Eric C K Lee, Brit Trogen, Kathryn Brady, Lara S Ford, Julie Wang
PURPOSE OF REVIEW: This narrative review explores food allergy prevalence and natural history stratified by life stages, especially in context of evolving knowledge over the last few decades. RECENT FINDINGS: The prevalence of food allergy remains highest in early childhood with common food triggers being cow's milk, soy, hen's egg, wheat, peanut, tree nuts, sesame, fish, and shellfish. This correlates with certain risk factors especially pertinent in the postnatal period which appear to predispose an individual to developing a food allergy...
February 28, 2024: Current Allergy and Asthma Reports
Christine T Butler, Aoife M Rodgers, Annie M Curtis, Ryan F Donnelly
Circadian rhythms influence a range of biological processes within the body, with the central clock or suprachiasmatic nucleus (SCN) in the brain synchronising peripheral clocks around the body. These clocks are regulated by external cues, the most influential being the light/dark cycle, in order to synchronise with the external day. Chrono-tailored or circadian drug delivery systems (DDS) aim to optimise drug delivery by releasing drugs at specific times of day to align with circadian rhythms within the body...
February 28, 2024: Drug Delivery and Translational Research
Nicolas Glasson, Léonard Diserens, Cyril Besson, Anton Raemy, Isabelle Rochat Guignard, Jelena Todic
Exercise-induced laryngeal obstruction (EILO) is a condition characterized by temporary narrowing or closure of the larynx during physical activity, in particular during intense physical exertion. It generally affects teenagers and young adults and is often misdiagnosed as exercise-induced asthma. Symptoms include dyspnea, wheezing and a feeling of throat tightness during exercise. The aim of this article is to review this often underrecognized condition, its diagnosis and its management.
February 28, 2024: Revue Médicale Suisse
Claudia Blouin, Catherine Lemière
PURPOSE OF THIS REVIEW: Occupational asthma (OA) is a complex condition that can be difficult to diagnose. The purpose of this review is to describe some recent findings regarding the epidemiology of OA, the occupational sensitizing agents, the prognosis of OA, and its primary prevention. RECENT FINDINGS: The risk of developing OA varies according to the geographic localization of the worker, the type of industry and the type of sensitizing agents. New findings have been reported for several known sensitizing agents, such as isocyanates, seafood & cleaning agents, and their related industries, such as hairdressing salons and schools...
February 29, 2024: Current Opinion in Pulmonary Medicine
Tahoora Abdul Nasir Surve, DhruviKumari D Sharma, Kiyan Ghani Khan, Neisha Ghanie, Riley Charanrak, Mouhammad Sharifa, Samreen Begum, Maria Jose Auz, Nozima Akbarova, Maneeth Mylavarapu
Objective To emphasize the necessity for increased research in this field, incorporating depression into the preventative, diagnostic, and therapeutic considerations for asthma. Additionally, we seek to highlight upcoming advancements that can be applied to simultaneously address these comorbidities, ultimately improving the overall well-being and quality of life for individuals coping with these conditions. Methods A rigorous search in PubMed using the MeSH terms "asthma" and "depression" was performed, and papers were screened by the authors in view of their eligibility to contribute to the study...
February 28, 2024: Journal of Asthma
Robert G Hamilton, Mark Holbreich, Charles Bronzert, Rebecca L Anderson, Nathan Schoettler, Carole Ober
Background: Screening asthma patients for atopy facilitates management. Since 2010, the core biomarker for screening asthma subjects for atopic status has been the qualitative Phadiatop. multi-aeroallergen screen. A more quantitative macroarray, the Allergy Explorer (ALEX2 ), shows promise as an alternative. Objective: The study's goal was to examine the pros and cons of the use of ALEX2 in the screening of asthma patients for atopic status. Methods: We evaluated the atopic (IgE-sensitization) status in asthmatic Amish and Hutterite farm children using the ImmunoCAP and ALEX2 assays in Phadiatop equivocal and positive subjects...
February 28, 2024: Journal of Asthma
Cristiana Indolfi, Angela Klain, Giulio Dinardo, Fabio Decimo, Maria Maddalena Marrapodi, Amelia Licari, Michele Miraglia Del Giudice
In recent years, our comprehension of the function of vitamin D has significantly evolved. The ubiquitous presence of the vitamin D receptor (Vitamin D Receptor- VDR) in the body has led to its redefinition from a steroidal hormone primarily involved in skeletal functions to a hormone with pleiotropic effects, exerting its influence on the circulatory, nervous, and immune systems. This has prompted investigations into its potential use in preventing and treating chronic metabolic disorders, cardiovascular diseases, infections, and allergic and autoimmune diseases...
