Ke Deng, Xin Zhang, Ying Liu, Li Zhang, Gang Wang, Min Feng, Brian G Oliver, Lei Wang, Philip M Hansbro, Lin Qin, Min Xie, Zhi Hong Chen, Jodie Simpson, Jie Zhang, Wei Min Li, Gang Wang, Peter Gerard Gibson
BACKGROUND: Asthma, a heterogeneous disease, can be divided into four inflammatory phenotypes using induced sputum cell counts -eosinophilic asthma (EA), neutrophilic asthma (NA), mixed granulocytic asthma (MGA), and paucigranulocytic asthma (PGA). While research has focused on EA and NA, there is little known on PGA. OBJECTIVE: To study the heterogeneity of PGA, and identify possible PGA clusters to guide clinical treatment. METHODS: Patients with PGA were grouped by hierarchical cluster analysis, and enrolled into a prospective cohort study to validate the clusters, relative to future risk of asthma exacerbations in a real-world setting...
January 19, 2021: Journal of Allergy and Clinical Immunology in Practice