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JOURNAL ARTICLE
Charbel Gharios, Mandy M T van Leent, Helena L Chang, Shady Abohashem, David O'Connor, Michael T Osborne, Cheuk Y Tang, Audrey E Kaufman, Philip M Robson, Sarayu Ramachandran, Claudia Calcagno, Venkatesh Mani, Maria Giovanna Trivieri, Antonia V Seligowski, Sharon Dekel, Willem J M Mulder, James W Murrough, Lisa M Shin, Ahmed Tawakol, Zahi A Fayad
BACKGROUND AND AIMS: Chronic stress associates with cardiovascular disease, but mechanisms remain incompletely defined. Advanced imaging was used to identify stress-related neural imaging phenotypes associated with atherosclerosis. METHODS: Twenty-seven individuals with post-traumatic stress disorder (PTSD), 45 trauma-exposed controls without PTSD, and 22 healthy controls underwent 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI)...
May 16, 2024: European Heart Journal
#22
JOURNAL ARTICLE
Limei Han, Jie Yang, Chao Yuan, Wei Zhang, Yantao Huang, Lingli Zeng, Jianquan Zhong
OBJECTIVES: To explore the effectiveness of diffusion quantitative parameters derived from advanced diffusion models in detecting brain microstructural changes in patients with chronic kidney disease (CKD). METHODS: The study comprised 44 CKD patients (eGFR<59 mL/min/1.73 m2 ) and 35 age-and sex-matched healthy controls. All patients underwent diffusion spectrum imaging (DSI) and conventional magnetic resonance imaging. Reconstructed to obtain diffusion MRI models, including diffusion tensor imaging (DTI), neurite orientation dispersion and density imaging (NODDI) and Mean Apparent Propagator (MAP)-MRI, were processed to obtain multi-parameter maps...
2024: Frontiers in Neurology
#23
JOURNAL ARTICLE
Siddharth Srivastava, Fanghan Yang, Anna K Prohl, Peter E Davis, Jamie K Capal, Rajna Filip-Dhima, E Martina Bebin, Darcy A Krueger, Hope Northrup, Joyce Y Wu, Simon K Warfield, Mustafa Sahin, Bo Zhang
Background: Abnormalities in white matter development may influence development of autism spectrum disorder in tuberous sclerosis complex (TSC). Our goals for this study were as follows: (1) use data from a longitudinal neuroimaging study of tuberous sclerosis complex (TACERN) to develop optimized linear mixed effects models for analyzing longitudinal, repeated diffusion tensor imaging metrics (fractional anisotropy, mean diffusivity) pertaining to select white matter tracts, in relation to positive Autism Diagnostic Observation Schedule-Second Edition classification at 36 months, and (2) perform an exploratory analysis using optimized models applied to all white matter tracts from these data...
May 15, 2024: Journal of Child Neurology
#24
JOURNAL ARTICLE
Pavel Filip, Josef Mana, Andrej Lasica, Jiří Keller, Dušan Urgošík, Jaromír May, Karsten Mueller, Robert Jech, Ondrej Bezdicek, Filip Růžička
BACKGROUND AND OBJECTIVES: The intricate relationship between deep brain stimulation (DBS) in Parkinson's disease (PD) and cognitive impairment has lately garnered substantial attention. The presented study evaluated pre-DBS structural and microstructural cerebral patterns as possible predictors of future cognitive decline in PD DBS patients. METHODS: Pre-DBS MRI data in 72 PD patients were combined with neuropsychological examinations and follow-up for an average of 2...
May 8, 2024: NeuroImage: Clinical
#25
JOURNAL ARTICLE
Kening Jiang, Marilyn S Albert, Josef Coresh, David J Couper, Rebecca F Gottesman, Kathleen M Hayden, Clifford R Jack, David S Knopman, Thomas H Mosley, James S Pankow, James R Pike, Nicholas S Reed, Victoria A Sanchez, A Richey Sharrett, Frank R Lin, Jennifer A Deal
PURPOSE: Population-based evidence in the interrelationships among hearing, brain structure, and cognition is limited. This study aims to investigate the cross-sectional associations of peripheral hearing, brain imaging measures, and cognitive function with speech-in-noise performance among older adults. METHOD: We studied 602 participants in the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) brain magnetic resonance imaging (MRI) ancillary study, including 427 ACHIEVE baseline (2018-2020) participants with hearing loss and 175 Atherosclerosis Risk in Communities Neurocognitive Study Visit 6/7 (2016-2017/2018-2019) participants with normal hearing...
