Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
Alysha S Ismail, Brandon A Berryhill, Teresa Gil-Gil, Joshua A Manuel, Andrew P Smith, Fernando Baquero, Bruce R Levin
The rational design of the antibiotic treatment of bacterial infections employs these drugs to reach concentrations that exceed the minimum needed to prevent the replication of the target bacteria. However, within a treated patient, spatial and physiological heterogeneity promotes antibiotic gradients such that the concentration of antibiotics at specific sites is below the minimum needed to inhibit bacterial growth. Here, we investigate the effects of sub-inhibitory antibiotic concentrations on three parameters central to bacterial infection and the success of antibiotic treatment, using in vitro experiments with Staphylococcus aureus and mathematical-computer simulation models...
April 1, 2024: bioRxiv
#2
JOURNAL ARTICLE
Bruce R Levin, Brandon A Berryhill, Teresa Gil-Gil, Joshua A Manuel, Andrew P Smith, Jacob E Choby, Dan I Andersson, David S Weiss, Fernando Baquero
Antibiotics are considered one of the most important contributions to clinical medicine in the last century. Due to the use and overuse of these drugs, there have been increasing frequencies of infections with resistant pathogens. One form of resistance, heteroresistance, is particularly problematic; pathogens appear sensitive to a drug by common susceptibility tests. However, upon exposure to the antibiotic, resistance rapidly ascends, and treatment fails. To quantitatively explore the processes contributing to the emergence and ascent of resistance during treatment and the waning of resistance following cessation of treatment, we develop two distinct mathematical and computer-simulation models of heteroresistance...
April 16, 2024: Proceedings of the National Academy of Sciences of the United States of America
#3
JOURNAL ARTICLE
Paula Rodríguez-Molino, Araceli González Sánchez, Antoni Noguera-Julián, Aleix Soler-García, Patricia Martínez Paz, Ana Méndez-Echevarría, Fernando Baquero-Artigao, Miguel González Muñoz, María Jesús Ruíz-Serrano, Manuel Monsonís, Rocío Sánchez León, Jesús Saavedra-Lozano, Begoña Santiago-García, Talía Sainz
We analyzed 136 children with tuberculosis disease or infection and a positive QuantiFERON-TB (QFT) assay, followed-up for a median of 21 months (0.4-11years). QFT reversed in 16.9% of cases, with significant decreases in TB1 (-1.72 vs . -0.03 IU/ml, p=0.001) and TB2 (-1.65 vs . -0.43 IU/ml, p=0.005) levels compared to non-reverters. We found a higher QFT reversion rate among children under 5 years (25.0% vs 11.9%, p=0.042), and those with TST induration <15mm (29% vs 13.3%, p=0.055). Our data reveal that, although QFT test remained positive in the majority of children, reversion occurred in 16% of cases in a progressive and stable pattern...
2024: Frontiers in Immunology
#4
JOURNAL ARTICLE
Sonia Aracil-Gisbert, Miguel D Fernández-De-Bobadilla, Natalia Guerra-Pinto, Silvia Serrano-Calleja, Ana Elena Pérez-Cobas, Cruz Soriano, Raúl de Pablo, Val F Lanza, Blanca Pérez-Viso, Sandra Reuters, Henrik Hasman, Rafael Cantón, Fernando Baquero, Teresa M Coque
Serratia marcescens is an opportunistic pathogen historically associated with sudden outbreaks in intensive care units (ICUs) and the spread of carbapenem-resistant genes. However, the ecology of S. marcescens populations in the hospital ecosystem remains largely unknown. We combined epidemiological information of 1,432 Serratia spp. isolates collected from sinks of a large ICU that underwent demographic and operational changes (2019-2021) and 99 non-redundant outbreak/non-outbreak isolates from the same hospital (2003-2019) with 165 genomic data...
April 2, 2024: MBio
#5
JOURNAL ARTICLE
Teresa Del Rosal, Patricia Bote-Gascón, Iker Falces-Romero, Talía Sainz, Fernando Baquero-Artigao, Paula Rodríguez-Molino, Ana Méndez-Echevarría, Blanca Bravo-Queipo-de-Llano, Luis A Alonso, Cristina Calvo
Antibiotics are frequently prescribed to children with pneumonia, although viruses are responsible for most cases. We aimed to evaluate the impact of multiplex polymerase chain reaction (mPCR) on antibiotic use. We conducted a prospective study of children under 14 years of age admitted for suspected viral pneumonia, from October 2019 to June 2022 (except March-November 2020). A mPCR respiratory panel (FilmArray® 2 plus , bioMérieux, Marcy-l'Étoile, France) was performed within 72 h of admission...
