Jiaqi Yan, Rajendra Bhadane, Meixin Ran, Xiaodong Ma, Yuanqiang Li, Dongdong Zheng, Outi M H Salo-Ahen, Hongbo Zhang
The metal-nucleic acid nanocomposites, first termed metal-nucleic acid frameworks (MNFs) in this work, show extraordinary potential as functional nanomaterials. However, thus far, realized MNFs face limitations including harsh synthesis conditions, instability, and non-targeting. Herein, we discover that longer oligonucleotides can enhance the synthesis efficiency and stability of MNFs by increasing oligonucleotide folding and entanglement probabilities during the reaction. Besides, longer oligonucleotides provide upgraded metal ions binding conditions, facilitating MNFs to load macromolecular protein drugs at room temperature...
May 1, 2024: Nature Communications