Nikita P Ilyin, Arslan D Nabiullin, Anna D Kozlova, Olga V Kupriyanova, Vadim A Shevyrin, Tatyana Gloriozova, Dmitry Filimonov, Alexey Lagunin, David S Galstyan, Tatiana O Kolesnikova, Mikael S Mor, Evgeniya V Efimova, Vladimir Poroikov, Konstantin B Yenkoyan, Murilo S de Abreu, Konstantin A Demin, Allan V Kalueff
Potently affecting human and animal brain and behavior, hallucinogenic drugs have recently emerged as potentially promising agents in psychopharmacotherapy. Complementing laboratory rodents, the zebrafish ( Danio rerio ) is a powerful model organism for screening neuroactive drugs, including hallucinogens. Here, we tested four novel N -benzyl-2-phenylethylamine (NBPEA) derivatives with 2,4- and 3,4-dimethoxy substitutions in the phenethylamine moiety and the -F, -Cl, and -OCF3 substitutions in the ortho position of the phenyl ring of the N -benzyl moiety (34H-NBF, 34H-NBCl, 24H-NBOMe(F), and 34H-NBOMe(F)), assessing their behavioral and neurochemical effects following chronic 14 day treatment in adult zebrafish...
April 29, 2024: ACS Chemical Neuroscience