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JOURNAL ARTICLE
Bárbara Lacerda Teixeira, Pedro Silva Cunha, Ana Sofia Jacinto, Guilherme Portugal, Sérgio Laranjo, Bruno Valente, Ana Lousinha, Madalena Coutinho Cruz, Ana Sofia Delgado, Manuel Brás, Margarida Paulo, Cátia Guerra, Ruben Ramos, Iládia Fontes, Rui Cruz Ferreira, Mário Martins Oliveira
INTRODUCTION: In patients with atrial fibrillation (AF), up to one third have recurrence after a first catheter ablation (CA). Epicardial adipose tissue (EAT) has been considered to be closely related to AF, with a potential role in its recurrence. We aimed to evaluate the association between the volume of EAT measured by cardiac computed tomography (CT) and AF recurrence after CA. METHODS: Consecutive AF patients underwent a standardized cardiac CT protocol for quantification of EAT, thoracic adipose volume (TAV) and left atrium (LA) volume before CA...
April 28, 2024: Clinical Imaging
#2
JOURNAL ARTICLE
Klara Komici, Leonardo Bencivenga, Caterina Arganese, Giuseppe Rengo, Germano Guerra
BACKGROUND: Muscular strength and muscle mass are considered key factors for healthy ageing. Modification of body composition and redistribution of adipose tissue has been described in advanced age. Muscle strength has an important predictive role for health outcomes. However, little is known regarding the relationship between muscle strength and epicardial fat. METHODS AND MATERIALS: In a cohort of healthy adults following physical capacity evaluations, anthropometric measurements, handgrip strength (HGS), echocardiography and bioimpedance analysis (BIA) were performed...
April 29, 2024: Experimental Gerontology
#3
JOURNAL ARTICLE
J L Ashton, B Prince, G Sands, L Argent, M Anderson, J E G Smith, A Tedoldi, A Ahmad, D Baddeley, A G Pereira, N Lever, T Ramanathan, B H Smaill, Johanna M Montgomery
Altered autonomic input to the heart plays a major role in atrial fibrillation (AF). Autonomic neurons termed ganglionated plexi (GP) are clustered on the heart surface to provide the last point of neural control of cardiac function. To date the properties of GP neurons in humans are unknown. Here we have addressed this knowledge gap in human GP neuron structure and physiology in patients with and without AF. Human right atrial GP neurons embedded in epicardial adipose tissue were excised during open heart surgery performed on both non-AF and AF patients and then characterised physiologically by whole cell patch clamp techniques...
April 30, 2024: Journal of Physiology
#4
JOURNAL ARTICLE
Marco Guglielmo, Marco Penso, Maria Ludovica Carerj, Carlo Maria Giacari, Alessandra Volpe, Laura Fusini, Andrea Baggiano, Saima Mushtaq, Andrea Annoni, Francesco Cannata, Francesco Cilia, Alberico Del Torto, Fabio Fazzari, Alberto Formenti, Antonio Frappampina, Paola Gripari, Daniele Junod, Maria Elisabetta Mancini, Valentina Mantegazza, Riccardo Maragna, Francesca Marchetti, Giorgio Mastroiacovo, Sergio Pirola, Luigi Tassetti, Francesca Baessato, Valentina Corino, Andrea Igoren Guaricci, Mark G Rabbat, Alexia Rossi, Chiara Rovera, Pietro Costantini, Ivo van der Bilt, Pim van der Harst, Marianna Fontana, Enrico G Caiani, Mauro Pepi, Gianluca Pontone
BACKGROUND AND AIMS: This study investigated the additional prognostic value of epicardial adipose tissue (EAT) volume for major adverse cardiovascular events (MACE) in patients undergoing stress cardiac magnetic resonance (CMR) imaging. METHODS: 730 consecutive patients [mean age: 63 ± 10 years; 616 men] who underwent stress CMR for known or suspected coronary artery disease were randomly divided into derivation (n = 365) and validation (n = 365) cohorts...
