Yang Yao, Mengning Zheng, Niyati A Borkar, Michael A Thompson, Emily Y Zhang, Maunick Lefin Koloko Ngassie, Shengyu Wang, Christina M Pabelick, Elizabeth R Vogel, Y S Prakash
Alteration in the normal mechanical forces of breathing can contribute to changes in contractility and remodeling characteristic of airway diseases, but the mechanisms that mediate these effects in airway cells are still under investigation. Airway smooth muscle (ASM) cells contribute to both contractility and extracellular matrix (ECM) remodeling. In this study, we explored ASM mechanisms activated by mechanical stretch, focusing on mechanosensitive piezo channels and the key Ca2+ regulatory protein stromal interaction molecule 1 (STIM1)...
May 21, 2024: American Journal of Physiology. Lung Cellular and Molecular Physiology
Meiping Chen, Yijun Ge, Wen Zhang, Ping Wu, Chao Cao
PURPOSE: Little research has explored the proteomic characteristics of nasal lavage fluid from asthmatic patients. This study aims to investigate whether differentially expressed proteins (DEPs) in nasal lavage fluid can serve as a biomarker to differentiate asthma patients from healthy controls (HCs) and to discern between individuals with well controlled and poorly controlled asthma. PATIENTS AND METHODS: We enrolled patients with allergic rhinitis (AR), asthma, or both conditions, and HCs in this study...
2024: Journal of Asthma and Allergy
Ruchong Chen, Liping Wei, Yuanrong Dai, Zaiyi Wang, Danrong Yang, Meiling Jin, Cui Xiong, Ting Li, Shuling Hu, Jie Song, Robert Chan, Subramanya Kumar, Azza Abdelkarim, Nanshan Zhong
BACKGROUND: In China, the prevalence of severe asthma with eosinophilic phenotype is rising, yet treatment options are limited. Mepolizumab is the first targeted biologic therapy for eosinophilic-driven disease in China. This study ( identifier NCT03562195) evaluated efficacy and safety of mepolizumab in Chinese patients with severe asthma. METHODS: The phase III, multicentre, randomised, placebo-controlled, double-blind, parallel-group study enrolled patients aged ≥12 years with severe asthma, with two or more exacerbations in the previous year, and on inhaled corticosteroids plus at least one controller medication...
May 2024: ERJ Open Research
Wenjuan Zhan, Huifang Zhang, Yufei Su, Li Yin
Asthma is an inflammatory disease. Airway epithelial cell pyroptosis and cytokine secretion promote asthma progression. Tripartite motif 47 (TRIM47) belongs to the E3 ubiquitin ligase family and is associated with apoptosis and inflammation in a range of diseases. However, the role of TRIM47 in asthma has not been explored. In this study, the human bronchial epithelial cell line BEAS-2B was treated with house dust mite (HDM) and TRIM47 expression was detected by RT-qPCR and Western blot. After transfection with TRIM47 interfering and overexpressing plasmids, the synthesis and secretion of cytokines, as well as pyroptosis-related indicators, were examined...
May 20, 2024: Cell Biology International
Amy Lee Hall, Pranati Movva, Rhonda Dailey, Wanda Gibson-Scipio, Alan P Baptist, Karen Kolmodin MacDonell
BACKGROUND: Emerging adults (aged 18-29) are less likely to receive the COVID-19 vaccine than any other adult age group. Black Americans are less likely than non-Hispanic white Americans to be fully vaccinated against COVID-19. This study explored factors which affect vaccine intention and attitudes in Black American emerging adults with asthma. METHODS: Participants were recruited from an NHLBI-funded clinical trial to improve asthma control. Fifty-nine Black American emerging adults completed a Qualtrics survey that assessed asthma control, intention to vaccinate, and factors which may affect the decision to vaccinate...
