Carla Rognoni, Carlo Milano, Enrico Heffler, Matteo Bonini, Luisa Brussino, Giovanna Elisiana Carpagnano, Fabio Luigi Massimo Ricciardolo, Francesco Costa, Patrizio Armeni
BACKGROUND: Asthma is a common chronic inflammatory airway affecting over 260 million people worldwide, and characterized, in the large majority of cases, by the so-called "type 2 inflammation". Fractional exhaled nitric oxide (FENO ) testing is noninvasive point-of-care tool to assess type 2 inflammation and therefore improve asthma management. It has been suggested to determine eligibility for a specific biologic therapy and predict likelihood to respond. The aim of this study was to estimate the overall economic impact of an extensive use of FENO testing on the Italian population with asthma, including extra costs of testing and savings generated by more appropriate prescriptions, increased adherence and lower frequency of exacerbations...
June 2, 2023: Respiratory Research
Hangyu Xie, Zhen Zhao, Wenjie Zhang, Lin Li
OBJECTIVE: To investigate the role of V/P SPECT/CT and HRCT quantitative parameters in evaluating COPD and asthma disease severity, airway obstructivity-grade, ventilation and perfusion distribution patterns, airway remodeling, and lung parenchymal changes. METHOD: Fifty-three subjects who underwent V/P SPECT/CT, HRCT, and pulmonary function tests (PFTs) were included. Preserved lung ventilation (PLVF), perfusion function (PLPF), airway obstructivity-grade (OG), proportion of anatomical volume, ventilation and perfusion contribution of each lobe, and V/P distribution patterns were evaluated using V/P SPECT/CT...
June 3, 2023: Annals of Nuclear Medicine
Julien Heitmann, Alban Glangetas, Jonathan Doenz, Juliane Dervaux, Deeksha M Shama, Daniel Hinjos Garcia, Mohamed Rida Benissa, Aymeric Cantais, Alexandre Perez, Daniel Müller, Tatjana Chavdarova, Isabelle Ruchonnet-Metrailler, Johan N Siebert, Laurence Lacroix, Martin Jaggi, Alain Gervaix, Mary-Anne Hartley
The interpretation of lung auscultation is highly subjective and relies on non-specific nomenclature. Computer-aided analysis has the potential to better standardize and automate evaluation. We used 35.9 hours of auscultation audio from 572 pediatric outpatients to develop DeepBreath : a deep learning model identifying the audible signatures of acute respiratory illness in children. It comprises a convolutional neural network followed by a logistic regression classifier, aggregating estimates on recordings from eight thoracic sites into a single prediction at the patient-level...
June 2, 2023: NPJ Digital Medicine
Mónica Climente-Martí, Manuela Alvarado-Arenas, Pilar Ausín-Herrero, Cristina Benito-Bernáldez, Nuria Carballo-Martínez, Julio Delgado-Romero
Asthma is a chronic respiratory disease with a high health, social and economic impact, particularly in the case of Severe Uncontrolled Asthma (SUA). For this reason, new strategies are especially necessary to improve its approach, with a personalized approach to each patient and from a multidisciplinary perspective, in addition to integrating the new telemedicine and telepharmacy practices promoted as a result of the COVID-19 pandemic. In this context, the TEAM 2.0 project ("Work in Multidisciplinary Asthma Teams") has been developed, following the TEAM project carried out in 2019, with the aim of updating and prioritizing good multidisciplinary work practices in SUA in a post pandemic context and analyze the progress made...
May 31, 2023: Farmacia Hospitalaria
Pinja Ilmarinen, Anna Julkunen-Iivari, Marie Lundberg, Annika Luukkainen, Mikko Nuutinen, Jussi Karjalainen, Heini Huhtala, Juha Pekkanen, Hannu Kankaanranta, Sanna Toppila-Salmi
BACKGROUND: Phenotypes of adult asthma have been identified in previous studies but rarely in population-based settings. OBJECTIVE: To identify clusters of adult-onset asthma, in a Finnish population-based study on subjects born before 1967. METHODS: We used population-based data from 1350 asthmatics with adult-onset asthma (Adult Asthma in Finland) from Finnish national registers. Twenty-eight covariates were selected based on literature...
