Most recent papers with the keyword Weissman antibiotic

#1

JOURNAL ARTICLE

Race and Antibiotic Use for Children Hospitalized with Acute Respiratory Infections.

Jenna H Tan, Caitlin L McGrath, Adam W Brothers, Yasaman Fatemi, Victoria Konold, Daniel Pak, Scott J Weissman, Danielle M Zerr, Matthew P Kronman

We sought to evaluate whether children hospitalized with acute respiratory infections experienced differences in antibiotic use by race and ethnicity. We found that likelihood of broad-spectrum antibiotic receipt differed across racial and ethnic groups. Future work should confirm this finding, evaluate causes, and ensure equitable antibiotic use.

38456844

March 8, 2024: Journal of the Pediatric Infectious Diseases Society

#2

Average Nucleotide Identity based Staphylococcus aureus strain grouping allows identification of strain-specific genes in the pangenome.

Vishnu Raghuram, Robert A Petit, Zach Karol, Rohan Mehta, Daniel B Weissman, Timothy D Read

UNLABELLED: Staphylococcus aureus causes both hospital and community acquired infections in humans worldwide. Due to the high incidence of infection S. aureus is also one of the most sampled and sequenced pathogens today, providing an outstanding resource to understand variation at the bacterial subspecies level. We processed and downsampled 83,383 public S. aureus Illumina whole genome shotgun sequences and 1,263 complete genomes to produce 7,954 representative substrains. Pairwise comparison of core gene Average Nucleotide Identity (ANI) revealed a natural boundary of 99...

38352482

January 31, 2024: bioRxiv

#3

JOURNAL ARTICLE

Associations between Isolation Source, Clonal Composition, and Antibiotic Resistance Genes in Escherichia coli Collected in Washington State, USA.

Mary Jewell, Erica R Fuhrmeister, Marilyn C Roberts, Scott J Weissman, Peter M Rabinowitz, Stephen E Hawes

Antimicrobial resistance (AMR) is a global health problem stemming from the use of antibiotics in humans, animals, and the environment. This study used whole-genome sequencing (WGS) of E. coli to explore patterns of AMR across sectors in Washington State, USA (WA). The WGS data from 1449 E. coli isolates were evaluated for isolation source (humans, animals, food, or the environment) and the presence of antibiotic resistance genes (ARGs). We performed sequence typing using PubMLST and used ResFinder to identify ARGs...

38275332

January 20, 2024: Antibiotics

#4

JOURNAL ARTICLE

Study of heavy metal resistance genes in Escherichia coli isolates from a marine ecosystem with a history of environmental pollution (arsenic, cadmium, copper, and mercury).

Ashley S Tseng, Marilyn C Roberts, Scott J Weissman, Peter M Rabinowitz

We analyzed whole genome sequences of 308 Escherichia coli isolates from a marine ecosystem to determine the prevalence and relationships of heavy metal resistance genes (HMRGs) and antibiotic resistance genes (ARGs), as well as the presence of plasmid sequences. We screened all genomes for presence of 18 functional HMRGs conferring resistance to arsenic, cadmium, copper, or cadmium/mercury. In subset analyses, we examined geographic variations of HMRG carriage patterns in 224 isolates from water sources, and sought genetic linkages between HMRGs and ARGs in 25 genomes of isolates resistant to antibiotics...

37972039

2023: PloS One

#5

JOURNAL ARTICLE

Individualized antibiotic plans as a quality improvement initiative to reduce carbapenem use for hematopoietic cell transplant patients at a freestanding pediatric hospital.

