Jean-Luc Jougleux, Jacob L Léger, Marie-Ange Djeungoue-Petga, Patrick Roy, Marie-France N Soucy, Vanessa Veilleux, Mathieu P A Hébert, Etienne Hebert-Chatelain, Luc H Boudreau
Neutrophils play a key role in the innate immunity with their ability to generate and release inflammatory mediators that promote the inflammatory response and consequently restore the hemostasis. As active participants in several steps of the normal inflammatory response, neutrophils are also involved in chronic inflammatory diseases such as asthma, atherosclerosis, and arthritis. Given their dual role in the modulation of inflammation, regulating the inflammatory response of neutrophils has been suggested as an important therapeutic approach by numerous researchers...
April 7, 2021: Molecular Immunology
Weily Soong, Bongin Yoo, Hooman Pazwash, Cecile T J Holweg, Thomas B Casale
BACKGROUND: The anti-IgE therapy omalizumab improves asthma control and reduces exacerbations in patients with moderate-to-severe allergic asthma. However, it has been suggested that omalizumab should be reserved for highly allergic patients with multiple allergen sensitivities or perennial-only sensitivities. OBJECTIVE: To examine impact of allergy burden, including number and type of allergen sensitivities, on omalizumab response in a real-world setting. METHODS: The present post hoc analysis examined a subset of omalizumab-treated patients from PROSPERO (NCT01922037) who had complete 13-allergen assessments (N=478)...
April 7, 2021: Annals of Allergy, Asthma & Immunology
Guillermo Rodriguez-Nava, Goar Egoryan, Daniela Patricia Trelles-Garcia, Maria Adriana Yanez-Bello, Ricardo Murguia-Fuentes
No abstract text is available yet for this article.
April 7, 2021: Annals of Allergy, Asthma & Immunology
Hailey A Benesch, Vidya L Atluri, Bailey Coerver, Lahari Rampur
No abstract text is available yet for this article.
April 7, 2021: Annals of Allergy, Asthma & Immunology
Sabrina Bianca Bennstein, Markus Uhrberg
In the last decade, innate lymphoid cells (ILCs) have become established as important players in different areas such as tissue homeostasis, integrity of mucosal barriers, and regulation of inflammation. While most of the early work on ILCs was based on murine studies, our knowledge on human ILCs is rapidly accumulating, opening novel perspectives towards the translation of ILC biology into the clinic. In this State-of-the-Art Review, we focus on the current knowledge of these most recently discovered members of the lymphocyte family and highlight their role in three major burdens of humanity: infectious diseases, cancer, and allergy and/or autoimmunity...
April 9, 2021: FEBS Journal
Michal A Stanczak, David E Sanin, Petya Apostolova, Gabriele Nerz, Dimitrios Lampaki, Maike Hofmann, Daniel Steinmann, Marvin Krohn-Grimberghe, Robert Thimme, Gerhard Mittler, Cornelius F Waller, Edward J Pearce, Erika L Pearce
Our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still developing. We perform an observational study to investigate seroprevalence and immune responses in subjects professionally exposed to SARS-CoV-2 and their family members (155 individuals; ages 5-79 years). Seropositivity for SARS-CoV-2 Spike glycoprotein aligns with PCR results that confirm the previous infection. Anti-Spike IgG/IgM titers remain high 60 days post-infection and do not strongly associate with symptoms, except for fever...
April 9, 2021: Nature Communications
Imogen P Skene, Paul E Pfeffer
No abstract text is available yet for this article.
April 9, 2021: Thorax
Bing Liu, Junxia Wang, Zhijuan Ren
Asthma is a respiratory disease with a dramatically increasing incidence globally. The present study explored the roles of S-phase kinase-associated protein 2 (SKP2) and forkhead box O3 (FOXO3) in asthma and their involvement in the Krüppel-like factor 15-lipoprotein receptor-related protein 5 (KLF15-LRP5) axis. SKP2 expression in patients with asthma and OVA-induced asthmatic Sprague Dawley rats was detected by reverse transcription quantitative PCR and Western blot assays. Alterations in SKP2 and LRP5 expression were evaluated in OVA-induced asthmatic rats, followed by measurement of inflammatory cytokines using ELISA and airway resistance using a methacholine challenge test...