May 31, 2023: Journal of Allergy and Clinical Immunology in Practice
Xiao-Lu Jie, Zi-Rui Luo, Jin Yu, Zhe-Ren Tong, Qiao-Qiao Li, Jia-Hui Wu, Yi Tao, Pei-Shi Feng, Ji-Ping Lan, Ping Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Pi-Pa-Run-Fei-Tang (PPRFT) is an empirical TCM prescription for treating asthma. However, the underlying mechanisms of PPRFT in asthma treatment have yet to be elucidated. Recent advances have revealed that some natural components could ameliorate asthma injury by affecting host metabolism. Untargeted metabolomics can be used to better understand the biological mechanisms underlying asthma development and identify early biomarkers that can help advance treatment...
May 31, 2023: Journal of Ethnopharmacology
Xingbao Tao, Juan Li, Jun He, Yunbin Jiang, Chunshan Liu, Weiguo Cao, Hao Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Pinellia ternata (Thunb.) Breit. (PT) has been demonstrated to be effective against the allergic airway inflammation (AAI) in clinical practices, especially in cold asthma (CA). Until now, the active ingredients, protective effect, and possible mechanism of PT against CA remain unknown. AIM OF THE STUDY: The aim of this investigation was to examine the therapeutic impact and elucidate the underlying mechanism of PT on the AAI of CA...
May 31, 2023: Journal of Ethnopharmacology
Duong Duc Pham, Ji-Hyang Lee, Hyouk-Soo Kwon, Woo-Jung Song, You Sook Cho, Hyunkyoung Kim, Jae-Woo Kwon, So-Young Park, Sujeong Kim, Gyu Young Hur, Byung Keun Kim, Young-Hee Nam, Min-Suk Yang, Mi-Yeong Kim, Sae-Hoon Kim, Byung-Jae Lee, Taehoon Lee, So Young Park, Min-Hye Kim, Young-Joo Cho, ChanSun Park, Jae-Woo Jung, Han Ki Park, Joo-Hee Kim, Ji-Yong Moon, Ian Adcock, Kian Fan Chung, Tae-Bum Kim
BACKGROUND: Although various monoclonal antibodies have been used as add-on therapy for eosinophilic severe asthma (ESA), no direct head-to-head comparative study has evaluated their efficacy. OBJECTIVE: To compare the efficacy of reslizumab, mepolizumab, and dupilumab in patients with ESA through a multicenter prospective observational study. METHODS: Ninety-six ESA patients who had received one of these biological agents for at least six months were included in the study...
May 31, 2023: Annals of Allergy, Asthma & Immunology
Gail Tan, Matthew Viveiros, Monica T Kraft
No abstract text is available yet for this article.
May 31, 2023: Annals of Allergy, Asthma & Immunology
Sandra Ekstedt, Vilma Lagebro, Susanna Kumlien Georén, Lars Olaf Cardell
BACKGROUND: Allergic asthma is a heterogeneous disorder involving chronic airway inflammation, reversible airflow limitation and tissue remodeling, causing chronic airflow limitation. Most of the asthma research has been focused on elucidating the pro-inflammatory pathways underlying disease pathogenesis. Paradoxically, the necessity of appropriate termination and resolution of inflammation has not been recognized until recently. The latter has led to the concept of chronic inflammation developing as a result of lack of specific 'stop' signals for the inflammatory process...
May 31, 2023: Annals of Allergy, Asthma & Immunology
Ting Lei, Mingqing Li, Zewu Zhu, Junxiao Yang, Yihe Hu, Long Hua
BACKGROUND: Accumulating epidemiological studies have demonstrated that smoking caused damage to human health. However, these studies almost focused on the individual smoking pattern rather than the toxic ingredients of tobacco smoke. Despite the exact accuracy of cotinine as a smoking exposure biomarker, there were few studies investigating the association between serum cotinine and human health. This study aimed to provide novel evidence about the harmful effect of smoking on systemic health from the perspective of serum cotinine...
May 31, 2023: Science of the Total Environment
Yuna Jiang, Thi Van Nguyen, Juan Jin, Zhen Nan Yu, Chang Ho Song, Ok Hee Chai
Combined allergic rhinitis and asthma syndrome (CARAS) causes chronic respiratory inflammation in allergic individuals. Long-term exposure to particulate matter 2.5 (PM2.5; particles 2.5 µm or less in diameter) can aggravate respiratory damage. Bergapten (5-methoxysporalen) is a furocoumarin mostly found in bergamot essential oil and has significant antioxidant, anticancer, and anti-inflammatory activity. This study created a model in which CARAS was exacerbated by PM2.5 exposure, in BALB/c mice and explored the potential of bergapten as a therapeutic agent...