Adam W Brothers, Daniel J Pak, Nicole M Poole, Matthew P Kronman, Brendan Bettinger, Jennifer J Wilkes, Paul A Carpenter, Janet A Englund, Scott J Weissman

BACKGROUND: Providers must balance effective empiric therapy against toxicity risks and collateral damage when selecting antibiotic therapy for patients receiving hematopoietic cell transplant (HCT). Antimicrobial stewardship (AMS) interventions during HCT are often challenging due to concern for undertreating potential infections. METHODS: In an effort to decrease unnecessary carbapenem exposure for patients undergoing HCT at our pediatric center, we implemented individualized antibiotic plans (IAPs) to provide recommendations for pre-engraftment neutropenia prophylaxis, empiric treatment of febrile neutropenia, and empiric treatment for hemodynamic instability...

37647637

August 30, 2023: Clinical Infectious Diseases

#6

JOURNAL ARTICLE

Increase in the community circulation of ciprofloxacin-resistant Escherichia coli despite reduction in antibiotic prescriptions.

Veronika Tchesnokova, Lydia Larson, Irina Basova, Yulia Sledneva, Debarati Choudhury, Thalia Solyanik, Jennifer Heng, Teresa Christina Bonilla, Sophia Pham, Ellen M Schartz, Lawrence T Madziwa, Erika Holden, Scott J Weissman, James D Ralston, Evgeni V Sokurenko

BACKGROUND: Community circulating gut microbiota is the main reservoir for uropathogenic Escherichia coli, including those resistant to antibiotics. Ciprofloxacin had been the primary antibiotic prescribed for urinary tract infections, but its broad use has been discouraged and steadily declined since 2015. How this change in prescriptions affected the community circulation of ciprofloxacin-resistant E. coli is unknown. METHODS: We determined the frequency of isolation and other characteristics of E...

37567971

August 12, 2023: Commun Med (Lond)

#7

Novel, sensitivity-based antibiotic regimen for multidrug-resistant Mycobacterium abscessus infection following cosmetic surgery.

Marlee Hill, Amanda S Weissman, Michael Franzetti, Pamela Allen

No abstract text is available yet for this article.

37361401

June 2023: JAAD Case Reports

#8

JOURNAL ARTICLE

Detecting patterns of accessory genome coevolution in Staphylococcus aureus using data from thousands of genomes.

Rohan S Mehta, Robert A Petit, Timothy D Read, Daniel B Weissman

Bacterial genomes exhibit widespread horizontal gene transfer, resulting in highly variable genome content that complicates the inference of genetic interactions. In this study, we develop a method for detecting coevolving genes from large datasets of bacterial genomes based on pairwise comparisons of closely related individuals, analogous to a pedigree study in eukaryotic populations. We apply our method to pairs of genes from the Staphylococcus aureus accessory genome of over 75,000 annotated gene families using a database of over 40,000 whole genomes...

37296404

June 9, 2023: BMC Bioinformatics

#9

Increase in the Rate of Gut Carriage of Fluoroquinolone-Resistant Escherichia coli despite a Reduction in Antibiotic Prescriptions.

Veronika Tchesnokova, Lydia Larson, Irina Basova, Yulia Sledneva, Debarati Choudhury, Jennifer Heng, Thalia Solyanik, Teresa Bonilla, Sophia Pham, Ellen Schartz, Lawrence Madziwa, Erika Holden, Scott Weissman, James Ralston, Evgeni Sokurenko

Background : Fluoroquinolone use for urinary tract infections has been steadily declining. Gut microbiota is the main reservoir for uropathogenic Escherichia coli but whether the carriage of fluoroquinolone-resistant E. coli has been changing is unknown. Methods . We determined the frequency of isolation and other characteristics of E. coli nonsuceptible to fluoroquinolones (at ³0.5 mg/L of ciprofloxacin) in 515 and 1605 E. coli -positive fecal samples collected in 2015 and 2021, respectively, from non-antibiotic- taking women of age 50+ receiving care in the Seattle area Kaiser Permanente Washington healthcare system...

36712036

January 12, 2023: Research Square

#10

JOURNAL ARTICLE

Fresh Versus Frozen Versus Lyophilized Fecal Microbiota Transplant for Recurrent Clostridium Difficile Infection: A Systematic Review and Network Meta-analysis.