April 18, 2024: Atherosclerosis
#5
JOURNAL ARTICLE
Irshad Ahmad, Shreyan Gupta, Patricia Faulkner, Destiny Mullens, Micah Thomas, Sharanee P Sytha, Ivan Ivanov, James J Cai, Cristine L Heaps, Annie E Newell-Fugate
BACKGROUND: Coronary artery disease (CAD) is a leading cause of death in women. Epicardial adipose tissue (EAT) secretes cytokines to modulate coronary artery function, and the release of fatty acids from EAT serves as a readily available energy source for cardiomyocytes. However, despite having beneficial functions, excessive amounts of EAT can cause the secretion of proinflammatory molecules that increase the instability of atherosclerotic plaques and contribute to CAD progression. Although exercise mitigates CAD, the mechanisms by which exercise impacts EAT are unknown...
April 26, 2024: Cell Communication and Signaling: CCS
#6
JOURNAL ARTICLE
Murat Vural, Betül Akdal Dölek, Gülsüm Kılıçkap, Gülsüm Kübra Bahadır, Yasin Celal Güneş
BACKGROUND: Epicardial adipose tissue (EAT) volume is usually measured with ECG-gated computed tomography (CT). Measurement of EAT thickness is a more convenient method; however, it is not clear whether EAT thickness measured with non-gated CT is reliable and at which localization it agrees best with the EAT volume. PURPOSE: To examine the agreement between ECG-gated EAT volume and non-gated EAT thickness measured from various localizations and to assess the predictive role of EAT thickness for high EAT volume...
April 22, 2024: Acta Radiologica
#7
JOURNAL ARTICLE
Panteha Rezaeian, Jye-Yu C Backlund, Mohammed Zaveri, Rine Nakanishi, Suguru Matsumoto, Anas Alani, Aryabod Razipour, John M Lachin, Matthew Budoff
OBJECTIVE: Coronary artery, aortic valve, and descending aorta calcification (CAC, AVC, DAC) are manifestations of atherosclerosis, and cardiac epicardial adipose tissue (EAT) indicates heart adiposity. This study explored the association between cardiac adipose tissue and cardiovascular calcification in participants with long-standing T1D. METHODS: EAT and intra-thoracic adipose tissue (IAT) were measured in 100 T1D subjects with cardiac computed tomography (CT) scans in the EDIC study...
June 2024: American journal of preventive cardiology
#8
JOURNAL ARTICLE
Ayşe Bahar Keleşoğlu Dinçer, Haluk Furkan Şahan
Epicardial adipose tissue is a novel cardiometabolic risk factor and indicator of subclinical atherosclerosis. We aimed to evaluate the epicardial adipose tissue thickness in rheumatoid arthritis (RA) patients and its association with disease activity scores. A total of 81 rheumatoid arthritis patients and 70 age- and sex-matched healthy individuals were recruited for this cross-sectional study. Epicardial adipose tissue thickness (EATT) was measured by transthoracic two-dimensional echocardiography. Tender and swollen joint counts were recorded at the time of inclusion...
April 5, 2024: Internal and Emergency Medicine
#9
Ju-Wei Shao, Bing-Hua Chen, Kamil Abu-Shaban, Ahmad Baiyasi, Lian-Ming Wu, Jing Ma
BACKGROUND: Obesity has become a serious public health issue, significantly elevating the risk of various complications. It is a well-established contributor to Heart failure with preserved ejection fraction (HFpEF). Evaluating HFpEF in obesity is crucial. Epicardial adipose tissue (EAT) has emerged as a valuable tool for validating prognostic biomarkers and guiding treatment targets. Hence, assessing EAT is of paramount importance. Cardiovascular magnetic resonance (CMR) imaging is acknowledged as the gold standard for analyzing cardiac function and morphology...
March 26, 2024: World Journal of Cardiology
#10
JOURNAL ARTICLE
Hiroyuki Natsui, Masaya Watanabe, Takashi Yokota, Satonori Tsuneta, Yoshizuki Fumoto, Haruka Handa, Matsushima Shouji, Jiro Koya, Kotaro Nishino, Daishiro Tatsuta, Takuya Koizumi, Takahide Kadosaka, Motoki Nakao, Taro Koya, Taro Temma, Yoichi M Ito, Hatanaka C Kanako, Yutaka Hatanaka, Shingu Yasushige, Satoru Wakasa, Shuhei Miura, Takahiko Masuda, Naritomo Nishioka, Shuichi Naraoka, Kayoko Ochi, Tomoko Kudo, Tsugumine Ishikawa, Toshihisa Anzai
Epicardial adipose tissue (EAT) is an active endocrine organ that is closely associated with occurrence of atrial fibrillation (AF). However, the role of EAT in the development of postoperative AF (POAF) remains unclear. We aimed to investigate the association between EAT profile and POAF occurrence in patients who underwent cardiovascular surgery. We obtained EAT samples from 53 patients to evaluate gene expression, histological changes, mitochondrial oxidative phosphorylation (OXPHOS) capacity in the EAT, and protein secretion in EAT-conditioned medium...