April 9, 2021: Journal of Immunology
Sara Vázquez-Mera, José G Pichel, Francisco Javier Salgado
No abstract text is available yet for this article.
March 11, 2021: Archivos de Bronconeumología
Wan-Ru Wang, Nai-Tzu Chen, Nai-Yun Hsu, I-Ying Kuo, Hsin-Wen Chang, Jiu-Yao Wang, Huey-Jen Su
BACKGROUND: Dysregulation of thymic stromal lymphopoietin (TSLP) expressions is linked to asthma and allergic disease. Exposure to phthalate esters, a widely used plasticizer, is associated with respiratory and allergic morbidity. Dibutyl phthalate (DBP) causes TSLP upregulation in the skin. In addition, phthalate exposure is associated with changes in environmentally induced DNA methylation, which might cause phenotypic heterogeneity. This study examined the DNA methylation of the TSLP gene to determine the potential mechanism between phthalate exposure and allergic diseases...
April 9, 2021: Clinical Epigenetics
Mohsen Sadatsafavi, Amir Khakban, Hamid Tavakoli, Solmaz Ehteshami-Afshar, Larry D Lynd, J Mark FitzGerald
BACKGROUND: Oral corticosteroids are important components of pharmacotherapy in severe asthma. Our objective was to describe the extent, trends, and factors associated with exposure to oral corticosteroids (OCS) in a severe asthma cohort. METHODS: We used administrative health databases of British Columbia, Canada (2000-2014) and validated algorithms to retrospectively create a cohort of severe asthma patients. Exposure to OCS within each year of follow-up was measured in two ways: maintenance use as receiving on average ≥ 2...
April 9, 2021: Respiratory Research
Hyunok Choi, Miroslav Dostal, Anna Pastorkova, Pavel Rossner, Radim J Sram
BACKGROUND: Asthma represents a syndrome for which our understanding of the molecular processes underlying discrete sub-diseases (i.e., endotypes), beyond atopic asthma, is limited. The public health needs to characterize etiology-associated endotype risks is becoming urgent. In particular, the roles of polyaromatic hydrocarbon (PAH), globally distributed combustion by-products, toward the two known endotypes - T helper 2 cell high (Th2) or T helper 2 cell low (non-Th2) - warrants clarification...
April 9, 2021: Environmental Health
Shabarinath Nambiar, Britt Clynick, Bong S How, Adam King, E Haydn Walters, Nicole S Goh, Tamera J Corte, Robert Trengove, Dino Tan, Yuben Moodley
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by fibrosis and progressive loss of lung function. The pathophysiological pathways involved in IPF are not well understood. Abnormal lipid metabolism has been described in various other chronic lung diseases including asthma and chronic obstructive pulmonary disease (COPD). However, its potential role in IPF pathogenesis remains unclear. METHODS: In this study, we used ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) to characterize lipid changes in plasma derived from IPF patients with stable and progressive disease...
April 9, 2021: Respiratory Research
Edward C Kuan, William P Kennedy, Neil N Patel, Khodayar Goshtasbi, Michael A Kohanski, Charles C L Tong, Peter Papagiannopoulos, David W Kennedy, James N Palmer, Nithin D Adappa, John V Bosso
PURPOSE: This study evaluated whether stratified preoperative, pre- aspirin desensitization (AD) sinonasal symptom scores predict postoperative, post-AD outcomes in Aspirin exacerbated respiratory disease (AERD). MATERIALS AND METHODS: Retrospective chart review of patients with aspirin challenge-proven AERD who underwent endoscopic sinus surgery followed by AD was performed. Preoperative, postoperative/pre-AD, and postoperative/post-AD sinonasal symptom scores were collected (22-item Sino-Nasal Outcomes Test, SNOT-22)...