February 15, 2024: Children
#6
JOURNAL ARTICLE
Borja Guarch-Ibáñez, Clara Carreras-Abad, Maria Antoinette Frick, Daniel Blázquez-Gamero, Fernando Baquero-Artigao, Isabel Fuentes-Corripio, Pere Soler-Palacin
INTRODUCTION: Currently, the status of serological screening for toxoplasmosis in pregnant women in Spain is unknown, and there is no official recommendation. The objective of this study is to show the current practice of gestational screening for toxoplasmosis in hospitals belonging to the Spanish Network for Research on Congenital Toxoplasmosis (REIV-TOXO). METHODS: An electronic survey was sent between April 2021 and September 2021 to investigators from 118 hospitals of REIV-TOXO, representing all Spanish regions...
January 30, 2024: Enfermedades infecciosas y microbiologia clinica
#7
REVIEW
Fernando Baquero, Jerónimo Rodríguez-Beltrán, Teresa M Coque, Rosa Del Campo
The acquisition and expression of antibiotic resistance implies changes in bacterial cell physiology, imposing fitness costs. Many human opportunistic pathogenic bacteria, such as those causing urinary tract or bloodstream infections, colonize the gut. In this opinionated review, we will examine the various types of stress that these bacteria might suffer during their intestinal stay. These stresses, and their compensatory responses, probably have a fitness cost, which might be additive to the cost of expressing antibiotic resistance...
January 8, 2024: Biomolecules
#8
JOURNAL ARTICLE
Marcelino Campos, Juan Carlos Galán, Mario Rodríguez-Domínguez, José M Sempere, Carlos Llorens, Fernando Baquero
The epidemiology of sexually transmitted infections (STIs) is complex and significantly influences sexual and reproductive health worldwide. Gender, age, sexual orientation, sexual behavior (including recreational drug use and physical and pharmacological protection practices), the structure of sexual contact networks, and the limited application or efficiency of diagnostic screening procedures create variable landscapes in different countries. Modeling techniques are required to deal with such complexity. We propose the use of a simulation technology based on membrane computing, mimicking in silico STI epidemics under various local conditions with an unprecedented level of detail...
January 10, 2024: Microbiology Spectrum
#9
REVIEW
Fernando Baquero, Konstantinos Beis, David J Craik, Yanyan Li, A James Link, Sylvie Rebuffat, Raúl Salomón, Konstantin Severinov, Séverine Zirah, Julian D Hegemann
Covering: 1992 up to 2023Since their discovery, lasso peptides went from peculiarities to be recognized as a major family of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products that were shown to be spread throughout the bacterial kingdom. Microcin J25 was first described in 1992, making it one of the earliest known lasso peptides. No other lasso peptide has since then been studied to such an extent as microcin J25, yet, previous review articles merely skimmed over all the research done on this exceptional lasso peptide...
January 2, 2024: Natural Product Reports
#10
JOURNAL ARTICLE
Fernando Baquero, Jerónimo Rodríguez-Beltrán, Bruce R Levin
This year we commemorate the centennial of the birth of the mature concept of bacteriostasis by John W. Churchman at Cornell University Medical School. The term bacteriostasis has primarily been applied to antibiotics (bacteriostatic antibiotics). In this Opinion paper, we are revisiting this concept by suggesting that some antibiotics are drugs that induce bacteria to become bacteriostatic. Cells that are unable to multiply, thereby preventing the antibiotic from exerting major lethal effects on them, are a variant ("different") type of cells, bacteriostatic cells...
December 21, 2023: MBio
#11
JOURNAL ARTICLE
Raquel Villar-Hernández, Irene Latorre, Antoni Noguera-Julian, Aina Martínez-Planas, Laura Minguell, Teresa Vallmanya, María Méndez, Antoni Soriano-Arandes, Fernando Baquero-Artigao, Paula Rodríguez-Molino, Sara Guillén-Martín, Carlos Toro-Rueda, M Luiza De Souza-Galvão, M Ángeles Jiménez-Fuentes, Zoran Stojanovic, Josefina Sabriá, José Ramón Santos, Jordi Puig, Marisol Domínguez-Álvarez, Joan-Pau Millet, Neus Altet, Yolanda Galea, Beatriz Muriel-Moreno, Esther García-García, Marc Bach-Griera, Cristina Prat-Aymerich, Esther Julián, Jordi B Torrelles, Carlos Rodrigo, José Domínguez
BACKGROUND: Diagnosis of nontuberculous mycobacteria (NTM) infections remains a challenge. In this study, we describe the evaluation of an immunological NTM-interferon (IFN)-γ release assay (IGRA) that we developed using glycopeptidolipids (GPLs) as NTM-specific antigens. METHODS: We tested the NTM-IGRA in 99 samples from pediatric patients. Seventy-five were patients with lymphadenitis: 25 were NTM confirmed, 45 were of unknown etiology but compatible with mycobacterial infection and 5 had lymphadenitis caused by an etiologic agent other than NTM...
