Gabriel Quiñones Vélez, Lesly Carmona-Sarabia, Alexandra París Santiago, Angélica F Figueroa Guzmán, Chunhua Hu, Esther Peterson-Peguero, Vilmalí López-Mejías
Coordination of clinically employed bisphosphonate, risedronate (RISE), to bioactive metals, Ca2+ , Mg2+ , and Zn2+ , allowed the formation of bisphosphonate-based coordination complexes (BPCCs). Three RISE-based BPCCs, RISE-Ca, RISE-Mg, and RISE-Zn, were produced, and their structures were elucidated by single crystal X-ray diffraction. Interestingly, the addition of an auxiliary ligand, etidronic acid (HEDP), resulted in the recrystallized protonated form of the ligand, H-RISE. The pH-dependent structural stability of the RISE-based BPCCs was measured by means of dissolution profiles under neutral and acidic simulated physiological conditions (PBS and FaSSGF, respectively)...
March 20, 2023: ACS Applied Bio Materials