Manesh Kumar Gangwani, Muhammad Aziz, Abeer Aziz, Fnu Priyanka, Simcha Weissman, Khiem Phan, Dushyant Singh Dahiya, Zohaib Ahmed, Amir Humza Sohail, Wade Lee-Smith, Faisal Kamal, Toseef Javaid, Ali Nawras, Benjamin Hart

INTRODUCTION: Clostridium difficile Infection is a significant source of morbidity and mortality, which is on the rise. Fecal Microbiota Transplantation (FMT) is an alternative therapy to antibiotics with a high success rate and low relapse rate. Current data regarding the efficacy of the types of FMT used, namely fresh, frozen, and lyophilized is conflicting. Our review attempts to consolidate this data and highlight the most efficacious treatment currently available. METHODOLOGY: MEDLINE, Embase, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, SciELO, the Korean Citation Index, and Global Index Medicus were systematically searched from inception through May 3, 2022...

36656270

March 1, 2023: Journal of Clinical Gastroenterology

#11

JOURNAL ARTICLE

Epidemiology, Outcomes and Tolerability of Protracted Treatment of Nontuberculous Mycobacterial Infections at a Community Teaching Hospital in the Southeastern United States.

Yuwei Vivian Tsai, Caroline Derrick, Ismaeel Yunusa, Sharon Weissman, Majdi N Al-Hasan, Julie Ann Justo, Paul Brandon Bookstaver

Nontuberculous mycobacterial (NTM) infections present a treatment challenge for clinicians and patients. There are limited data about current susceptibility patterns and treatment outcomes in U.S. adults. This was a 10-year, single-center, retrospective, observational cohort study of adults with a positive NTM culture and clinical suspicion of infection between 1 January 2010 and 30 June 2020. The primary objective was to identify predictors for favorable treatment outcomes. Key secondary objectives were characterization of NTM epidemiology, susceptibility profiles, and safety and tolerability of treatment, including the proportion of subjects with an antimicrobial change and the reasons for the change...

36551377

November 29, 2022: Antibiotics

#12

JOURNAL ARTICLE

Desired Characteristics of a Clinical Decision Support System for Early Sepsis Recognition: Interview Study Among Hospital-Based Clinicians.

Jasmine A Silvestri, Tyler E Kmiec, Nicholas S Bishop, Susan H Regli, Gary E Weissman

BACKGROUND: Sepsis is a major burden for health care systems in the United States, with over 750,000 cases annually and a total cost of approximately US $20 billion. The hallmark of sepsis treatment is early and appropriate initiation of antibiotic therapy. Although sepsis clinical decision support (CDS) systems can provide clinicians with early predictions of suspected sepsis or imminent clinical decline, such systems have not reliably demonstrated improvements in clinical outcomes or care processes...

36269653

October 21, 2022: JMIR Human Factors

#13

JOURNAL ARTICLE

A Quantitative Study of Decision Thresholds for Initiation of Antibiotics in Suspected Sepsis.

Stephanie Parks Taylor, Gary E Weissman, Marc Kowalkowski, Andrew J Admon, Sable Skewes, Yunfei Xia, Shih-Hsuing Chou

BACKGROUND: Clinicians' decision thresholds for initiating antibiotics in patients with suspected sepsis have not been quantified. We aimed to define an average threshold of infection likelihood at which clinicians initiate antibiotics when treating a patient with suspected infection and to evaluate the influence of severity of illness and clinician-related factors on the threshold. DESIGN: This was a prospective survey of 153 clinicians responding to 8 clinical vignettes constructed from real-world data from 3 health care systems in the United States...

36062810

September 5, 2022: Medical Decision Making: An International Journal of the Society for Medical Decision Making

#14

JOURNAL ARTICLE

Risk Factors for Development of Pneumatosis Intestinalis after Pediatric Hematopoietic Stem Cell Transplantation: A Single-Center Case-Control Study.

