Annals of Allergy, Asthma & Immunology
King Pui Florence Chan, Wang-Chun Kwok, Ting-Fung Ma, Chun-Him Hui, Terence Chi-Chun Tam, Julie Kwan-Ling Wang, James Chung-Man Ho, David Chi-Leung Lam, Mary Sau-Man Ip, Pak-Leung Ho
RATIONALE: Asthma patients were advised to avoid Coronavirus disease 2019 (COVID-19) and comply to medication during COVID-19 pandemic. Respiratory tract infection is a common cause of asthma exacerbation. There has not been evidence suggesting the link between COVID-19 and asthma exacerbation, especially in places with dramatic responses in infection control with universal masking and aggressive social distancing. OBJECTIVE: To assess the number for admissions of asthma exacerbation in January to April 2020 in Hong Kong with reference to admission in past five years...
February 26, 2021: Annals of the American Thoracic Society
Patricia María O'Farrill-Romanillos, Anabel Ávila-Lara, Fabián Eduardo Álvarez-Chávez, Juan Carlos Tinajero, Ana Luisa Nayeli Torres, Edwin Daniel Maldonado-Domínguez
BACKGROUND: Asthma has a global prevalence of 18%. In work-related asthma, there is an association between asthma and the exposure to dust, vapors, or fumes only at the workplace, in patients with or without a previous asthma diagnosis; it represents approximately 5-25% of the cases of adult onset asthma. In Mexico, the information about this topic is scarce. CASE REPORT: A series of 17 patients with an asthma diagnosis and occupational exposure to dust, vapors, or fumes is reported; occupational asthma was determined by the Allergy and Clinical Immunology Service at Centro Médico Nacional Siglo XXI...
July 2020: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
María Lourdes Mendoza-Gertrudis, Alejandro Rosas-Alvarado, Aída Andrea Velasco-Medina, Héctor Alberto Cuevas-Mora, Antonio Albarrán-Godínez, Margaret Gisette Moya-Almonte, Carla Marcela Vallejos-Pereira, Guillermo Velázquez-Sámano
BACKGROUND: Allergy skin prick tests are important tools for the diagnosis of respiratory allergic diseases. Cockroach antigens have been identified as the cause of rhinitis, asthma, and other allergic diseases. OBJECTIVE: To show that the cockroach antigen participates in the cause of allergic diseases. METHODS: A retrolective and cross-sectional study was carried out, for which clinical records and history of atopy were reviewed; the results were obtained from blood biometry, nasal cytology, total IgE, and coproparasitoscopic serial tests...
July 2020: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
Sarah Raevens, Maxine Boret, Michel De Pauw, Michael B Fallon, Hans Van Vlierberghe
Pulmonary disease in liver cirrhosis and portal hypertension constitutes a challenging clinical scenario and may have important implications with regard to prognosis, liver transplantation (LT) candidacy and post-LT outcome. Pre-LT evaluation should include adequate screening for pulmonary diseases that may occur concomitantly with liver disease as well as for those that may arise as a complication of end-stage liver disease and portal hypertension, as either may jeopardize safe LT and successful outcome. It is key to discriminate those patients who would benefit from LT, especially pulmonary disorders that have been reported to resolve post-LT and are considered 'pulmonary indications' for transplant, from those who are at increased mortality risk and in whom LT is contraindicated...
February 26, 2021: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
P J Cvietusa, N M Wagner, J A Shoup, G K Goodrich, S M Shetterly, D K King, M A Raebel, C S Riggs, B Bender
BACKGROUND: Use of digital communication technology has shown potential to improve asthma adherence and outcomes. Few studies have looked at patient preference around mode of medication reminders used to improve and maintain asthma medication adherence. OBJECTIVE: To determine if, in a population already receiving automated medication reminders, offering a choice for preferred mode of reminder (text, email, phone) would improve their adherence and asthma outcomes over a 1-year period...
December 2020: Permanente Journal
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