Veronica A Bahamondes Lorca, Oscar Ávalos-Ovando, Christoph Sikeler, Heini Ijäs, Eva Yazmin Santiago, Eli Skelton, Yong Wang, Ruiqi Yang, Katherine Leslee Asetre Cimatu, Olga Baturina, Zhewei Wang, Jundong Liu, Joseph M Slocik, Shiyong Wu, Dongling Ma, Andrei Pastukhov, Andrei V Kabashin, Martin E Kordesch, Alexander O Govorov
Nanoparticles (NPs) can be conjugated with diverse biomolecules and employed in biosensing to detect target analytes in biological samples. This proven concept was primarily used during the COVID-19 pandemic with gold-NP-based lateral flow assays (LFAs). Considering the gold price and its worldwide depletion, here we show that novel plasmonic NPs based on inexpensive metals, titanium nitride (TiN) and copper covered with a gold shell (Cu@Au), perform comparable to or even better than gold nanoparticles. After conjugation, these novel nanoparticles provided high figures of merit for LFA testing, such as high signals and specificity and robust naked-eye signal recognition...
May 13, 2024: Nano Letters