Polina Frolova Gregory, Jonathan Angus, Adam W Brothers, Ashley N Gray, Kristina Skeen, Ted Gooley, Chris Davis, Helen H R Kim, Scott J Weissman, Hengqi Betty Zheng, Kanwaldeep Mallhi, K Scott Baker

The significance of pneumatosis intestinalis (PI) in pediatric patients following hematopoietic stem cell transplantation (HSCT) is poorly understood. A knowledge gap remains with respect to the etiology, risk factors, and evidence-based treatment of these patients. As a result, management is frequently based on each center's clinical practice, without standardization across treatment centers. In this single-center trial, we aimed to validate both previously proposed and additional risk factors for the development of PI and to examine our management and outcomes for these patients...

36038104

November 2022: Transplantation and cellular therapy

#15

JOURNAL ARTICLE

Outpatient Antibiotic Resistance Patterns of Escherichia coli Urinary Isolates Differ by Specialty Type.

Lauren Frisbie, Scott J Weissman, Hema Kapoor, Marisa D'Angeli, Ann Salm, Jeff Radcliff, Peter Rabinowitz

Antibiotic-resistant E. coli infections represent a major cause of morbidity and mortality and pose a challenge to antibiotic stewardship. We analyzed a large outpatient data set of E. coli urinary isolates to determine whether resistance patterns vary between types of outpatient practices. Using deidentified data from a clinical reference laboratory over 5 years and logistic regression, we examined the association of antibiotic resistance with outpatient practice type, controlling for testing year, patient sex, and patient age...

35727039

August 31, 2022: Microbiology Spectrum

#16

JOURNAL ARTICLE

Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a Retrospective Study.

Tanya Babich, Pontus Naucler, John Karlsson Valik, Christian G Giske, Natividad Benito, Ruben Cardona, Alba Rivera, Celine Pulcini, Manal Abdel Fattah, Justine Haquin, Alasdair Macgowan, Sally Grier, Bibiana Chazan, Anna Yanovskay, Ronen Ben Ami, Michal Landes, Lior Nesher, Adi Zaidman-Shimshovitz, Kate McCarthy, David L Paterson, Evelina Tacconelli, Michael Buhl, Susanna Mauer, Jesús Rodríguez-Baño, Marina de Cueto, Antonio Oliver, Enrique Ruiz de Gopegui, Angela Cano, Isabel Machuca, Monica Gozalo-Marguello, Luis Martinez-Martinez, Eva M Gonzalez-Barbera, Iris Gomez Alfaro, Miguel Salavert, Bojana Beovic, Andreja Saje, Manica Mueller-Premru, Leonardo Pagani, Virginie Vitrat, Diamantis Kofteridis, Maria Zacharioudaki, Sofia Maraki, Yulia Weissman, Mical Paul, Yaakov Dickstein, Leonard Leibovici, Dafna Yahav

INTRODUCTION: There is no consensus regarding optimal duration of antibiotic therapy for Pseudomonas aeruginosa bacteremia. We aimed to evaluate the impact of short antibiotic course. METHODS: We present a retrospective multicenter study including patients with P. aeruginosa bacteremia during 2009-2015. We evaluated outcomes of patients treated with short (6-10 days) versus long (11-15 days) antibiotic courses. The primary outcome was a composite of 30-day mortality or bacteremia recurrence and/or persistence...

35612693

August 2022: Infectious Diseases and Therapy

#17

JOURNAL ARTICLE

Temporal Association between Influenza Vaccination Coverage and Ambulatory Antibiotic Use in Children.