May 20, 2024: BMC Public Health
Virginie Doyen, Nicolas Migueres, Alexandra Frère, Jolanta Walusiak-Skorupa, Marta Wiszniewska, Hille Suojalehto, Xavier Munoz, Christian Romero-Mesones, Vera van Kampen, Joaquin Sastre, Santiago Quirce, Pilar Barranco, Catherine Rifflart, Frédéric de Blay, Olivier Vandenplas
BACKGROUND: Assessment of IgE-mediated sensitization to flour allergens is widely used to investigate flour-induced occupational asthma. The diagnostic efficiency of detecting specific IgE antibodies (sIgE) against wheat and rye flour, however, has not been thoroughly compared to other diagnostic procedures. OBJECTIVE: We sought to evaluate the diagnostic accuracy of sIgE against wheat and rye compared to specific inhalation challenge (SIC) with flour as the reference standard...
May 18, 2024: Journal of Allergy and Clinical Immunology in Practice
Ghislaine Scelo, Trung N Tran, Tham T Le, Malin Faregås, Delbert Dorscheid, John Busby, Mona Al-Ahmad, Riyad Al-Lehebi, Alan Altraja, Aaron Beastall, Celine Bergeron, Leif Bjermer, Anne S Bjerrum, Diana Jimena Cano-Rosales, Giorgio Walter Canonica, Victoria Carter, Jeremy Charriot, George C Christoff, Borja G Cosio, Eve Denton, Maria Jose Fernandez-Sanchez, João A Fonseca, Peter G Gibson, Celine Goh, Liam G Heaney, Enrico Heffler, Mark Hew, Takashi Iwanaga, Rohit Katial, Mariko S Koh, Piotr Kuna, Désirée Larenas-Linnemann, Lauri Lehtimäki, Bassam Mahboub, Neil Martin, Hisako Matsumoto, Andrew N Menzies-Gow, Nikolaos G Papadopoulos, Pujan Patel, Luis Perez-De-Llano, Matthew Peters, Paul E Pfeffer, Todor A Popov, Celeste M Porsbjerg, Chin K Rhee, Mohsen Sadatsafavi, Camille Taillé, Carlos A Torres-Duque, Ming-Ju Tsai, Charlotte S Ulrik, John W Upham, Anna von Bülow, Eileen Wang, Michael E Wechsler, David B Price
BACKGROUND: Biologic effectiveness is often assessed as 'response', a term which eludes consistent definition. Identifying those most likely to respond in real-life has proven challenging. OBJECTIVE: To explore definitions of biologic responders in adults with severe asthma and investigate patient characteristics associated with biologic response. METHODS: This was a longitudinal cohort study using data from 21 countries, which shared data with the International Severe Asthma Registry...
May 18, 2024: Journal of Allergy and Clinical Immunology in Practice
Joan B Soriano, Francesca Polverino
CONTEXT: Sex and gender are related concepts, but they have distinct meanings and implications. Respiratory diseases are a major driver of morbi-mortality. It is frequent that respirologists, primary care doctors, or other specialists, when dealing with respiratory patients, and aiming for a holistic management of their patients, they all skip any question or matter associated with sexual activity or behavior. OBJECTIVES: To review how sexual activity is explored in respiratory patients...
May 18, 2024: Respiratory Medicine
Ernani F Choma, Lisa A Robinson, Kari C Nadeau
Electric school buses have been proposed as an alternative to reduce the health and climate impacts of the current U.S. school bus fleet, of which a substantial share are highly polluting old diesel vehicles. However, the climate and health benefits of electric school buses are not well known. As they are substantially more costly than diesel buses, assessing their benefits is needed to inform policy decisions. We assess the health benefits of electric school buses in the United States from reduced adult mortality and childhood asthma onset risks due to exposure to ambient fine particulate matter (PM2...
