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JOURNAL ARTICLE
C B van den Berg, S Dasgupta, P C Ewing-Graham, J Bart, J Bulten, K N Gaarenstroom, J A de Hullu, C H Mom, M J E Mourits, M P Steenbeek, R van Marion, H J van Beekhuizen
OBJECTIVE: The majority of high-grade serous carcinomas (HGSC) of the ovary, fallopian tube, and peritoneum arise from the precursor lesion called serous tubal intraepithelial carcinoma (STIC). It has been postulated that cells from STICs exfoliate into the peritoneal cavity and give rise to peritoneal HGSC several years later. While co-existent STICs and HGSCs have been reported to share similarities in their mutational profiles, clonal relationship between temporally distant STICs and HGSCs have been infrequently studied and the natural history of STICs remains poorly understood...
May 16, 2024: Gynecologic Oncology
#2
JOURNAL ARTICLE
Shotaro Higuchi, Tsutomu Miyamoto, Kenji Oka, Hisanori Kobara, Tanri Shiozawa
BACKGROUND: Despite the recent progress of fertility preservation technique, achievement of pregnancy in women with ovarian tumor is still challenging. Here, we report a case of OTO-IVM (ovarian tissue oocyte in-vitro maturation) resulting in a successful delivery. CASE PRESENTATION: The patient, a 33-year-old woman with a history of left borderline ovarian tumor (BOT) who underwent left salpingo-oophorectomy three years ago, presented with an enlarged right ovary during infertility treatment, indicating the recurrence of BOT...
May 16, 2024: Contraception and Reproductive Medicine
#3
REVIEW
Junaid Anwar, Ahmed Abdelhakeem, Muhammad Shariq Khan, Hafiz Muhammad Arslan, Juwairiya Shuroog, Zouina Sarfraz, Ali Saeed, Anwaar Saeed
BACKGROUND: Stage IV gastric cancer patients with Krukenberg tumors typically exhibit poor survival outcomes, often less than 2 years. The management of this tumor subgroup remains non-standardized, and the impact of oophorectomy on survival remains uncertain. In this study, we systematically analyzed survival outcomes among gastric cancer patients with ovarian metastases who underwent standard chemotherapy, surgical resection of ovarian metastases, or combined chemotherapy and surgery...
May 15, 2024: Journal of Gastrointestinal Cancer
#4
REVIEW
Yuge Chen, Fengjuan Li, Lei Liang, Huiling Hua, Shizheng Liu, Zihe Yu, Qiuyu Chen, Shufeng Huang, Pei Qin
BACKGROUND: The associations between hysterectomy and cardiovascular disease (CVD) and mortality remains unlcear and a meta-analysis with cohort studies is lacking. OBJECTIVES: This study aimed to conduct a systematic review and meta-analysis of cohort studies to investigate the relationship between hysterectomy and CVD, coronary heart disease (CHD), stroke, heart failure, and all-cause, cardiovascular and cancer mortality. We further explored the effect of oophorectomy on the association between hysterectomy and these health outcomes...
May 15, 2024: BJOG: An International Journal of Obstetrics and Gynaecology
#5
Samia Tligui, Hounaida Mahfoud, Samia Sassi, Hanane Inrhaoun, Najat Lamalmi, Fatima El Hassouni, Samir Bargach
Torsion occurs as a complication in 10% of cases of ovarian tumors. It predominantly occurs in benign ones, while malignant tumors are less prone to torsion. Sertoli-Leydig cell tumors are highly unusual sex cord-stromal tumors of the ovary, accounting for less than 0.2% of all ovarian cancers. A 39-year-old patient presented to the emergency department with a Sertoli-Leydig cell tumor diagnosed due to ovarian torsion. The clinical presentation was characterized by abdominal pain. Ultrasound indicated signs of torsion, and torsion of the right ovary was subsequently confirmed during laparotomy...