February 20, 2024: Mini Reviews in Medicinal Chemistry
Ilaria Baglivo, Stefania Colantuono, Arianna Lumaca, Alfredo Papa, Antonio Gasbarrini, Cristiano Caruso
Heterogeneity characterises inflammatory diseases and different phenotypes and endotypes have been identified. Both innate and adaptive immunity contribute to the immunopathological mechanism of these diseases and barrier damage plays a prominent role triggering type 2 inflammation through the alarmins system, such as anti-Thymic Stromal Lymphopoietin (TSLP). Treatment with anti-TSLP monoclonal antibodies showed efficacy in severe asthma and clinical trials for other eosinophilic diseases are ongoing. The aim of this perspective review is to analyse current advances and future applications of TSLP inhibition to control barrier damage...
2024: Frontiers in Immunology
Henry J Kanarek, Drew Austin Saville Mutschelknaus
Hereditary angioedema (HAE) is a rare genetic disorder characterized by potentially life-threatening episodes of swelling. Most HAE cases are caused by deficient (type I) or dysfunctional (type II) C1-esterase inhibitor (C1-INH) protein. However, some patients present with a subtype of HAE that is associated with normal plasma levels of functional C1-INH protein and complement component 4 (HAE-nC1INH). Treatment of HAE-nC1INH is driven by clinical experience as robust clinical trial data to inform treatment decisions are lacking in this population...
2024: Journal of Asthma and Allergy
Camryn Daidone, Sheyenne Carper
We present a case of a three-year-old African American male, born at term, who initially presented with bronchiolitis at six months and has since experienced recurrent episodes of respiratory distress and hospitalizations. The patient also has severe eczema, developmental delays, and recurrent viral illnesses. Despite thorough evaluations from various specialists, such as pulmonology, allergy, and gastroenterology, the underlying cause remained elusive. The differential diagnosis for this case is as follows: severe persistent asthma with a possible link to genetic mutations such as CDHR3, hyper-IgE syndrome, atypical presentation of Wiskott-Aldrich syndrome, and severe gastroesophageal reflux disease (GERD) with aspiration pneumonitis...
January 2024: Curēus
Jiangyan Yong, Hongli Shu, Xiao Zhang, Kun Yang, Guining Luo, Lu Yu, Jiaqi Li, Hong Huang
Given the unique physiological and pathological characteristics of the lung, the direct, inhalable route is more conducive to pulmonary drug delivery and disease control than traditional systemic drug delivery, significantly circumventing drug loss, off-target effects, systemic and organ toxicity, etc., and is widely regarded as the preferred regimen for pulmonary drug delivery. However, very few lung diseases are currently treated with the preferred inhaled formulations, such as asthma, chronic obstructive pulmonary disease and pulmonary hypertension...
2024: International Journal of Nanomedicine
Izabela Rodzyń, Katarzyna Karpińska, Hanna Bis-Wencel, Łukasz Wlazło, Mateusz Ossowski, Katarzyna Strzelec, Sebastian Jaguszewski, Bożena Nowakowicz-Dębek
BACKGROUND: Due to the increasing prevalence of equine non-infectious respiratory disease, the air contamination in equine housing (Stables A-C) and training facilities (indoor riding arenas A - C) was investigated. The aim of the study was to monitor gaseous pollutants, bioaerosols, and dust concentrations at three different sites (stables and riding halls), where different floor materials were used in the riding halls. MATERIALS AND METHODS: Air quality was monitored in housing for horses and in riding halls in terms of dust concentration, the presence of gaseous chemical pollutants, and concentrations of biological aerosol...
February 28, 2024: BMC Veterinary Research
Florian Tagini, Onya Opota, Gilbert Greub
Chlamydia pneumoniae infection cases have usually accounted for <1.5% of community-acquired respiratory tract infections. Currently, Lausanne, Switzerland is experiencing a notable upsurge in cases, with 28 reported within a span of a few months. This upsurge in cases highlights the need for heightened awareness among clinicians.