May 28, 2024: Proceedings of the National Academy of Sciences of the United States of America
Tehmina Ahmad, Leighton Schreyer, Raymond Fung, Catherine Yu
BACKGROUND: Transgender people encounter significant barriers when seeking timely, high-quality healthcare, resulting in unmet medical needs with increased rates of diabetes, asthma, chronic obstructive pulmonary disease, and HIV. The paucity of postgraduate medical education to invest in standardization of transgender health training sustains these barriers, leaving physicians feeling unprepared and averse to provide transgender health care. Closing this education gap and improving transgender healthcare necessitates the development of consensus-built transgender health objectives of training (THOOT), particularly in Adult Endocrinology and Metabolism Residency programs...
2024: PloS One
Shufang Li, Junjun Dong, Aijun Li, Qiuyan Yang, Xiaoman Xiong, Xueli Xie, Yanli Zhang
OBJECTIVE: To investigate the role of 14-3-3β in acute asthma exacerbations in children and analyze the risk factors for asthma exacerbations. METHODS: This study recruited 101 children with acute asthma exacerbations, 101 children with stable asthma, and 65 healthy children. Serum 14-3-3β was compared among the three groups. Factors such as asthma family history, skin prick test, serum-specific IgE test, coinfections, and clinical indicators (FeNO, FEV1, white blood cells, eosinophils, and serum IgE level) were compared between the asthma groups...
May 20, 2024: Journal of Asthma
Raja Dhar, Deepak Talwar, Devasahayam J Christopher, Harjit Dumra, Parvaiz A Koul, Prashant N Chhajed, Sushmita Roychowdhury, Padmanabhan Arjun, Randeep Guleria
Objective In this document, 9 Indian experts have evaluated the factors specific to LMICs when it came to Severe Asthma (SA) diagnosis, evaluation, biologic selection, non-biologic treatment options and follow-up. Data Sources A search was performed using 50 keywords., focusing on the Indian/LMICs perspective, in PubMed, Cochrane Library, and Google Scholar. The key areas of the search were focused on diagnosis, phenoendotyping, non-biological therapies, selecting a biologic, assessment of treatment response and management of exacerbation...
May 20, 2024: Journal of Asthma
Shawn D Aaron, Katherine L Vandemheen, G Alex Whitmore, Celine Bergeron, Louis-Philippe Boulet, Andréanne Côté, R Andrew McIvor, Erika Penz, Stephen K Field, Catherine Lemière, Irvin Mayers, Mohit Bhutani, Tanweer Azher, M Diane Lougheed, Samir Gupta, Nicole Ezer, Christopher J Licskai, Paul Hernandez, Martha Ainslie, Gonzalo G Alvarez, Sunita Mulpuru
BACKGROUND: Many persons with chronic obstructive pulmonary disease (COPD) or asthma have not received a diagnosis, so their respiratory symptoms remain largely untreated. METHODS: We used a case-finding method to identify adults in the community with respiratory symptoms without diagnosed lung disease. Participants who were found to have undiagnosed COPD or asthma on spirometry were enrolled in a multicenter, randomized, controlled trial to determine whether early diagnosis and treatment reduces health care utilization for respiratory illness and improves health outcomes...
May 19, 2024: New England Journal of Medicine
Yingying Zhang, Yiting Wu, Xue Zhang, Chengjian Lv, Jingwang Lin, Lei Zhao, Yanmei Lin, Min Zhang, Wuping Bao
OBJECTIVE: To assess the diurnal rhythm and variability of lung function in healthy individuals, encompassing both large and small airways. METHODS: A prospective study enrolled 35 healthy adults without a history of smoking. Initial spirometry and a bronchodilation test were performed using the Jaeger spirometer, followed by a seven-day continuous home monitoring using the GOSPT2000. We evaluated repeatability using the intraclass correlation coefficient and agreement through linear regression and Bland-Altman analyses...