December 18, 2023: Pediatric Infectious Disease Journal
#12
JOURNAL ARTICLE
María Ríos-Barnés, Eneritz Velasco-Arnaiz, Clàudia Fortuny, Marta Benavides, Fernando Baquero-Artigao, Oihana Muga, Rut Del Valle, Marie Antoinette Frick, Xavier Bringué, Susana Herrero, Javier Vilas, Almudena Alonso-Ojembarrena, Laura Castells-Vilella, Pablo Rojo, Daniel Blázquez-Gamero, Cristina Esteva, Emilia Sánchez, Ana Alarcón, Antoni Noguera-Julian
BACKGROUND: We aimed to determine the prevalence and severity of glomerular and tubular renal dysfunction by means of urinalysis in infants and toddlers with congenital cytomegalovirus infection (cCMV) and their association with cCMV disease, viruria and antiviral treatment. METHODS: This cross-sectional study was done using the Spanish Registry of Congenital Cytomegalovirus Infection. First-morning urine samples were collected from January 2016 to December 2018 from patients <5 years old enrolled in Spanish Registry of Congenital Cytomegalovirus Infection...
March 1, 2024: Pediatric Infectious Disease Journal
#13
JOURNAL ARTICLE
Marcela Gurgel, Maria Antonia Alvarez, Juan Fernando Aristizabal, Baptiste Baquero, Maxine Gillot, Najla Al Turkestani, Felicia Miranda, Aron Aliaga-Del Castillo, Jonas Bianchi, Antonio Carlos de Oliveira Ruellas, Marcos Ioshida, Marilia Yatabe, Diego Rey, Juan Prieto, Lucia Cevidanes
OBJECTIVE(S): This study aims to evaluate the influence of the piezocision surgery in the orthodontic biomechanics, as well as in the magnitude and direction of tooth movement in the mandibular arch using novel artificial intelligence (AI)-automated tools. MATERIALS AND METHODS: Nineteen patients, who had piezocision performed in the lower arch at the beginning of treatment with the goal of accelerating tooth movement, were compared to 19 patients who did not receive piezocision...
November 27, 2023: Orthodontics & Craniofacial Research
#14
Teresa Gil-Gil, Brandon A Berryhill, Joshua A Manuel, Andrew P Smith, Ingrid C McCall, Fernando Baquero, Bruce R Levin
Traditionally, bacteriostatic antibiotics are agents able to arrest bacterial growth. Despite being unable to kill bacterial cells, when they are used clinically the outcome of these drugs is frequently as effective as when a bactericidal drug is used. We explore the dynamics of Escherichia coli after exposure to two ribosome-targeting bacteriostatic antibiotics, chloramphenicol and azithromycin, for thirty days. The results of our experiments provide evidence that bacteria exposed to these drugs replicate, evolve, and generate a sub-population of small colony variants (SCVs) which are resistant to multiple drugs...
October 30, 2023: bioRxiv
#15
JOURNAL ARTICLE
Yamile Jubiz Pacheco, Enfermera Lady Nieto Marin, Dora Bernal Ocampo, Carmen Beatriz Baquero Gutiérrez, Gustavo Adolfo Marquez Salom, Jaime Brugés Ruiz, Gary Fernando Monclou Garzon, John Jairo Perez Casado, Iván Mauricio Hernández Agudelo, Juan Angel Vásquez Mendez, Enfermera Hilsen Duran Lopez, Ulises Múnera Bohorquez, Damaris Romero Chamorro, Alexandra Otero Carrascal, Emerson Barajas Suarez, Windy Cole, Thomas Serena, Camilo Acosta Marquez, Emma Woodmansey
INTRODUCTION: Oxygen is pivotal for wound healing. Its lack or hypoxia can delay this process, especially in individuals with comorbidities, potentially resulting in complex or hard-to-heal wounds. The Colombian Association of Diabetes (ACD) and the Colombian Association of Internal Medicine (ACMI) collaborated with a diverse group of experts to provide recommendations on the efficacy and best practices of continuous transdermal oxygen therapy (TOTc) in the care of such wounds. METHOD: A modified Delphi technique was employed to obtain controlled feedback and responses...
October 2, 2023: Journal of Wound Care
#16
Bruce R Levin, Brandon A Berryhill, Teresa Gil-Gil, Joshua A Manuel, Andrew P Smith, Jacob E Choby, Dan I Andersson, David S Weiss, Fernando Baquero
SUMMARY: Background: Antibiotics are considered one of the most important contributions to clinical medicine in the last 100 years. As a consequence of the use and overuse of these drugs, there have been increasing frequencies of infections with resistant pathogens. One form of resistance, heteroresistance, is particularly problematic; pathogens appear sensitive to a drug by commonly used susceptibility tests. However, upon exposure to the antibiotic, resistance rapidly ascends, and treatment fails...
