Jingyi Wu, Longfang Zhou, Yameng Liu, Xiaowei Zhang, Yuanhang Yang, Xinyuan Zhu, Qianwen Bu, Xinmiao Shan, Jia Yin, Robert N Weinreb, Qingjun Zhou, Xiaojing Pan, Alex S Huang
PURPOSE: To evaluate VEGF-C-induced lymphoproliferation in conjunction with 5-fluorouracil (5-FU) antimetabolite treatment in a rabbit glaucoma filtration surgery (GFS) model. METHODS: Thirty-two rabbits underwent GFS and were assigned to four groups (n = 8 each) defined by subconjunctival drug treatment: (a) VEGF-C combined with 5-FU, (b) 5-FU, (c) VEGF-C, (d) and control. Bleb survival, bleb measurements, and IOP were evaluated over 30 days. At the end, histology and anterior segment OCT were performed on some eyes...
May 1, 2024: Investigative Ophthalmology & Visual Science