March 2024: Physiological Reports
#11
JOURNAL ARTICLE
Takaaki Sato, Kunio Yufu, Hirochika Yamasaki, Taisuke Harada, Shuichiro Yamauchi, Yumi Ishii, Tomoko Fukuda, Takayuki Kawashima, Takashi Shuto, Hidefumi Akioka, Tetsuji Shinohara, Yasushi Teshima, Tomoyuki Wada, Shinji Miyamoto, Naohiko Takahashi
Epicardial adipose tissue (EAT) have been shown to be associated with several heart disease, including coronary artery disease (CAD), atrial fibrillation (AF), and heart failure (HF). It is reported that the quality of EAT, represented by fat attenuation determined using computed tomography (CT) imaging, can detect the histologically-assessed remodeled EAT. We tested the hypothesis that quality of EAT would predict major adverse cerebral and cardiovascular events (MACCE) following transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis (AS)...
March 19, 2024: Heart and Vessels
#12
JOURNAL ARTICLE
Minoru Nodera, Tomokazu Ishida, Kanae Hasegawa, Shota Kakehashi, Moe Mukai, Daisetsu Aoyama, Shinsuke Miyazaki, Hiroyasu Uzui, Hiroshi Tada
Epicardial adipose tissue (EAT) induces inflammation in the atria and is associated with atrial fibrillation (AF). Several studies have examined the relationship between EAT volume (EAT-V) and density (EAT-D) and the presence of AF after catheter ablation. However, conclusions have been inconsistent. This study included 43 consecutive patients who underwent catheter ablation for AF and 30 control patients. EAT-V and EAT-D around the entire heart, entire atrium, left atrium (LA), and right atrium (RA) were measured in detail using reconstructed three-dimensional (3D) EAT images from dual-source computed tomography (CT)...
March 18, 2024: Heart and Vessels
#13
JOURNAL ARTICLE
Joel T Rämö, Shinwan Kany, Cody R Hou, Samuel F Friedman, Carolina Roselli, Victor Nauffal, Satoshi Koyama, Juha Karjalainen, Mahnaz Maddah, Aarno Palotie, Patrick T Ellinor, James P Pirruccello
IMPORTANCE: Epicardial and pericardial adipose tissue (EPAT) has been associated with cardiovascular diseases such as atrial fibrillation or flutter (AF) and coronary artery disease (CAD), but studies have been limited in sample size or drawn from selected populations. It has been suggested that the association between EPAT and cardiovascular disease could be mediated by local or paracrine effects. OBJECTIVE: To evaluate the association of EPAT with prevalent and incident cardiovascular disease and to elucidate the genetic basis of EPAT in a large population cohort...
March 13, 2024: JAMA Cardiology
#14
JOURNAL ARTICLE
Aleksander Bogdański, Piotr Niziołek, Stanisław Kopeć, Małgorzata Moszak
Epicardial adipose tissue (EAT) is located between the heart muscle and visceral pericardium, where it has direct contact with coronary blood vessels. Elevated thickness of this tissue can induce local inflammation affecting the myocardium and the underlying coronary arteries, contributing to various cardiovascular diseases such as coronary artery disease, atrial fibrillation, or heart failure with preserved ejection fraction. Recent studies have identified EAT thickness as a simple and reliable biomarker for certain cardiovascular outcomes...
March 13, 2024: Cardiology in Review
#15
JOURNAL ARTICLE
Dan Zhang, Xin Tian, Meng-Ya Li, Hao-Wen Zhang, Yang Yu, Tong Pan, Cai-Ying Li
We performed this cohort study to investigate whether the myocardial bridge (MB) affects the fat attenuation index (FAI) and to determine the optimal cardiac phase to measure the volume and the FAI of pericoronary adipose tissue (PCAT). The data of 300 patients who were diagnosed with MB of the left anterior descending (LAD) coronary artery were retrospectively analyzed. All of patients were divided into the MB group and the MB with atherosclerosis group. In addition, 104 patients with negative CCTA results were enrolled as the control group...
