Hui Liu, Kefei Wu, Wenting Hu, Xiaoxiao Chen, Yanjing Tang, Yani Ma, Changcheng Chen, Yangyang Xie, Lisha Yu, Jun Huang, Shuhong Shen, Xiang Wang
Acute myeloid leukaemia (AML) is a highly heterogeneous disease, exhibiting diverse subtypes according to the characteristics of tumour cells. The immunophenotype is one of the aspects acquired routinely through flow cytometry in the diagnosis of AML. Here, we characterized the antigen expression in paediatric AML cases across both morphological and molecular genetic subgroups. We discovered a subgroup of patients with unfavourable prognosis that can be immunologically characterized, irrespective of morphological FAB results or genetic aberrations...
April 19, 2024: British Journal of Haematology