September 21, 2023: bioRxiv
#17
JOURNAL ARTICLE
Julián Andres Romo, Carlos Edgar Figueroa Avendaño, Laura A López, Natalia Mesa, Alejandro González-Muñoz, David Baquero, Andrea Recamán, Fernando Rabeya, Alejandro Villabon, Isabella Velandia Sánchez, Álvaro Flechas
Rectal cancer is an increasing disease worldwide. The outcomes of its treatment are related to the preoperative characteristics of the patient. The objective of this study was to describe sociodemographic, clinical and surgical characteristics and outcomes of patients operated on for rectal cancer at Hospital Universitario Mayor Méderi (HUM) during the period within 2013-2017.A retrospective descriptive cohort-type study was carried out by consulting the clinical records of patients above the age of 18 years with a clinical/histopathological diagnosis of rectal cancer and an institutional follow-up in those who underwent surgery with laparoscopic anterior resection of the rectum carried out by the coloproctology service of the HUM between 2013 and 2017...
September 8, 2023: Scientific Reports
#18
JOURNAL ARTICLE
Carlos Grasa, Einés Monteagudo-Vilavedra, Elena Pérez-Arenas, Iker Falces-Romero, Yasmina Mozo Del Castillo, Cristina Schüffelmann-Gutiérrez, Teresa Del Rosal, Ana Méndez-Echevarría, Fernando Baquero-Artigao, Alejandro Zarauza Santoveña, Pilar Serrano Fernández, Talía Sainz, Cristina Calvo
BACKGROUND: human adenovirus (hAdV) infection constitutes an important cause of morbidity and mortality in transplant recipients, due to their immune status. Among drugs currently available, cidofovir (CDF) is the most prescribed. METHODS: Retrospective study of hAdV infection in paediatric transplant recipients from a tertiary paediatric centre, describing characteristics, management, and outcomes, and focused on the role of CDF. RESULTS: 49 episodes of infection by hAdV were detected during a four-year period: 38 episodes in patients that received allogeneic hematopoietic stem cell transplantation (77...
July 4, 2023: Microorganisms
#19
JOURNAL ARTICLE
Xavier Sáez-Llorens, Ximena Norero, Marisa Márcia Mussi-Pinhata, Kathia Luciani, Ignacio Salamanca de la Cueva, Javier Díez-Domingo, Eduardo Lopez-Medina, Cristina Epalza, Jerzy Brzostek, Henryk Szymański, François D Boucher, Benhur S Cetin, Tirza De Leon, Ener Cagri Dinleyici, Miguel Ángel Marín Gabriel, Tolga Ince, Mercedes Macias-Parra, Joanne M Langley, Federico Martinón-Torres, Mika Rämet, Ernest Kuchar, Jorge Pinto, Thanyawee Puthanakit, Fernando Baquero-Artigao, Guido Castelli Gattinara, Jose Manuel Merino Arribas, Jose Tomas Ramos Amador, Leszek Szenborn, Bruce Tapiero, Evan J Anderson, James D Campbell, Saul N Faust, Vanja Nikic, Yingjun Zhou, Wenji Pu, Damien Friel, Ilse Dieussaert, Antonio Gonzalez Lopez, Roderick McPhee, Sonia K Stoszek, Nicolas Vanhoutte
BACKGROUND: Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections in infants. This phase 1/2, observer-blind, randomized, controlled study (ClinicalTrials.gov/NCT03636906) assessed the safety and immunogenicity of an investigational chimpanzee-derived adenoviral vector RSV vaccine (ChAd155-RSV, expressing RSV F, N, and M2-1) in infants. METHODS: Healthy 6-7-month-olds were 1:1:1-randomized to receive: 1 low ChAd155-RSV dose (1...
July 21, 2023: Journal of Infectious Diseases
#20
REVIEW
José L Martínez, Fernando Baquero
As recognized by several international agencies, antibiotic resistance is nowadays one of the most relevant problems for human health. While this problem was alleviated with the introduction of new antibiotics into the market in the golden age of antimicrobial discovery, nowadays few antibiotics are in the pipeline. Under these circumstances, a deep understanding on the mechanisms of emergence, evolution and transmission of antibiotic resistance, as well as on the consequences for the bacterial physiology of acquiring resistance is needed to implement novel strategies, beyond the development of new antibiotics or the restriction in the use of current ones, to more efficiently treat infections...
July 7, 2023: Microbial Biotechnology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