May 15, 2024: American Journal of Audiology
#26
JOURNAL ARTICLE
Ali Abdolizadeh, Edgardo Torres-Carmona, Yasaman Kambari, Aron Amaev, Jianmeng Song, Fumihiko Ueno, Teruki Koizumi, Shinichiro Nakajima, Sri Mahavir Agarwal, Vincenzo De Luca, Philip Gerretsen, Ariel Graff-Guerrero
BACKGROUND AND HYPOTHESIS: The glymphatic system (GS), a brain waste clearance pathway, is disrupted in various neurodegenerative and vascular diseases. As schizophrenia shares clinical characteristics with these conditions, we hypothesized GS disruptions in patients with schizophrenia spectrum disorder (SCZ-SD), reflected in increased brain macromolecule (MM) and decreased diffusion-tensor-image-analysis along the perivascular space (DTI-ALPS) index. STUDY DESIGN: Forty-seven healthy controls (HCs) and 103 patients with SCZ-SD were studied...
May 15, 2024: Schizophrenia Bulletin
#27
JOURNAL ARTICLE
Sabahattin Yuzkan, Ozan Hasimoglu, Serdar Balsak, Samet Mutlu, Mehmet Karagulle, Fadime Kose, Ayca Altinkaya, Bekir Tugcu, Burak Kocak
PURPOSE: To assess whether diffusion tensor imaging (DTI) and generalized q-sampling imaging (GQI) metrics could preoperatively predict the clinical outcome of deep brain stimulation (DBS) in patients with Parkinson's disease (PD). METHODS: In this single-center retrospective study, from September 2021 to March 2023, preoperative DTI and GQI examinations of 44 patients who underwent DBS surgery, were analyzed. To evaluate motor functions, the Unified Parkinson's Disease Rating Scale (UPDRS) during on- and off-medication and Parkinson's Disease Questionnaire-39 (PDQ-39) scales were used before and three months after DBS surgery...
May 15, 2024: Acta Neurochirurgica
#28
JOURNAL ARTICLE
Changjiang Zhao, Can Zhang, Li Zhu, Long Chen, Xiong Xiong, Junlong Pan, Jiangjin Chen, Lei Gao, Chengxin Yu, Haibo Xu
BACKGROUND: Motor impairment is the most prevalent consequence following a stroke. Interhemispheric homotopic connectivity, which varies regionally and hierarchically along the axis of the somatomotor-association cortex, plays a critical role in sustaining normal motor functions. However, the impact of strokes occurring in various locations on homotopic connectivity is not fully understood. This study aimed to explore how motor deficits resulting from acute strokes in different locations influence homotopic connectivity...
2024: Frontiers in Neurology
#29
René Labounek, Monica T Bondy, Amy L Paulson, Sandrine Bédard, Mihael Abramovic, Eva Alonso-Ortiz, Nicole T Atcheson, Laura R Barlow, Robert L Barry, Markus Barth, Marco Battiston, Christian Büchel, Matthew D Budde, Virginie Callot, Anna Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostál, Julien Doyon, Adam V Dvorak, Falk Eippert, Karla R Epperson, Kevin S Epperson, Patrick Freund, Jürgen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia A M Gandini Wheeler-Kingshott, GianCarlo Germani, Guillaume Gilbert, Federico Giove, Francesco Grussu, Akifumi Hagiwara, Pierre-Gilles Henry, Tomáš Horák, Masaaki Hori, James M Joers, Kouhei Kamiya, Haleh Karbasforoushan, Miloš Keřkovský, Ali Khatibi, Joo-Won Kim, Nawal Kinany, Hagen Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlička, Paul Kuntke, Nyoman D Kurniawan, Slawomir Kusmia, Maria Marcella Laganà, Cornelia Laule, Christine S W Law, Tobias Leutritz, Yaou Liu, Sara Llufriu, Sean Mackey, Allan R Martin, Eloy Martinez-Heras, Loan Mattera, Kristin P O'Grady, Nico Papinutto, Daniel Papp, Deborah Pareto, Todd B Parrish, Anna Pichiecchio, Ferran Prados, Àlex Rovira, Marc J Ruitenberg, Rebecca S Samson, Giovanni Savini, Maryam Seif, Alan C Seifert, Alex K Smith, Seth A Smith, Zachary A Smith, Elisabeth Solana, Yuichi Suzuki, George W Tackley, Alexandra Tinnermann, Jan Valošek, Dimitri Van De Ville, Marios C Yiannakas, Kenneth A Weber, Nikolaus Weiskopf, Richard G Wise, Patrik O Wyss, Junqian Xu, Julien Cohen-Adad, Christophe Lenglet, Igor Nestrašil
Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject's sex and age. However, corrections for body size (i.e. height and weight) are mostly lacking in clinical neuroimaging designs. This study investigates the importance of body size parameters in their relationship with spinal cord (SC) and brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population of 267 healthy human adults (age 30...