February 27, 2024: Emerging Infectious Diseases
Alexander J K Wilkinson, Ekaterina Maslova, Christer Janson, Vasanth Radhakrishnan, Jennifer K Quint, Nigel Budgen, Trung N Tran, Yang Xu, Andrew Menzies-Gow, John P Bell
BACKGROUND: Poorly controlled asthma is associated with increased morbidity and healthcare resource utilisation (HCRU). Therefore, to quantify the environmental impact of asthma care, this retrospective, cohort, healthCARe-Based envirONmental cost of treatment (CARBON) study estimated greenhouse gas (GHG) emissions in the UK associated with the management of well-controlled versus poorly controlled asthma. METHODS: Patients with current asthma (aged ≥12 years) registered with the Clinical Practice Research Datalink (2008‒2019) were included...
February 27, 2024: Thorax
Aniek F Markus, Peter R Rijnbeek, Jan A Kors, Edward Burn, Talita Duarte-Salles, Markus Haug, Chungsoo Kim, Raivo Kolde, Youngsoo Lee, Hae-Sim Park, Rae Woong Park, Daniel Prieto-Alhambra, Carlen Reyes, Jerry A Krishnan, Guy G Brusselle, Katia Mc Verhamme
BACKGROUND: There is a lack of knowledge on how patients with asthma or chronic obstructive pulmonary disease (COPD) are globally treated in the real world, especially with regard to the initial pharmacological treatment of newly diagnosed patients and the different treatment trajectories. This knowledge is important to monitor and improve clinical practice. METHODS: This retrospective cohort study aims to characterise treatments using data from four claims (drug dispensing) and four electronic health record (EHR; drug prescriptions) databases across six countries and three continents, encompassing 1...
February 27, 2024: BMJ Open Respiratory Research
Gábor Tomisa, Balázs Sánta, Alpár Horváth, László Németh, Balázs Tamás, Gabriella Gálffy, Lilla Tamási, Noémi Eszes
INTRODUCTION: Asthma is the most prevalent obstructive pulmonary disease, with drastically improved treatment options over the past decades. However, there is still a proportion of patients with suboptimal level of asthma control, leading to multiple hospitalisation due to severe acute exacerbation (SAE) and earlier death. In our study, we aimed to assess the risk of SAEs and mortality in patients who suffered an SAE. METHODS: The database of the National Health Insurance Fund was used to retrospectively analyse the data of all asthmatic patients who had been hospitalised for an SAE between 2009 and 2019...
February 27, 2024: BMJ Open Respiratory Research
Alon Y Hershko, Francesca Levi-Schaffer
No abstract text is available yet for this article.
February 25, 2024: Annals of Allergy, Asthma & Immunology
Timothy Craig, Kristina Richwine, Faoud T Ishmael
BACKGROUND: Hereditary angioedema (HAE) is an autosomal dominant disease with variable expression. In some families with identical genetic abnormality, the expression can range from several attacks per month to no attacks at all. It is hypothesized that post-transcriptional gene regulation account for the variable expression of the disease. OBJECTIVE: We sought to identify candidate micro-ribonucleic acids (miRNAs) that could play a role in HAE by determining whether miRNAs differentially expressed in HAE vs...
February 25, 2024: Annals of Allergy, Asthma & Immunology
Syeda Fabeha Husain, Andrea Cremaschi, Noor Hidayatul Aini Suaini, Maria De Iorio, Evelyn X L Loo, Lynette P Shek, Anne E N Goh, Michael J Meaney, Elizabeth H Tham, Evelyn C Law
OBJECTIVE: Maternal history of inflammatory conditions has been linked to offspring developmental and behavioural outcomes. This phenomenon may be explained by the maternal immune activation (MIA) hypothesis, which posits that dysregulation of the gestational immune environment affects foetal neurodevelopment. The timing of inflammation is critical. We aimed to understand maternal asthma symptoms during pregnancy, in contrast with paternal asthma symptoms during the same period, on child behaviour problems and executive function in a population-based cohort...
February 25, 2024: Brain, Behavior, and Immunity
Tong Gong, Bronwyn K Brew, Cecilia Lundholm, Awad I Smew, Arvid Harder, Ralf Kuja-Halkola, Jonas F Ludvigsson, Yi Lu, Catarina Almqvist
BACKGROUND: Little is known about shared origins between inflammatory bowel disease (IBD) and allergic diseases (asthma, allergic rhinitis, and eczema). We aimed to expand current knowledge on the etiological sources of comorbidities between these disorders using a range of genetically informed methods. METHODS: Within-individual and familial co-aggregation analysis was applied to 2 873 445 individuals born in Sweden from 1987 to 2014 and their first- and second-degree relatives...
February 27, 2024: Inflammatory Bowel Diseases
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