Michael N Saunders, Laila M Rad, Laura A Williams, Jeffrey J Landers, Russell R Urie, Sarah E Hocevar, Miguel Quiros, Ming-Yi Chiang, Amogh R Angadi, Katarzyna W Janczak, Elizabeth J Bealer, Kelly Crumley, Olivia E Benson, Kate V Griffin, Brian C Ross, Charles A Parkos, Asma Nusrat, Stephen D Miller, Joseph R Podojil, Jessica J O'Konek, Lonnie D Shea
Food allergy is a prevalent and potentially deadly disease caused by inadvertent sensitization to benign food antigens. Pathogenic Th2 cells are a major driver for disease, and allergen-specific immunotherapies (AIT) aim to increase the allergen threshold required to elicit severe allergic symptoms. However, the majority of AIT approaches require lengthy treatments and convey transient disease suppression, likely due to insufficient targeting of pathogenic Th2 responses. Here, we investigate the ability of allergen-encapsulating nanoparticles to directly suppress pathogenic Th2 responses and reactivity in a mouse model of food allergy...
May 1, 2024: Advanced Healthcare Materials