Annelie Barrueta Tenhunen, Guillaume Butler-Laporte, Satoshi Yoshiji, Dave R Morrison, Tomoko Nakanishi, Yiheng Chen, Vincenzo Forgetta, Yossi Farjoun, Adriana Marton, Jens Titze, Sandra Nihlén, Robert Frithiof, Miklos Lipcsey, J Brent Richards, Michael Hultström
BACKGROUND: Hypertonic dehydration is associated with muscle wasting and synthesis of organic osmolytes. We recently showed a metabolic shift to amino acid production and urea cycle activation in COVID-19, consistent with the aestivation response. The aim of the present investigation was to validate the metabolic shift and development of long-term physical outcome in the non-COVID cohort of the Biobanque Québécoise de la COVID-19 (BQC19). METHODS: We included 824 patients from BQC19, where of 571 patients had data of dehydration in the form of estimated osmolality (eOSM = 2Na+2K+glucose+urea), and 284 patients had metabolome data and long-term follow-up...
May 13, 2024: Physiological Genomics