May 1, 2024: bioRxiv
#30
Christopher A Rock, Y Iris Chen, Ruopeng Wang, Anne L Philip, Boris Keil, Rory B Weiner, Sammy Elmariah, Choukri Mekkaoui, Christopher T Nguyen, David E Sosnovik
Current techniques to image the microstructure of the heart with diffusion tensor MRI (DTI) are highly under-resolved. We present a technique to improve the spatial resolution of cardiac DTI by almost 10-fold and leverage this to measure local gradients in cardiomyocyte alignment or helix angle (HA). We further introduce a phenomapping approach based on voxel-wise hierarchical clustering of these gradients to identify distinct microstructural microenvironments in the heart. Initial development was performed in healthy volunteers (n=8)...
May 5, 2024: medRxiv
#31
JOURNAL ARTICLE
Duen-Pang Kuo, Yung-Chieh Chen, Yi-Tien Li, Sho-Jen Cheng, Kevin Li-Chun Hsieh, Po-Chih Kuo, Chen-Yin Ou, Cheng-Yu Chen
BACKGROUND: This study investigates the potential of diffusion tensor imaging (DTI) in identifying penumbral volume (PV) compared to the standard gadolinium-required perfusion-diffusion mismatch (PDM), utilizing a stack-based ensemble machine learning (ML) approach with enhanced explainability. METHODS: Sixteen male rats were subjected to middle cerebral artery occlusion. The penumbra was identified using PDM at 30 and 90 min after occlusion. We used 11 DTI-derived metrics and 14 distance-based features to train five voxel-wise ML models...
May 15, 2024: European Radiology Experimental
#32
REVIEW
Dennison Carreiro Monteiro, Clarence da Silva Ramos, Luís Eduardo Nogueira Nóbrega Alves, Amaury Cantilino, Everton Botelho Sougey
This systematic review aimed to summarize the most recent data on changes in brain structure and function in premenstrual dysphoric disorder (PMDD) as well as elucidate the possible correlations between these findings and symptom severity. Articles published in PubMed, EMBASE, ScienceDirect, PsycInfo, Web of Science, and Scopus from inception until April 2023 were systematically reviewed according to the PICO framework: population (women with PMDD), intervention (neuroimaging study), control (healthy subjects), and outcome (neuroimaging changes)...
May 9, 2024: Journal of Psychiatric Research
#33
JOURNAL ARTICLE
Mahir Tazwar, Arnold M Evia, Abdur Raquib Ridwan, Sue E Leurgans, David A Bennett, Julie A Schneider, Konstantinos Arfanakis
Limbic predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is common in older adults and is associated with neurodegeneration, cognitive decline and dementia. In this MRI and pathology investigation we tested the hypothesis that LATE-NC is associated with abnormalities in white matter structural integrity and connectivity of a network of brain regions typically harboring TDP-43 inclusions in LATE, referred to here as the "LATE-NC network". Ex-vivo diffusion MRI and detailed neuropathological data were collected on 184 community-based older adults...
April 10, 2024: Neurobiology of Aging
#34
EDITORIAL
Matheus Dorigatti Soldatelli, Birgit B Ertl-Wagner
No abstract text is available yet for this article.