June 2024: Case Reports in Women's Health
#6
JOURNAL ARTICLE
Mamta M Mamik, Shunaha Kim-Fine, Linda Yang, Vidya Sharma, Rajiv Gala, Sarit Aschkenazi, David Sheyn, David Howard, Andrew J Walter, Bela Kudish, Ethan M Balk, Danielle D Antosh
OBJECTIVE: To identify the optimal hysterectomy approach for large uteri in gynecologic surgery for benign indications from a perioperative morbidity standpoint. DATA SOURCES: PubMed and Embase databases were searched from inception through September 19, 2022. Meta-analyses were conducted as feasible. METHODS OF STUDY SELECTION: This review included studies that compared routes of hysterectomy with or without bilateral salpingo-oophorectomy for large uteri (12 weeks or more or 250 g or more) and excluded studies with any concurrent surgery for pelvic organ prolapse, incontinence, gynecologic malignancy, or any obstetric indication for hysterectomy...
May 15, 2024: Obstetrics and Gynecology
#7
Donato Cannoletta, Antony Pellegrino, Greta Pettenuzzo, Matteo Pacini, Ruben Calvo Sauer, Juan R Torres-Anguiano, Luca Morgantini, Simone Crivellaro
INTRODUCTION: Vesicovaginal fistula (VVF) is the most common urogenital fistula due to iatrogenic cause, primarily associated with gynecologic surgery (1). Although both conservative and surgical management may be considered, the optimal treatment is still uncertain and several studies were published using different techniques (open, laparoscopic or robotic) and approaches (extravesical, transvesical or transvaginal) (2-5). In this context, we aim to report our initial experience repairing VVF with Single-Port (SP) Transvesical (TV) access...
May 3, 2024: International Braz J Urol: Official Journal of the Brazilian Society of Urology
#8
Takenori Isozaki, Mitsuru Matsuki, Akane Yamamoto, Suzuyo Takahashi, Harushi Mori
Struma ovarii is a monodermal teratoma characterized by the presence of >50% thyroid tissue. It is mostly benign; therefore, preoperative diagnosis is important. It usually manifests as a multilocular cystic mass but rarely as a predominantly solid mass. On magnetic resonance imaging (MRI), solid-appearing struma ovarii showed early signal intensity enhancement on dynamic gadolinium-enhanced T1-weighted images, which histopathologically indicates the presence of thyroid tissue with abundant blood vessels...
April 2024: Curēus
#9
Rita Rathore, Sana Ahuja, Nuneno Nakhro, Pallavi Punhani, Sufian Zaheer
Ovarian mature cystic teratomas comprise tissue derived from all three germ layers and constitute 10-20% of all ovarian neoplasms. Malignant transformation of mature cystic teratomas (MCT) is very rare with an incidence of 0.17-2%. The most frequently reported malignancies include squamous cell carcinoma and adenocarcinoma. Herein, we describe a case of a 56-year-old female who presented with abdominal pain and underwent total abdominal hysterectomy with bilateral oophorectomy and omentectomy for a ruptured dermoid cyst...
June 2024: Indian Journal of Surgical Oncology
#10
Ziniu Zhang, Jingxue Yuan, Jingjing Zhao, Yue Song, Jinxia Ni
Premature ovarian insufficiency (POI) is a condition characterized by menstrual disturbance, subfertility, and estrogen deficiency symptoms. Women with POI have a small chance of natural conception, which may be even smaller when complicated with unilateral ovarian due to reduction of the ovarian follicular reserve. In China, acupuncture has been widely used to treat POI and POI-induced infertility, and studies have shown that acupuncture is helpful for improving ovarian function. Thread-embedding therapy is a method of acupuncture treatment development and extension, which can make the acupuncture effect last...
2024: Frontiers in Medicine
#11
JOURNAL ARTICLE
Fhelício Sampaio Viana, Juliana Andrade Pereira, Thaísa Soares Crespo, Lílian Betânia Reis Amaro, Eliezer Francisco Rocha, Alice Crespo Fereira, Deborah de Farias Lelis, Thaís de Oliveira Faria Baldo, Marcelo Perim Baldo, Sérgio Henrique Sousa Santos, João Marcus Oliveira Andrade
Menopause causes important bodily and metabolic changes, which favor the increased occurrence of cardiovascular diseases, obesity, diabetes, and osteoporosis. Resveratrol exerts proven effects on body metabolism, improving glucose and lipid homeostasis and reducing inflammation and oxidative stress in various organs and tissues. Accordingly, this study evaluates the effects of resveratrol supplementation on the expression of markers associated with thermogenesis in brown adipose tissue, and on the body, metabolic and hormonal parameters of female mice submitted to bilateral oophorectomy...