March 31, 2021: American Journal of Otolaryngology
María Dolores Ibáñez-Sandín, Carmelo Escudero, Rocío Candón Morillo, Eva M Lasa, Eva Marchán-Martín, Silvia Sánchez-García, Soledad Terrados, Carlos González Díaz, Sonsoles Juste, Antonio Martorell, Vanessa Gázquez García, Antonio Ramírez Jiménez, Ángel Abellán, María D Martos Calahorro, Ana I Tabar, Joan Bartra, Rosa García Rodríguez, Catalina Gómez Galán, María Flora Martín-Muñoz, José Meseguer Arce, Juan C Miralles, Ana M Montoro de Francisco, Paloma Poza Guedes, Pablo Rodríguez Del Río
BACKGROUND: Oral immunotherapy is a frequent treatment for the management of food allergies, but adverse events (AE) are common. This study assessed the outcome of cow's milk oral immunotherapy (MOIT) in severe cow`s milk allergic patients treated with omalizumab in a real-life setting. METHODS: OmaBASE was a national, multicenter, open and observational registry that collected clinical, immunological and treatment data from patients with food allergy receiving omalizumab...
April 9, 2021: Pediatric Allergy and Immunology
Hans Jacob L Koefoed, Annelies M Zwitserloot, Judith M Vonk, Gerard H Koppelman
BACKGROUND: It is unclear in which periods of life lung function deficits develop, and if these are affected by risk factors such as asthma, bronchial hyperresponsiveness (BHR) and allergic comorbidity. The goal of this systematic review is to identify temporal associations of asthma, BHR and allergic comorbidity with large and small lung function development from birth until peak function in early adulthood. METHODS: We searched Medline, EMBASE, Web of Science and CINHAHL for papers published before 01...
April 9, 2021: Pediatric Allergy and Immunology
Martin Kaul, Peter End, Maciej Cabanski, Carole Schuhler, Annamaria Jakab, Magdalena Kistowska, Arvind Kinhikar, Alessio Maiolica, Angela Sinn, Rainard Fuhr, Bruno Cenni
Safe and effective new oral therapies for autoimmune, allergic, and inflammatory conditions remain a significant therapeutic need. Here, we investigate the human pharmacokinetics, pharmacodynamics (PDs), and safety of the selective, covalent Bruton's tyrosine kinase (BTK) inhibitor, remibrutinib. Study objectives were explored in randomized single and multiple ascending dose (SAD and MAD, respectively) cohorts with daily doses up to 600 mg, and a crossover food effect (FE) cohort, in adult healthy subjects without (SAD [n =80]/FE [n =12]) or with asymptomatic atopic diathesis (MAD [n =64])...
April 9, 2021: Clinical and Translational Science
Cynthia B Baard, Zoe Franckling-Smith, Jacinta Munro, Lesley Workman, Heather J Zar
Background: South Africa has undergone major economic and health system changes, impacting the epidemiology of childhood asthma. This study aimed to investigate prevalence time trends of asthma in South African adolescents over two decades and to identify associated risk factors. Methods: A cross-sectional survey was conducted in 2017, in a randomised sample of 13-14-year-old Cape Town adolescents, using the standardised Global Asthma Network written, video and environmental questionnaires...
April 2021: ERJ Open Research
Woo-Jung Song, Ha-Kyeong Won, Suh Young Lee, Han-Ki Park, You Sook Cho, Kian Fan Chung, Liam G Heaney, Woo Joung Joung
Exacerbation is a defining feature of severe asthma, and oral corticosteroids (OCSs) are frequently prescribed to manage exacerbations. This qualitative study was conducted to examine the experience of patients with severe asthma, with a focus on asthma exacerbation and OCS treatment. Adults with severe asthma were recruited from three tertiary hospitals in South Korea. Data were collected through in-depth qualitative interviews. Verbatim transcripts were analysed using Colaizzi's phenomenological method to uncover the meaning of the participants' experience...
April 2021: ERJ Open Research
Jeremy A Scott, Harm Maarsingh, Fernando Holguin, Hartmut Grasemann
Nitric oxide (NO) is produced by a family of isoenzymes, nitric oxide synthases (NOSs), which all utilize L-arginine as substrate. The production of NO in the lung and airways can play a number of roles during lung development, regulates airway and vascular smooth muscle tone, and is involved in inflammatory processes and host defense. Altered L-arginine/NO homeostasis, due to the accumulation of endogenous NOS inhibitors and competition for substrate with the arginase enzymes, has been found to play a role in various conditions affecting the lung and in pulmonary diseases, such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), pulmonary hypertension, and bronchopulmonary dysplasia...
2021: Frontiers in Pharmacology
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