Mingjie Sun, Yang Lu, Hongrui Zhang, Weiqian Jiang, Wenzhao Wang, Xiao Huang, Shichun Zhang, Dulei Xiang, Boyu Tang, Yu Chen, Tingmei Chen, Chengjie Lian, Jian Zhang
The management of infected bone defects poses a significant clinical challenge, and current treatment modalities exhibit various limitations. This study focuses on the development of a multifunctional composite scaffold comprising nanohydroxyapatite/polyethyleneglycol diacrylate (HP) matrix, silver nanoparticles (AgNPs), graphene oxide (GO), sodium alginate (SA), and M2-type macrophage membrane vesicles (MVs) to enhance the healing of infected bone defects. The composite scaffold demonstrates several key features: first, it releases sufficient quantities of silver ions to effectively eliminate bacteria; second, the controlled release of MVs leads to a notable increase in M2-type macrophages, thereby significantly mitigating the inflammatory response...
April 29, 2024: Advanced Healthcare Materials