May 10, 2024: Molecular and Cellular Endocrinology
#12
JOURNAL ARTICLE
Adam Kiljańczyk, Milena Matuszczak, Wojciech Marciniak, Róża Derkacz, Klaudia Stempa, Piotr Baszuk, Marta Bryśkiewicz, Krzysztof Lubiński, Cezary Cybulski, Tadeusz Dębniak, Jacek Gronwald, Tomasz Huzarski, Marcin R Lener, Anna Jakubowska, Marek Szwiec, Małgorzata Stawicka-Niełacna, Dariusz Godlewski, Artur Prusaczyk, Andrzej Jasiewicz, Tomasz Kluz, Joanna Tomiczek-Szwiec, Ewa Kilar-Kobierzycka, Monika Siołek, Rafał Wiśniowski, Renata Posmyk, Joanna Jarkiewicz-Tretyn, Ping Sun, Rodney J Scott, Steven A Narod, Jan Lubiński
BRCA1 mutations substantially elevate the risks of breast and ovarian cancer. Various modifiers, including environmental factors, can influence cancer risk. Lead, a known carcinogen, has been associated with various cancers, but its impact on BRCA1 carriers remains unexplored. A cohort of 989 BRCA1 mutation carriers underwent genetic testing at the Pomeranian Medical University, Poland. Blood lead levels were measured using inductively coupled plasma mass spectrometry. Each subject was assigned to a category based on their tertile of blood lead...
April 30, 2024: Nutrients
#13
JOURNAL ARTICLE
M E Madeleine van der Perk, Linda Broer, Yutaka Yasui, Joop S E Laven, Leslie L Robison, Wim J E Tissing, Birgitta Versluys, Dorine Bresters, Gertjan J L Kaspers, Cornelis B Lambalk, Annelies Overbeek, Jacqueline J Loonen, Catharina C M Beerendonk, Julianne Byrne, Claire Berger, Eva Clemens, Eline van Dulmen-den Broeder, Uta Dirksen, Helena J van der Pal, Andrica C H de Vries, Jeanette Falck Winther, Andreas Ranft, Sophie D Fosså, Desiree Grabow, Monica Muraca, Melanie Kaiser, Tomáš Kepák, Jarmila Kruseova, Dalit Modan-Moses, Claudia Spix, Oliver Zolk, Peter Kaatsch, Leontien C M Kremer, Russell J Brooke, Fan Wang, Jessica L Baedke, André G Uitterlinden, Annelies M E Bos, Flora E van Leeuwen, Kirsten K Ness, Melissa M Hudson, Anne-Lotte L F van der Kooi, Marry M van den Heuvel-Eibrink
OBJECTIVE: We aimed to discover new variants associated with low ovarian reserve after gonadotoxic treatment among adult female childhood cancer survivors using a genome-wide association study approach. DESIGN: Genome-wide association study. SUBJECTS: A discovery cohort of adult female childhood cancer survivors, from the pan-European PanCareLIFE cohort (n=743; median age: 25.8 years), excluding those who received bilateral ovarian irradiation, bilateral oophorectomy, central nerve system or total body irradiation, or stem cell transplantation...
May 8, 2024: Fertility and Sterility
#14
JOURNAL ARTICLE
Nidha Gaffoor, Archana Shetty, V Vidhya, P V Nikhil, Vijaya Mysorekar
Ectopic adrenal rests refer to the presence of adrenal tissue outside its normal anatomical location and are usually discovered incidentally on microscopic examination. Literature suggests its occurrence in diverse extrarenal sites, like the genitourinary system and pelvis. Our case describes the rare occurrence of ectopic adrenal rests in the walls of bilateral fallopian tubes of a 43-year-old female patient who presented with a complaint of heavy menstrual bleeding. A total hysterectomy with bilateral salpingo-oophorectomy was performed...