May 31, 2023: Biomedicine & Pharmacotherapy
Haiyan Wang, Rongqiong Ou, Bihong Zhang, Sha Li, Yong Liu, Weiping Tan
Objective: The present study was aimed to investigate the efficacy of leflunomide in idiopathic pulmonary hemosiderosis (IPH) disease control and glucocorticoid attenuation. Methods: The efficacy of leflunomide was determined based on disease control, safety, and glucocorticoid attenuation. Result: A total of 46 children with IPH were included in the present study. Of these 31 patients had been unsuccessfully treated with glucocorticoids before admission at our hospital and did not achieve complete remission; the other 15 patients had not previously received steroids...
June 2, 2023: Pediatric Allergy, Immunology, and Pulmonology
Rui Zhu, Xiaoning Wang, Eric Anderson, Michelle Deng, Scott Pivirotto, Jin Jin, Nastya Kassir, Ryan Owen
Omalizumab is the first approved anti-immunoglobulin E (IgE) agent for the treatment of moderate to severe persistent inadequately controlled allergic asthma in adults and adolescents (≥ 12 years old). In 2016, it was approved in pediatric patients (6-11 years old). The objective of this study was to quantitatively characterize the relationship between serum free IgE and pulmonary function (as measured by forced expiratory volume in 1 s [FEV1]) in pediatrics using a population-based pharmacodynamic model...
June 2, 2023: AAPS Journal
Yu-Chien Chang, Hsin-Yi Huang, Tsung-Hua Shen, Chung-Hsuen Wu
Polypharmacy has become a major health issue for pregnant woman due to the increased trend of medication use during pregnancy. However, data on medication use in pregnancy are limited since pregnant women are rarely included in clinical trials. Our study aimed to investigate the trends of and characteristics associated with polypharmacy among pregnant women in the US. This study was conducted using data from The National Health and Nutrition Examination Survey in the US. Nine The National Health and Nutrition Examination Survey cycles between 1999 and 2016 were used to identify pregnant women aged 15 to 44 years...
June 2, 2023: Medicine (Baltimore)
Journal Of Healthcare Engineering
[This retracts the article DOI: 10.1155/2022/2005196.].
2023: Journal of Healthcare Engineering
Chalerm Liwsrisakun, Warawut Chaiwong, Chaicharn Pothirat
BACKGROUND: Small airways play a major role in the pathogenesis and prognosis of chronic obstructive pulmonary disease (COPD) and asthma. More data on small airway dysfunction (SAD) using spirometry and impulse oscillometry (IOS) in these populations are required. The objective of this study was to compare the two methods, spirometry and IOS, for SAD detection and its prevalence defined by spirometry and IOS in subjects with COPD and asthma with and without fixed airflow obstruction (FAO)...
2023: Frontiers in Medicine
Imran Howell, Aleksandra Howell, Ian D Pavord
The field of asthma has undergone a dramatic change in recent years. Advances in our understanding of type 2 airway inflammation have driven the discovery of monoclonal antibodies targeting specific aspects of the immune pathway. In landmark trials, these drugs have shown efficacy in reducing asthma attacks and exposure to oral corticosteroids, important causes of morbidity in people with asthma. Our review explores the key features of type 2 inflammation in asthma and summarizes the clinical trial evidence of the novel monoclonal antibody treatments and future avenues for treatment...
July 3, 2023: Journal of Experimental Medicine
Sara Alves, João Cavaleiro Rufo, José Crispim
BACKGROUND: Asthma is a highly prevalent disease, one of the chronic diseases with the highest economic costs; thus, it imposes a high economic burden on society, the healthcare system, patients, and third-party payers. Contrary to this study, until now, systematic reviews of economic evaluations (EEs) of treatments for severe asthma have not been exclusively focused on biological treatments, and have included a small number of studies and only model-based EEs. METHODS: This study systematically reviews EEs of biological therapies for severe asthma published until December 2022 using PRISMA guidelines...
June 2, 2023: Expert Review of Pharmacoeconomics & Outcomes Research
Zahra Salehi, Bibi Fatemeh Nobakht Motlagh Ghoochani, Yazdan Hasani Nourian, Sadegh Azimzadeh Jamalkandi, Mostafa Ghanei
The effects of nicotine and cigarette smoke in many diseases, notably COVID-19 infection, are being debated more frequently. The current basic data for COVID-19 is increasing and indicating the higher risk of COVID-19 infections in smokers due to the overexpression of corresponding host receptors to viral entry. However, current multi-national epidemiological reports indicate a lower incidence of COVID-19 disease in smokers. Current data indicates that smokers are more susceptible to some diseases and more protective of some other...
June 1, 2023: Allergy, Asthma, and Clinical Immunology
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