Ye Yuan, Qiuguang He, Xiao Yang, Jerry J Flores, Lei Huang, Xu Luo, Xingyu Zhang, Zongyi Zhang, Ruihao Li, Lingui Gu, Siyuan Dong, Shiyi Zhu, Kun Yi, Mingyang Han, Lei Wu, You Zhou, John H Zhang, Zongyi Xie, Jiping Tang
Germinal matrix hemorrhage (GMH) is a devasting neurological disease in premature newborns. After GMH, brain iron overload associated with hemoglobin degradation contributed to oxidative stress, causing disruption of the already vulnerable blood-brain barrier (BBB). Mitochondrial ferritin (FTMT), a novel mitochondrial outer membrane protein, is crucial in maintaining cellular iron homeostasis. We aimed to investigate the effect of FTMT upregulation on oxidative stress and BBB disruption associated with brain iron overload in rats...
April 2024: Experimental Neurology