Gaofei Li, Yicong Sun, Immanuel Kwok, Liting Yang, Wanying Wen, Peixian Huang, Mei Wu, Jing Li, Zhibin Huang, Zhaoyuan Liu, Shuai He, Wan Peng, Jin-Xin Bei, Florent Ginhoux, Lai Guan Ng, Yiyue Zhang
Eosinophils are a group of granulocytes well known for their capacity to protect the host from parasites and regulate immune function. Diverse biological roles for eosinophils have been increasingly identified, but the developmental pattern and regulation of the eosinophil lineage remain largely unknown. Herein, we utilize the zebrafish model to analyze eosinophilic cell differentiation, distribution, and regulation. By identifying eslec as an eosinophil lineage-specific marker, we establish a Tg(eslec:eGFP) reporter line, which specifically labeled cells of the eosinophil lineage from early life through adulthood...
January 27, 2024: Nature Communications