Mariam Younas, Julie Royer, Hana R Winders, Sharon B Weissman, P Brandon Bookstaver, Julie Ann Justo, Katie S Waites, Linda Bell, Majdi N Al-Hasan

In this population-based retrospective cohort study, increased influenza vaccination coverage was temporally associated with a reduction in ambulatory antibiotic use in children. After adjustment for yearly vaccine effectiveness, antibiotic prescription rate declined by 3/1000 person-months for each 1% increase in influenza vaccination coverage between 2012 and 2017 in South Carolina (P < 0.001).

35363650

July 1, 2022: Pediatric Infectious Disease Journal

#18

JOURNAL ARTICLE

Surveillance for Antibiotic-Resistant E. coli in the Salish Sea Ecosystem.

Alexandria Vingino, Marilyn C Roberts, Michelle Wainstein, James West, Stephanie A Norman, Dyanna Lambourn, Jeffery Lahti, Ryan Ruiz, Marisa D'Angeli, Scott J Weissman, Peter Rabinowitz

E. coli was isolated from the Salish Sea (Puget Sound) ecosystem, including samples of marine and fresh water, and wildlife dependent on this environment. E. coli isolates were assessed for phenotypic and genotypic resistance to antibiotics. A total of 305 E. coli isolates was characterized from samples collected from: marine water obtained in four quadrants of the Salish Sea; select locations near beaches; fresh water from streams near marine beaches; and fecal samples from harbor porpoises ( Phocoena phocoena ), harbor seals ( Phoca vitulina ), river otters ( Lontra canadensis ), and English sole ( Parophrys vetulus )...

34680782

October 2, 2021: Antibiotics

#19

JOURNAL ARTICLE

Change in Antimicrobial Use during COVID-19 Pandemic in South Carolina Hospitals: A Multicenter Observational Cohort Study.

Hana R Winders, Pamela Bailey, Joseph Kohn, Carmen M Faulkner-Fennell, Sara Utley, Evan Lantz, Lloyd Sarbacker, Julie Ann Justo, P Brandon Bookstaver, Sharon Weissman, Hannah Ruegner, Majdi N Al-Hasan

This retrospective cohort study examined the impact of the pandemic on antimicrobial use (AU) in South Carolina hospitals. AU in days of therapy (DOT) per 1000 days-present was evaluated in 17 hospitals in South Carolina. Matched-pairs mean difference was used to compare AU during the pandemic (March-June 2020) to that during the same months in 2019 in hospitals that did and did not admit patients with COVID-19. There was a 6.6% increase in overall AU in the 7 hospitals admitting patients with COVID-19 (from 530...

34655733

October 13, 2021: International Journal of Antimicrobial Agents

#20

REVIEW

Towards the sustainable discovery and development of new antibiotics.

Marcus Miethke, Marco Pieroni, Tilmann Weber, Mark Brönstrup, Peter Hammann, Ludovic Halby, Paola B Arimondo, Philippe Glaser, Bertrand Aigle, Helge B Bode, Rui Moreira, Yanyan Li, Andriy Luzhetskyy, Marnix H Medema, Jean-Luc Pernodet, Marc Stadler, José Rubén Tormo, Olga Genilloud, Andrew W Truman, Kira J Weissman, Eriko Takano, Stefano Sabatini, Evi Stegmann, Heike Brötz-Oesterhelt, Wolfgang Wohlleben, Myriam Seemann, Martin Empting, Anna K H Hirsch, Brigitta Loretz, Claus-Michael Lehr, Alexander Titz, Jennifer Herrmann, Timo Jaeger, Silke Alt, Thomas Hesterkamp, Mathias Winterhalter, Andrea Schiefer, Kenneth Pfarr, Achim Hoerauf, Heather Graz, Michael Graz, Mika Lindvall, Savithri Ramurthy, Anders Karlén, Maarten van Dongen, Hrvoje Petkovic, Andreas Keller, Frédéric Peyrane, Stefano Donadio, Laurent Fraisse, Laura J V Piddock, Ian H Gilbert, Heinz E Moser, Rolf Müller

An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics...

34426795

August 19, 2021: Nature Reviews. Chemistry

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