May 2024: Radiology
#35
JOURNAL ARTICLE
Qing Ji, Samuel S McAfee, Matthew Scoggins, Joseph Holtrop, John O Glass, Xiaomeng Yuan, Jia Liang, Yimei Li, Jason Chiang, Brent A Orr, Angela Edwards, Diana Storment, Tara Brinkman, Giles W Robinson, Amar Gajjar, Wilburn E Reddick, Zoltán Patay, Raja B Khan, Asim K Bag
Background Cerebellar mutism syndrome (CMS), a complication following medulloblastoma surgery, has been linked to dentato-thalamo-cortical tract (DTCT) injury; the association of the degree of DTCT injury with severity of CMS-related symptoms has not been investigated. Purpose To investigate the association between severity of CMS-related symptoms and degree and patterns of DTCT injury with use of diffusion tensor imaging (DTI), and if laterality of injury influences neurologic symptoms. Materials and Methods This retrospective case-control study used prospectively collected clinical and DTI data on patients with medulloblastoma enrolled in a clinical trial (between July 2016 and February 2020) and healthy controls (between April and November 2017), matched with the age range of the participants with medulloblastoma...
May 2024: Radiology
#36
JOURNAL ARTICLE
Rico Singer, Ina Oganezova, Wanbin Hu, Li Liu, Yi Ding, Huub J M de Groot, Herman P Spaink, A Alia
Toll-like receptor 2 (TLR2) belongs to the TLR protein family that plays an important role in the immune and inflammation response system. While TLR2 is predominantly expressed in immune cells, its expression has also been detected in the brain, specifically in microglia and astrocytes. Recent studies indicate that genomic deletion of TLR2 can result in impaired neurobehavioural function. It is currently not clear if the genomic deletion of TLR2 leads to any alterations in the microstructural features of the brain...
May 14, 2024: NMR in Biomedicine
#37
COMPARATIVE STUDY
Sung Ho Jang, Sang Seok Yeo, Min Jye Cho, William K Chung
BACKGROUND The thalamocortical tract (TCT) links nerve fibers between the thalamus and cerebral cortex, relaying motor/sensory information. The default mode network (DMN) comprises bilateral, symmetrical, isolated cortical regions of the lateral and medial parietal and temporal brain cortex. The Coma Recovery Scale-Revised (CRS-R) is a standardized neurobehavioral assessment of disorders of consciousness (DOC). In the present study, 31 patients with hypoxic-ischemic brain injury (HI-BI) were compared for changes in the TCT and DMN with consciousness levels assessed using the CRS-R...
May 14, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
#38
JOURNAL ARTICLE
Jovanka Skocic, Logan Richard, Ashley Ferkul, Elizabeth Cox, Julie Tseng, Suzanne Laughlin, Eric Bouffet, Donald James Mabbott
BACKGROUND: The microstructural damage underlying compromise of white matter following treatment for pediatric brain tumors is unclear. We use multimodal imaging employing advanced diffusion tensor imaging (DTI) and magnetization transfer imaging (MTI) MRI methods to examine chronic microstructural damage to white matter in children and adolescents treated for pediatric brain tumor. Notably, MTI may be more sensitive to macromolecular content, including myelin, than DTI. METHODS: Fifty patients treated for brain tumors (18 treated with surgery ± chemotherapy and 32 treated with surgery followed by cranial-spinal radiation; time from diagnosis to scan ~6 years) and 45 matched healthy children completed both MTI and DTI scans...
June 2024: Neuro-oncology Practice
#39
JOURNAL ARTICLE
Ying Liu, Binbin Nie, Bing Wu, Shuai Wang, Qiaozhi Ma, Tao Han, Feng Wang, Han Meng, Hao Xie, Xuetao Mu
BACKGROUND: Bronchopulmonary dysplasia (BPD) affects the microstructure of white matter in preterm infants, but its influence on the changes of the brain structural network has not been elaborated. This study aims to investigate the connectivity characteristics of the brain structural network of BPD by using diffusion tensor imaging. METHODS: Thirty-three infants with BPD and 26 infants without BPD were enrolled in this study. Brain structural networks were constructed utilizing automated anatomic labeling mapping by tracing the fibers between each pair of regions in individual space...
April 20, 2024: Pediatric Neurology
#40
JOURNAL ARTICLE
Dong Ah Lee, Ho-Joon Lee, Kang Min Park
PURPOSE: The objective of this research was to examine changes in the neural networks of both gray and white matter in individuals with obstructive sleep apnea (OSA) in comparison to those without the condition, employing a comprehensive multilayer network analysis. METHODS: Patients meeting the criteria for OSA were recruited through polysomnography, while a control group of healthy individuals matched for age and sex was also assembled. Utilizing T1-weighted imaging, a morphometric similarity network was crafted to represent gray matter, while diffusion tensor imaging provided structural connectivity for constructing a white matter network...
May 11, 2024: Sleep & Breathing
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