2024: Digital Health
Qiannan Fang, Wenbin Wu, Zexiu Xiao, Donglan Zeng, Rongzhen Liang, Julie Wang, Jia Yuan, Wenru Su, Xiang Xu, Yue Zheng, Tianwen Lai, Jianbo Sun, Qingling Fu, Song Guo Zheng
Allergic asthma is a chronic non-communicable disease characterized by lung tissue inflammation. Current treatments can alleviate the clinical symptoms to some extent, but there is still no cure. Recently, the transplantation of mesenchymal stem cells (MSCs) has emerged as a potential approach for treating allergic asthma. Gingival-derived mesenchymal stem cells (GMSCs), a type of MSC recently studied, have shown significant therapeutic effects in various experimental models of autoimmune diseases. However, their application in allergic diseases has yet to be fully elucidated...
May 17, 2024: IScience
Dailin Yuan, Yufei Bao, Ahmed El-Hashash
Recent studies demonstrated that mesenchymal stem cells (MSCs) are important for the cell-based therapy of diseased or injured lung due to their immunomodulatory and regenerative properties as well as limited side effects in experimental animal models. Preclinical studies have shown that MSCs have also a remarkable effect on the immune cells, which play major roles in the pathogenesis of multiple lung diseases, by modulating their activity, proliferation, and functions. In addition, MSCs can inhibit both the infiltrated immune cells and detrimental immune responses in the lung and can be used in treating lung diseases caused by a virus infection such as Tuberculosis and SARS-COV-2...
2024: American Journal of Stem Cells
Marta Paolucci, Nathalie Antz, Valentine Homère, Isabel Kolm, Thomas M Kündig, Pål Johansen
OBJECTIVES: Peanut allergy is an IgE-mediated food allergy that is associated with asthma in certain patients. With increasing prevalence, its great impact on the quality of life, and a lack of treatment options, the need for new therapy options is a given. Hence, models for research and development are required. This study aimed to establish a murine model of allergic airway inflammation induced by peanut allergens. METHODS: C3H mice were sensitised by intraperitoneal injections of peanut allergen extract and challenged by an intranasal application of the same extract...
2024: Front Allergy
Xianghe Meng, Yi Wang, Zhuqing Li, Fan Yang, Ji Wang
In this study, bibliometric analysis was carried out to comprehend the global research trends, hotspots, scientific frontiers, and output characteristics of the links between dendritic cells (DCs) and allergic diseases from 2004 to 2023. Publications and their recorded information were retrieved from the Web of Science Core Collection (WoSCC). VOSviewer and Citespace were used to visualize the hotspots and trends of research area. ChemBio 3D, Autodock tools, and Discovery Studio were used to visualize the molecular docking results of hotspots...
May 30, 2024: Heliyon
Mostafa A Abdel-Maksoud, Mostafa A Askar, Ibrahim Y Abdel-Rahman, Mustafa Gharib, Mohammed Aufy
BACKGROUND: Rheumatoid arthritis (RA) is considered a notable prolonged inflammatory condition with no proper cure. Synovial inflammation and synovial pannus are crucial in the onset of RA. The "tumor-like" invading proliferation of new arteries is a keynote of RA. Commiphora wightii ( C wightii ) is a perennial, deciduous, and trifoliate plant used in several areas of southeast Asia to cure numerous ailments, including arthritis, diabetes, obesity, and asthma. Several in vitro investigations have indicated C wightii's therapeutic efficacy in the treatment of arthritis...
2024: Bioinformatics and Biology Insights
Thomas Le Menestrel, Erin Craig, Robert Tibshirani, Trevor Hastie, Manuel Rivas
Recent genome-wide association studies (GWAS) have uncovered the genetic basis of complex traits, but show an under-representation of non-European descent individuals, underscoring a critical gap in genetic research. Here, we assess whether we can improve disease prediction across diverse ancestries using multiomic data. We evaluate the performance of Group-LASSO INTERaction-NET (glinternet) and pretrained lasso in disease prediction focusing on diverse ancestries in the UK Biobank. Models were trained on data from White British and other ancestries and validated across a cohort of over 96,000 individuals for 8 diseases...
May 7, 2024: ArXiv
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