March 12, 2024: Scientific Reports
#16
JOURNAL ARTICLE
Zheng Wang, Zengfa Huang, Xiang Wang
BACKGROUND: Epicardial Adipose Tissue (EAT) accumulation is closely associated with the presence and severity of coronary artery disease (CAD), myocardial ischemia, plaque vulnerability, and major adverse cardiovascular events. OBJECTIVE: The aim of this study was to investigate the correlation between myocardial ischemia defined by computed tomography-derived fractional flow reserve (CT-FFR) and region-specific EAT in patients with type 2 diabetes mellitus (T2DM)...
February 28, 2024: Current medical imaging
#17
JOURNAL ARTICLE
Yoran Crum, Elke S Hoendermis, Dirk J van Veldhuisen, Gijs van Woerden, Michelle Lobeek, Michael G Dickinson, Laura M G Meems, Adriaan A Voors, Michiel Rienstra, Thomas M Gorter
AIMS: Obesity and epicardial adiposity play a role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF), and both are associated with increased filling pressures and reduced exercise capacity. The haemodynamic basis for these observations remains inaccurately defined. We hypothesize that an abundance of epicardial adipose tissue (EAT) within the pericardial sac is associated with haemodynamic signs of pericardial constraint. METHODS AND RESULTS: HFpEF patients who underwent invasive heart catheterization with simultaneous echocardiography were included...
March 4, 2024: ESC Heart Failure
#18
JOURNAL ARTICLE
B F Ozturk Ceyhan
OBJECTIVE: The female population with gestational diabetes mellitus (GDM) has a postpartum profile with increased cardiovascular (CV) risk factors and heightened prospective CV risk. Epicardial fat tissue was reported to be related to cardiometabolic diseases as metabolically active adipose tissue and natriuretic peptides (NPs) have been shown to have metabolic effects. This study's aim was to determine the relationship between epicardial fat thickness (EFT) and NPs in the female population diagnosed with GDM...
February 2024: European Review for Medical and Pharmacological Sciences
#19
JOURNAL ARTICLE
Pamela Piña, Daniel Lorenzatti, Francesco Castagna, Jeremy Miles, Toshiki Kuno, Andrea Scotti, Javier Arce, Ari Feinberg, Dou Huang, Jake Gilman, Ephraim Leiderman, Jonathan Daich, Paul Ippolito, Carlos A Gongora, Aldo L Schenone, Lili Zhang, Carlos J Rodriguez, Michael J Blaha, Damini Dey, Daniel S Berman, Salim S Virani, Jeffrey M Levsky, Mario J Garcia, Leandro Slipczuk
BACKGROUND: Coronary artery calcium (CAC), thoracic aorta calcification (TAC), non-alcoholic fatty liver disease (NAFLD), and epicardial adipose tissue (EAT) are associated with atherosclerotic cardiovascular disease (ASCVD) and heart failure (HF). OBJECTIVES: We aimed to determine whether these cardiometabolic and atherosclerotic risk factors identified by non-contrast chest computed tomography (CT) are associated with HF hospitalizations in patients with LDL-C≥ 190 mg/dL...
February 7, 2024: Journal of Clinical Lipidology
#20
JOURNAL ARTICLE
Ling Kuo, Guan-Jie Wang, Shih-Ling Chang, Yenn-Jiang Lin, Fa-Po Chung, Li-Wei Lo, Yu-Feng Hu, Tze-Fan Chao, Ta-Chuan Tuan, Jo-Nan Liao, Ting-Yung Chang, Chin-Yu Lin, Chih-Min Liu, Shin-Huei Liu, Ming-Ren Kuo, Guan-Yi Li, Yu-Shan Huang, Cheng-I Wu, Shih-Ann Chen, Chia-Feng Lu
BACKGROUND: The aim of this study was to build an auto-segmented artificial intelligence model of the atria and epicardial adipose tissue (EAT) on computed tomography (CT) images, and examine the prognostic significance of auto-quantified left atrium (LA) and EAT volumes for AF.Methods and Results: This retrospective study included 334 patients with AF who were referred for catheter ablation (CA) between 2015 and 2017. Atria and EAT volumes were auto-quantified using a pre-trained 3-dimensional (3D) U-Net model from pre-ablation CT images...
February 14, 2024: Circulation Journal: Official Journal of the Japanese Circulation Society
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