May 10, 2024: Indian Journal of Pathology & Microbiology
#15
Souvik Sarkar, Sandeep Reddy Ramala
This case report explores the complex diagnostic dilemma between the Chilaiditi sign and the pneumoperitoneum. The patient presented with chronic complaints of vague abdominal pain, abdominal distension, and breathlessness. A chest X-ray indicated an elevated right hemidiaphragm with transverse colon interposition, leading to the diagnosis of Chilaiditi's sign. Subsequent imaging, including abdominal ultrasound and contrast-enhanced computed tomography, revealed a large non-enhancing multilobulated multicystic mass adherent to the anterior wall of the uterus, raising suspicions of malignancy...
April 2024: Curēus
#16
JOURNAL ARTICLE
Jiayuan Zhao, Dan Wang, Ruojiao Wang, Yonglan He, Congwei Jia, Lingya Pan, Shuiqing Ma, Ming Wu, Weidi Wang, Xinghan Cheng, Junjun Yang, Yang Xiang
OBJECTIVE: To describe the characteristics of children and adolescents with borderline ovarian tumors (BOTs) and evaluate the efficacy and safety of fertility-sparing surgery (FSS) in these patients. METHODS: Patients with BOTs younger than 20 years who underwent FSS were included in this study. RESULTS: A total of 34 patients were included, with a median patient age of 17 (range, 3-19) years; 97.1% (33/34) of cases occurred after menarche...
May 8, 2024: Journal of Ovarian Research
#17
JOURNAL ARTICLE
Billy Lin, Alexis LeVee, Louie Cao, Reva Basho, Balaji Tamarappoo, Janet Wei, Chrisandra Shufelt
PURPOSE: Breast cancer patients with mutations in human tumor suppressor genes BRCA1 and BRCA2 are at higher risk of cardiovascular disease (CVD) than the general population, as they are frequently exposed to cardiotoxic chemotherapy, anti-estrogen therapy, radiation, and/or oophorectomy for cancer-related treatment and prophylaxis. Animal and cell culture models suggest that BRCA mutations may play an independent role in heart failure. We sought to evaluate cardiac structure and function in female BRCA1 and BRCA2 mutation carriers with breast cancer compared to BRCA wildtype women with breast cancer...
May 8, 2024: Breast Cancer Research and Treatment
#18
JOURNAL ARTICLE
Associations between Hysterectomy and Metabolic Syndrome: The Multi-Ethnic Study of Atherosclerosis.
Eric K Broni, Justin B Echouffo Tcheugui, Anna Palatnik, Ernest M Graham, Ruth-Alma Turkson-Ocran, Yvonne Commodore-Mendah, Chiadi E Ndumele, Erin D Michos
BACKGROUND: Metabolic syndrome is linked to an increased risk of incident cardiovascular disease (CVD) and all-cause mortality. Notable associations exist between hysterectomy with bilateral salpingo-oophorectomy and metabolic syndrome. However, there is emerging evidence that even with ovarian conservation, hysterectomy may be independently associated with long-term CVD risk. OBJECTIVE: To examine the associations between hysterectomy with ovarian preservation and metabolic syndrome risk in a multi-ethnic cohort...
May 2, 2024: American Journal of Obstetrics and Gynecology
#19
JOURNAL ARTICLE
Yossi Geron, Anat From, Yoav Peled, Gil Zeevi, Ran Matot, Sapir Nachshon, Haim Krissi
Objective: Uterine-sparing surgery for pelvic organ prolapse (POP) repair has shown good results, but the potential negative implications of leaving the uterus in place are yet to be fully defined. We aimed to assess the risk of unanticipated abnormal gynecological pathology at the time of reconstructive pelvic surgery. Methods: A retrospective consecutive case series including women who underwent vaginal hysterectomy for POP repair at a tertiary medical center in 2006-2020. All patients were offered a free Pap smear test at the age of 65 years as part of a national screening program...
May 3, 2024: Journal of Women's Health
#20
JOURNAL ARTICLE
Lucy Zhao, Lorrie Lynch, Lua Eiriksson
BACKGROUND: Risk-reducing gynecological surgery (RRGS) is a prophylactic procedure that may be offered to BRCA1, BRCA2, and Lynch syndrome (LS) mutation carriers to reduce the risk of developing gynecological cancer. This study was conducted to better understand patients' information needs and evaluate how patients weigh different sources of information in their decision-making process surrounding RRGS. METHODS: This study used a qualitative approach to understanding women's perspectives towards RRGS...
May 2, 2024: Hereditary Cancer in Clinical Practice
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